Evaluating The Genetic Contribution To Rheumatic Heart Disease Pathogenesis In Australian Aboriginal And Torres Strait Islander Communities
Funder
National Health and Medical Research Council
Funding Amount
$1,782,074.00
Summary
Rheumatic heart disease is highly prevalent in Aboriginal people in Australia and leads to early cardiac disease. Despite decades of research, the underlying genetic mechanisms for why it occurs are not well understood. We are conducting a genetic study to better understand why some people are susceptible to RHD and others are not. The study will involve substantial Aboriginal leadership and consultation and will be a model for the conduct of genetic studies in Aboriginal populations.
Psychosocial Aspects Of Genomic Testing For Breast Cancer Risk
Funder
National Health and Medical Research Council
Funding Amount
$108,902.00
Summary
Assessing a woman’s breast cancer risk by profiling polygenic risk represents a new approach in the familial cancer setting. My study is part of a program of research that aims to facilitate translation of polygenic risk information into clinical practice. For this, I will invite 400 women to receive their personal polygenic result and i) assess interest in receiving this result; ii) assess psychological and behavioural outcomes of receiving or not receiving their personal polygenic risk result
Most eye diseases have a genetic contribution, whether rare disorders affecting children such as retinoblastoma or congenital cataracts through to common disorders of older people such as myopia, age-related macular degeneration or glaucoma. We will continue our successful research to find genes that cause these diseases and use this to improve patient care and prevent blindness. We will work out how families can use this genetic information to participate in trials to develop new treatments.
Trans-dimensional and Approximate Bayesian Computation. Many applied scientists in Australia, particularly those in the biological, medical and environmental sciences are now interested in incorporating Bayesian statistical methodologies into their research.
The development of more generic and efficient Bayesian statistical methods will not only benefit applied statisticians but also the more occasional users of statistics in other disciplinary areas. The success of this project will enhance Au ....Trans-dimensional and Approximate Bayesian Computation. Many applied scientists in Australia, particularly those in the biological, medical and environmental sciences are now interested in incorporating Bayesian statistical methodologies into their research.
The development of more generic and efficient Bayesian statistical methods will not only benefit applied statisticians but also the more occasional users of statistics in other disciplinary areas. The success of this project will enhance Australia's reputation as a strong contributor to the development of Bayesian methodologies. Two PhD students will also be provided training in computational Bayesian statistics.Read moreRead less
A gold-coated magnetic nanoparticle biosensor for detecting microRNA. The project aims to develop a biosensor for detecting short sequences of RNA, called microRNA (miRNA) in blood. There are about 100 miRNA sequences that are involved in most biological processes. Changes in the levels of some miRNA sequences can serve as a biomarker for many diseases including cancers. The miRNA will be detected using gold-coated magnetic nanoparticles modified with DNA sequences complementary to the miRNA of ....A gold-coated magnetic nanoparticle biosensor for detecting microRNA. The project aims to develop a biosensor for detecting short sequences of RNA, called microRNA (miRNA) in blood. There are about 100 miRNA sequences that are involved in most biological processes. Changes in the levels of some miRNA sequences can serve as a biomarker for many diseases including cancers. The miRNA will be detected using gold-coated magnetic nanoparticles modified with DNA sequences complementary to the miRNA of interest to capture the miRNA. Application of a magnetic field allows the levels of miRNA to be detected electrochemically. The expected outcome is a commercialisable biosensor for miRNA both as a diagnostic early detection device and a prognostic device for a range of miRNA biomarkers.Read moreRead less
The Role of Torpor in the Life of Arid Zone Mammals. Global warming is predicted to significantly affect our climate. The study will provide critical information about the thermal and energetic capabilities and requirements of native Australian mammals. As little is known about the functional adaptations of arid zone mammals in the wild, these results will be a significant advancement in knowledge about the biology of native Australian species. The data will allow us to predict whether and how p ....The Role of Torpor in the Life of Arid Zone Mammals. Global warming is predicted to significantly affect our climate. The study will provide critical information about the thermal and energetic capabilities and requirements of native Australian mammals. As little is known about the functional adaptations of arid zone mammals in the wild, these results will be a significant advancement in knowledge about the biology of native Australian species. The data will allow us to predict whether and how populations may be affected in the future and provide wildlife managers with an additional tool for making appropriate and sound decisions for the conservation of wildlife. Moreover, the project will enhance the scientific standing of Australia, improve international collaboration, and train students.Read moreRead less
Cool mammals: responding to thermal and energetic challenges in the Australian tropics. A detailed understanding of thermal biology and energy use of mammals is essential for predicting how they will respond to climate change. As little is known about the functional and behavioural traits of Australian tropical mammals, the proposed work investigating the thermal energetics and foraging biology of eleven native species will result in a significant advancement in knowledge. This information will ....Cool mammals: responding to thermal and energetic challenges in the Australian tropics. A detailed understanding of thermal biology and energy use of mammals is essential for predicting how they will respond to climate change. As little is known about the functional and behavioural traits of Australian tropical mammals, the proposed work investigating the thermal energetics and foraging biology of eleven native species will result in a significant advancement in knowledge. This information will provide wildlife managers with an additional tool for making sound science-based decisions for the conservation of wildlife now and in the future. The project will train students, improve international collaboration, and substantially enhance the international scientific standing of Australia.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE170100068
Funder
Australian Research Council
Funding Amount
$390,000.00
Summary
Bioinspired liposome-based smart sensors. This project aims to develop a liposome-based biosensor technology that mimics cell sensory systems. Selective detection of compounds is increasingly important for food, health and environmental monitoring. Biosensor development faces long-standing challenges such as response time, sensitivity, specificity, and multiplexing. On the other hand, cells can sense and discriminate multiple biomolecules in seconds with high sensitivity and specificity. This pr ....Bioinspired liposome-based smart sensors. This project aims to develop a liposome-based biosensor technology that mimics cell sensory systems. Selective detection of compounds is increasingly important for food, health and environmental monitoring. Biosensor development faces long-standing challenges such as response time, sensitivity, specificity, and multiplexing. On the other hand, cells can sense and discriminate multiple biomolecules in seconds with high sensitivity and specificity. This project aims to harness cells’ exquisite biological properties to improve current detection techniques. It will integrate liposome-based sensors with microfluidics to perform analytical tasks ranging from food safety to diagnostics.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0668155
Funder
Australian Research Council
Funding Amount
$350,000.00
Summary
Instrumentation for combined seismic and electromagnetic Earth sounding. The set of geophysical recorders will provide the means to enhance understanding of the structure of the Australian continent in 3-D. The interpretation of multiple images of Earth structure will help to link features in the crust and mantle beneath, and provide controls on the evolution and assembly of the present continent, with a major contribution to possible geotransects as recommended in the 2003 National Strategic Pl ....Instrumentation for combined seismic and electromagnetic Earth sounding. The set of geophysical recorders will provide the means to enhance understanding of the structure of the Australian continent in 3-D. The interpretation of multiple images of Earth structure will help to link features in the crust and mantle beneath, and provide controls on the evolution and assembly of the present continent, with a major contribution to possible geotransects as recommended in the 2003 National Strategic Plan for the Geosciences. Combining seismic and electromagnetic methods will provide both geochemeical and geophysical constaints, e.g., on zones of alteration and shear with the potential for deep mineralisation. Read moreRead less
A one million year record of relative sea-level, climatic and environmental changes - Aeolianites of the southern Australian continental margin. This project will (1) further refine two dating methods that will revolutionize Australia's capacity to date geological and archaeological events; (2) ensure that Australia remains in the forefront in applied geochronology and that a sufficient level of technical expertise remains within the country; (3) examine the sensitivity of coastal environments t ....A one million year record of relative sea-level, climatic and environmental changes - Aeolianites of the southern Australian continental margin. This project will (1) further refine two dating methods that will revolutionize Australia's capacity to date geological and archaeological events; (2) ensure that Australia remains in the forefront in applied geochronology and that a sufficient level of technical expertise remains within the country; (3) examine the sensitivity of coastal environments to rapid climate and sea-level changes; (4) increase public awareness of the scientific basis for the unique nature of Australia's coastal landscapes; and (5) may also assist in the exploration of strategically important minerals. Read moreRead less