Improving Ways Of Thinking And Ways Of Doing Aboriginal And Cross-cultural Health In General Practice
Funder
National Health and Medical Research Council
Funding Amount
$948,465.00
Summary
Aboriginal community controlled health services and private general practice need to work together to close the gap. This practice-based cultural respect program and toolkit establishes a care partnership, with Aboriginal cultural mentors, to support strategies to embed cultural respect in general practices on an ongoing basis. Success indicators include a cultural quotient measure, performance of Aboriginal health checks and management of risk factors. The program may also benefit cross-cultura ....Aboriginal community controlled health services and private general practice need to work together to close the gap. This practice-based cultural respect program and toolkit establishes a care partnership, with Aboriginal cultural mentors, to support strategies to embed cultural respect in general practices on an ongoing basis. Success indicators include a cultural quotient measure, performance of Aboriginal health checks and management of risk factors. The program may also benefit cross-cultural health generally.Read moreRead less
A Phase I Study Of Autologous CD19 Specific Chimeric Antigen Receptor T-cells For Therapy Of Relapsed And Refractory B-cell Leukaemia And Lymphoma (The Auto-CAR19 Trial).
Funder
National Health and Medical Research Council
Funding Amount
$584,666.00
Summary
Most people with leukaemia and lymphoma who relapse early after chemotherapy die of their disease. Inserting special genes into immune cells can enable them to kill leukaemia and lymphoma and has led to dramatic cures, but the cost of the viral vectors used to make these cells is prohibitively expensive. We will make leukaemia and lymphoma specific immune cells from patients using an inexpensive non-viral system, then administer the immune cells to patients to assess their safety and efficacy.
Probiotic Prawn Oral Immunotherapy (ProPIT) For Treatment Of Prawn Allergy
Funder
National Health and Medical Research Council
Funding Amount
$1,865,369.00
Summary
A ‘curative’ food allergy treatment is needed to prevent deaths and improve care. We recently showed that probiotic peanut oral immunotherapy (PPOIT) was highly effective for treating peanut allergy. 82% of PPOIT treated children gained tolerance compared to 4% of the placebo group. We will now test the combined probiotic-food OIT approach for treating prawn allergy. If successful, we will have identified the first treatment for prawn allergy and a platform treatment for other food allergies.
Treatment Of Acute Otitis Media (AOM) In Low Risk Aboriginal Children
Funder
National Health and Medical Research Council
Funding Amount
$1,640,326.00
Summary
A randomised clinical trial design will be used to compare two different approaches to the treatment of acute middle ear infections in Aboriginal children living in urban communities: initial observation or immediate antibiotic prescription. The relative acceptability and cost effectiveness of treatment options will be studied. The evidence will allow primary care clinicians to confidently recommend treatment that maximises health benefits and reduces complications such as hearing impairment.
A Phase I Study Of PiggyBac CD19 Specific Chimeric Antigen Receptor T-cells For Therapy Of Persistent And Relapsed B-cell Leukaemia And Lymphoma Post Allogeneic Stem Cell Transplantation (The CARTELL Study).
Funder
National Health and Medical Research Council
Funding Amount
$357,590.00
Summary
Most people with relapsed leukaemia and lymphoma after bone marrow transplant die of their disease. Inserting special genes into immune cells can enable them to kill leukaemia and lymphoma and has led to dramatic cures, but there is little experience in bone marrow transplant patients. We will make leukaemia and lymphoma specific immune cells from normal bone marrow transplant donors, then administer the immune cells to transplant patients to assess their safety and effectiveness.
General relativistic light propagation effects: new insight into cosmic voids, dark matter, dark energy, and Einstein's theory of gravity. This project aims to be the first to develop new methods which will allow accurate study of light propagation effects. These methods remove the “noise” (light propagation effects) from observational data, resulting in unprecedented accuracy of the analyses and new insight into properties of dark energy. At the same time these methods use the “noise” as the ac ....General relativistic light propagation effects: new insight into cosmic voids, dark matter, dark energy, and Einstein's theory of gravity. This project aims to be the first to develop new methods which will allow accurate study of light propagation effects. These methods remove the “noise” (light propagation effects) from observational data, resulting in unprecedented accuracy of the analyses and new insight into properties of dark energy. At the same time these methods use the “noise” as the actual signal to measure properties of the Universe, especially the mass distribution inside cosmic voids (places in the Universe avoided by galaxies), which will solve the problem of dark matter distribution inside cosmic voids. The project aims to use light propagation effects to test Einstein's theory of gravity at cosmological scales.Read moreRead less
Redirecting T-cells For Immunotherapy Of Leukaemia And Lymphoma By The Expression Of A CD19-specific Chimeric Antigen Receptor Using The PiggyBac Transposon Gene Modification System
Funder
National Health and Medical Research Council
Funding Amount
$374,876.00
Summary
Most lymphomas respond to therapy but then relapse. Immune cells can attack and kill virus related lymphomas. However, most lymphomas are NOT virus related. We will create immune cells targeting these virus negative lymphomas by inserting artificial receptors into the immune cells. These receptors attach to the lymphoma and activate the immune cells. The immune cells will home to the lymphoma, kill lymphoma cells and persist in the body for many years, preventing lymphoma relapse.
Discovery Early Career Researcher Award - Grant ID: DE210101738
Funder
Australian Research Council
Funding Amount
$345,000.00
Summary
Discovering the most extreme pulsars with the next generation radio surveys. Finding radio pulsars has always been an extremely rewarding challenge and has led to Nobel Prize winning science. We are now entering a new era of radio astronomy and have new game changers, sensitive, wide-field-of-view imaging telescopes and massive compute resources, to search for extreme pulsars. Such pulsars, including pulsar-blackhole systems and sub-millisecond pulsars, cannot be found with traditional pulsar su ....Discovering the most extreme pulsars with the next generation radio surveys. Finding radio pulsars has always been an extremely rewarding challenge and has led to Nobel Prize winning science. We are now entering a new era of radio astronomy and have new game changers, sensitive, wide-field-of-view imaging telescopes and massive compute resources, to search for extreme pulsars. Such pulsars, including pulsar-blackhole systems and sub-millisecond pulsars, cannot be found with traditional pulsar surveys, but provide us unique laboratories to test gravity theories at ultra-strong gravitational fields and probe the state of matter at supra-nuclear densities. In this project I will leverage the Australian Square Kilometre Array Pathfinder (ASKAP) to discover the most extreme pulsars in deep all-sky continuum surveys.Read moreRead less
Radio follow-up of gravitational wave events. This project aims to use three Australian radio telescopes to search for and monitor radio waves from future gravitational wave events. The detection of gravitational waves and electromagnetic radiation from a neutron star merger was a scientific breakthrough, with important implications for physics and astronomy. The observations from this project will provide key information to reveal what causes some of the most energetic events in the Universe, t ....Radio follow-up of gravitational wave events. This project aims to use three Australian radio telescopes to search for and monitor radio waves from future gravitational wave events. The detection of gravitational waves and electromagnetic radiation from a neutron star merger was a scientific breakthrough, with important implications for physics and astronomy. The observations from this project will provide key information to reveal what causes some of the most energetic events in the Universe, their environment and how they evolve. The outcomes of this project include increased international collaboration with this global effort, and new techniques for automatic data processing and analysis, as well as engaging future students as we build Australian expertise in a new area of research.Read moreRead less
Do black holes exist? This project aims to verify if black holes can actually exist in our Universe. It is still unknown if any of the candidate objects possess the key black hole feature -- a trapped region from which no signal can escape. By focusing on conditions for existence of trapped regions, this project expects to describe their neighborhoods and observable properties. This information is critical for interpretation of the data from the next generation of gravitational wave detectors an ....Do black holes exist? This project aims to verify if black holes can actually exist in our Universe. It is still unknown if any of the candidate objects possess the key black hole feature -- a trapped region from which no signal can escape. By focusing on conditions for existence of trapped regions, this project expects to describe their neighborhoods and observable properties. This information is critical for interpretation of the data from the next generation of gravitational wave detectors and radio telescopes, and for determining the true nature of astrophysical black hole candidates. Further benefits include simplification of calculations of the observable properties of compact objects and resolution of a long-standing black hole information loss paradox.Read moreRead less