Sugar transporters in coral symbiosis and origin of parasitism. We aim to identify how symbiotic algae feed sugar to their coral hosts. Corals need this algal sugar to exist, but no one knows how it is transferred, so understanding this crucial mechanism is hugely significant. The first benefit of this research will be a fundamental understanding about how two organisms (algae and coral) cooperate to build habitats like the Great Barrier Reef. We also aim to explore whether coral/algal coopera ....Sugar transporters in coral symbiosis and origin of parasitism. We aim to identify how symbiotic algae feed sugar to their coral hosts. Corals need this algal sugar to exist, but no one knows how it is transferred, so understanding this crucial mechanism is hugely significant. The first benefit of this research will be a fundamental understanding about how two organisms (algae and coral) cooperate to build habitats like the Great Barrier Reef. We also aim to explore whether coral/algal cooperation paved the way for the origin of parasitism. The second key outcome will be to identify the precise molecular mechanism that allowed parasitism to arise. This will benefit us through understanding the origins of important diseases such as human malaria and related infections of livestock and wildlife.
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Engineering a chromatin looping factor for artificial gene regulation. This project aims to define mechanisms of chromatin looping and gene activation by a widely expressed mammalian protein. The project will establish if the functions of this protein are modulated by the binding of small molecules, whether it can act in conjunction with closely related proteins, and if post-translational modifications regulate looping and gene activation. Using protein engineering the project will develop synth ....Engineering a chromatin looping factor for artificial gene regulation. This project aims to define mechanisms of chromatin looping and gene activation by a widely expressed mammalian protein. The project will establish if the functions of this protein are modulated by the binding of small molecules, whether it can act in conjunction with closely related proteins, and if post-translational modifications regulate looping and gene activation. Using protein engineering the project will develop synthetic looping factors that can switch on a wide array of target genes. The project aims to answer fundamental questions about how proteins can establish and maintain physical loops in DNA to modulate gene expression. The project will also develop research tools that might ultimately correct diseases caused by the faulty expression of genes.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE190100730
Funder
Australian Research Council
Funding Amount
$414,216.00
Summary
Designing for early engagement and wellbeing in palliative care. This project aims to generate design guidelines to assist architects in creating better palliative care environments to mitigate the stress associated with end-of-life events for patients, their families and healthcare teams. Facing death, either one’s own or that of a family member, is one of life’s most difficult experiences. Targeted design interventions can encourage early engagement with palliative care, enhance communication ....Designing for early engagement and wellbeing in palliative care. This project aims to generate design guidelines to assist architects in creating better palliative care environments to mitigate the stress associated with end-of-life events for patients, their families and healthcare teams. Facing death, either one’s own or that of a family member, is one of life’s most difficult experiences. Targeted design interventions can encourage early engagement with palliative care, enhance communication and social support in palliative care environments and support staff to deliver optimal patient care. These factors have all been shown to contribute positively to wellbeing. This project will provide benefits for patients, their families and healthcare teams.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE240100001
Funder
Australian Research Council
Funding Amount
$432,251.00
Summary
Investigating public support for climate aid in Australia and abroad. This project aims to investigate public attitudes towards policies that provide aid to those affected by climate change, including resettlement for those displaced. It aims to do so using a series of innovative approaches, including large-scale international surveys and novel experiments. Expected outcomes of this project include new knowledge about the degree of public support for these climate policies and the psychological ....Investigating public support for climate aid in Australia and abroad. This project aims to investigate public attitudes towards policies that provide aid to those affected by climate change, including resettlement for those displaced. It aims to do so using a series of innovative approaches, including large-scale international surveys and novel experiments. Expected outcomes of this project include new knowledge about the degree of public support for these climate policies and the psychological predictors of public acceptability of climate aid and climate migration. This should provide significant benefits, such as by building Australia’s capacity for effective social and policy responses to climate change, and helping Australia plan for the repercussions of environmental change on social cohesion. Read moreRead less
An Intellectual History of Modern Australian Planning 1900-2000. Urban planning is forward-looking but is constantly leveraging knowledge from the past. This original project will investigate the key ideas which have shaped modern planning thought in Australia, concentrating on the 20th century. It will focus on leading practitioners, advocates, public intellectuals, and community critics in an ideas-centred intellectual history that fills a major knowledge gap. The critical transition away from ....An Intellectual History of Modern Australian Planning 1900-2000. Urban planning is forward-looking but is constantly leveraging knowledge from the past. This original project will investigate the key ideas which have shaped modern planning thought in Australia, concentrating on the 20th century. It will focus on leading practitioners, advocates, public intellectuals, and community critics in an ideas-centred intellectual history that fills a major knowledge gap. The critical transition away from post-consensus planning in the last 3 decades of the 20th century will be an important focus and linked to a national oral history exercise before the opportunity is lost forever. Development of an open access biographical website sharing data will bedrock the project.Read moreRead less
Locating Giurgola: From Philadelphia School to Global Practice. This project aims to conduct the first major systematic assessment of the architectural career of Romaldo Giurgola (1920-2016), the principal architect of Australian Parliament House. It will review all known archives relating to his life and works, including significant collections in North America and Australia, and it will survey the full range of his architectural projects. The project expects to result in a new and complete ass ....Locating Giurgola: From Philadelphia School to Global Practice. This project aims to conduct the first major systematic assessment of the architectural career of Romaldo Giurgola (1920-2016), the principal architect of Australian Parliament House. It will review all known archives relating to his life and works, including significant collections in North America and Australia, and it will survey the full range of his architectural projects. The project expects to result in a new and complete assessment of Giurgola's architecture, figuring important Australian buildings into an international landscape of professional practice. The primary outcome of this project will be a large critical catalogue, presenting the full extent of his career for the first time and locating APH in that career in new terms.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE200100529
Funder
Australian Research Council
Funding Amount
$417,128.00
Summary
Scenario testing for sustainable Australian agricultural landscapes to 2050. This project aims to develop and apply the first systems-based projective spatial methodology for evaluating and communicating Australian agricultural landscape scenarios to 2050. Its conceptual framework combines the synergistic approaches of geodesign, scenario testing and projective design to generate empirically-informed scenarios to spatialise agriculture's national environmental, social, economic, demographic and ....Scenario testing for sustainable Australian agricultural landscapes to 2050. This project aims to develop and apply the first systems-based projective spatial methodology for evaluating and communicating Australian agricultural landscape scenarios to 2050. Its conceptual framework combines the synergistic approaches of geodesign, scenario testing and projective design to generate empirically-informed scenarios to spatialise agriculture's national environmental, social, economic, demographic and competing land-use challenges. Benefits and outcomes will support robust decision-making processes to reduce risk and contribute to more intergenerationally sustainable Australian agricultural practices, industries, communities and landscapes.Read moreRead less
Architectural Work Cultures: professional identity, education and wellbeing. This project aims to examine the work and study cultures of architecture in Australia, in relation to professional identity, and in terms of impact on wellbeing, with a whole-of-career scope spanning education to retirement. It will generate the first comprehensive account of work-related wellbeing problems for both architectural practitioners and students, via qualitative and quantitative methods and a vigorous engagem ....Architectural Work Cultures: professional identity, education and wellbeing. This project aims to examine the work and study cultures of architecture in Australia, in relation to professional identity, and in terms of impact on wellbeing, with a whole-of-career scope spanning education to retirement. It will generate the first comprehensive account of work-related wellbeing problems for both architectural practitioners and students, via qualitative and quantitative methods and a vigorous engagement with the profession. Expected outcomes include two toolkits to assist the profession to support cultural change across educational, workplace and institutional settings. This should provide significant benefits for the wellbeing of architects at all career stages, and also support the long-term viability of the sector.Read moreRead less
Understanding glycopolymer interactions with the extracellular matrix. This project aims to advance knowledge of the biochemical and biophysical structure of the endothelial glycocalyx, a dynamic cell surface extracellular matrix rich in proteoglycans and glycosaminoglycans. It will be the first to explore how charged glycopolymers interact with this dynamic interface with the goal to develop a model of the glycocalyx lifecycle. This project is expected to enable the transfer of skills, knowledg ....Understanding glycopolymer interactions with the extracellular matrix. This project aims to advance knowledge of the biochemical and biophysical structure of the endothelial glycocalyx, a dynamic cell surface extracellular matrix rich in proteoglycans and glycosaminoglycans. It will be the first to explore how charged glycopolymers interact with this dynamic interface with the goal to develop a model of the glycocalyx lifecycle. This project is expected to enable the transfer of skills, knowledge and ideas as well as advanced research and industrial training for young scientists. Knowledge derived from this project is expected to enable future innovation in molecules with tailored interactions with the glycocalyx with significant benefits for researchers, manufacturers and end users. Read moreRead less