This study is aimed at identifying genetic variants that influence susceptibility to migraine. We plan to use DNA samples already collected from families with multiple migraine affected individuals and sequence a region on the X chromosome that has previously been identified as harbouring a migraine susceptibility gene. This project will identify gene(s) that contain variants contributing to migraine.
Development And Application Of A Mendelian Randomization Framework Aimed At Dissecting The Biological Basis Of Ankylosing Spondylitis And Other Complex Diseases
Funder
National Health and Medical Research Council
Funding Amount
$279,666.00
Summary
Our aim is to identify genes and biological molecules that cause a type of autoimmune arthritis called ankylosing spondylitis. Our approach involves finding combinations of genes that are related to biological molecules of interest and then testing to see whether the gene combination is also related to risk of disease. We hope that our strategy will lead to new drug treatments targeting the condition.
Making better decisions about built assets: learning by doing. This research will assist the built environment professions and their clients to make better decisions about new developments through a novel 'learning by doing' approach. Used successfully in other fields such as natural resource management, this idea will capitalise on the large number of asset investments undertaken to benchmark original stakeholder intentions and aspirations against the reality of current performance. Decisions w ....Making better decisions about built assets: learning by doing. This research will assist the built environment professions and their clients to make better decisions about new developments through a novel 'learning by doing' approach. Used successfully in other fields such as natural resource management, this idea will capitalise on the large number of asset investments undertaken to benchmark original stakeholder intentions and aspirations against the reality of current performance. Decisions will be re-evaluated in the context of contemporary economic, social and environmental criteria to enable existing multi-criteria models to deliver more sustainable outcomes that are also feasible and in the national interest, and consequently minimise the industry's current exposure to future climate change.Read moreRead less
Strategic Assessment of Building Adaptive Reuse Opportunities. This research will review a large database of existing buildings, many of which have exceeded their useful life. An innovative model will be developed to enable Australia's building and property industries to identify the most viable opportunities for building adaptive reuse. The model will integrate financial, environmental and social sustainability, enabling community stakeholders to make informed decisions with widespread benefits ....Strategic Assessment of Building Adaptive Reuse Opportunities. This research will review a large database of existing buildings, many of which have exceeded their useful life. An innovative model will be developed to enable Australia's building and property industries to identify the most viable opportunities for building adaptive reuse. The model will integrate financial, environmental and social sustainability, enabling community stakeholders to make informed decisions with widespread benefits. The research is aligned with the national priority area: An Environmentally Sustainable Australia: Transforming Existing Industries. The expertise developed in this project will be regionally and internationally applicable, providing momentum for the growing adaptive design and conservation market.Read moreRead less
Evaluating The Genetic Contribution To Rheumatic Heart Disease Pathogenesis In Australian Aboriginal And Torres Strait Islander Communities
Funder
National Health and Medical Research Council
Funding Amount
$1,782,074.00
Summary
Rheumatic heart disease is highly prevalent in Aboriginal people in Australia and leads to early cardiac disease. Despite decades of research, the underlying genetic mechanisms for why it occurs are not well understood. We are conducting a genetic study to better understand why some people are susceptible to RHD and others are not. The study will involve substantial Aboriginal leadership and consultation and will be a model for the conduct of genetic studies in Aboriginal populations.
Novel Ways Of Utilizing Genome-wide DNA Methylation Data From Peripheral Blood Samples In Genetic Epidemiology
Funder
National Health and Medical Research Council
Funding Amount
$285,186.00
Summary
The aim of this project is to develop statistical methods and paradigms to better leverage the considerable amount of peripheral blood DNA methylation data that has been collected from large scale epidemiological studies. In particular, our focus is on developing and optimizing statistical methods of using DNA methylation profiles to “tag” environmental exposures, so that this information can be better utilized to investigate the genetic and environmental basis of complex traits and diseases.
Understanding the lessons of Australia's Gold Coast through the late 20th century debate on criticality and instrumentality in architecture. This project will investigate the role of architecture in the western city through problems in 20th century architectural theory. It will show how the Gold Coast offers new insights into contemporary architecture and will result in two closely related books: an architectural history of the Gold Coast; and a new account of contemporary architectural theory.
Using Methods In Genetic Epidemiology To Elucidate The Relationship Between Viral Infection And Risk Of Autoimmune Disease
Funder
National Health and Medical Research Council
Funding Amount
$622,446.00
Summary
Autoimmune diseases occur when the body's natural defense mechanisms attack healthy tissues by mistake. It has long been thought that viral infections might play a role in triggering autoimmune disease. Our study aims to find genes that influence the body's response to viral infection and subsequently whether the same genes are involved in autoimmune disease pathology. If the same genes are important in both situations then this will provide evidence that viruses trigger autoimmune disease.
Developing And Applying Statistical Genetics Methods To Identify Genes, Molecular Biomarkers And Environmental Agents That Causally Affect Risk Of Complex Musculoskeletal Diseases
Funder
National Health and Medical Research Council
Funding Amount
$707,370.00
Summary
My aim is to identify genes, biological molecules and environmental factors that causally affect risk of osteoporosis and ankylosing spondylitis (a form of autoimmune arthritis) using novel and existing statistical genetics methodologies. My research will advance understanding of the causes of these diseases, identify new opportunities for their treatment, and provide the scientific community with new statistical methods and software to identify factors that causally influence risk of disease.
Emerging futures: transit-oriented development as a strategy for dealing with urban sprawl and congestion in South East Queensland. This project will examine the phenomenon of urban sprawl in SEQ to understand how sprawl is impacting on architectural and urban environments. Transit-oriented devlopment (TOD)is seen as a global strategy for inhibiting urban sprawl, but the benefits of TOD are not yet measured in Australia. With increased density around railway infrastructure the threat to public s ....Emerging futures: transit-oriented development as a strategy for dealing with urban sprawl and congestion in South East Queensland. This project will examine the phenomenon of urban sprawl in SEQ to understand how sprawl is impacting on architectural and urban environments. Transit-oriented devlopment (TOD)is seen as a global strategy for inhibiting urban sprawl, but the benefits of TOD are not yet measured in Australia. With increased density around railway infrastructure the threat to public safety is raised. This study will examine the wider issues of TOD with respect to four inter-disciplinary areas: architecture and urban design, urban planning, security, counter-terrorism and threat management, transport strategy and insitutional management.Read moreRead less