Evaluating The Genetic Contribution To Rheumatic Heart Disease Pathogenesis In Australian Aboriginal And Torres Strait Islander Communities
Funder
National Health and Medical Research Council
Funding Amount
$1,782,074.00
Summary
Rheumatic heart disease is highly prevalent in Aboriginal people in Australia and leads to early cardiac disease. Despite decades of research, the underlying genetic mechanisms for why it occurs are not well understood. We are conducting a genetic study to better understand why some people are susceptible to RHD and others are not. The study will involve substantial Aboriginal leadership and consultation and will be a model for the conduct of genetic studies in Aboriginal populations.
Most eye diseases have a genetic contribution, whether rare disorders affecting children such as retinoblastoma or congenital cataracts through to common disorders of older people such as myopia, age-related macular degeneration or glaucoma. We will continue our successful research to find genes that cause these diseases and use this to improve patient care and prevent blindness. We will work out how families can use this genetic information to participate in trials to develop new treatments.
Congestion management in key road networks of a major city through real time data collection, intelligent forecasting and real time routing. The project researches the issues for allowing Australian Road Traffic Authorities to automatically capture road traffic data, forecast traffic flows and smartly route traffic flows to avoid congestion on road networks. This will lead to several benefits, such as (a) reducing traffic congestion, shorten travel time and lower pollution, (b) better utilizati ....Congestion management in key road networks of a major city through real time data collection, intelligent forecasting and real time routing. The project researches the issues for allowing Australian Road Traffic Authorities to automatically capture road traffic data, forecast traffic flows and smartly route traffic flows to avoid congestion on road networks. This will lead to several benefits, such as (a) reducing traffic congestion, shorten travel time and lower pollution, (b) better utilization of existing road infrastructure by diffusing traffic to alternate routes, (c) provide economic benefit by allowing one to delay infrastructure expansion, (d) monitoring of aberrant behaviour by road users to ensure a safer road environment, and (e) improved flexibility in deployment of the Wireless Sensor Network to meet the needs of the road authorities and community.Read moreRead less
Barriers for cost - effective rock fall hazard mitigation. Rock fall barriers are used throughout Australia to protect its extensive road and rail networks. These networks are vital links in the nation's infrastructure and underpin its economic prosperity and development. There are thousands of cuttings on Australia' transport networks, many of which have the potential to be affected by rock falls. These events can take lives and severely disrupt the performance of our transport infrastructure. ....Barriers for cost - effective rock fall hazard mitigation. Rock fall barriers are used throughout Australia to protect its extensive road and rail networks. These networks are vital links in the nation's infrastructure and underpin its economic prosperity and development. There are thousands of cuttings on Australia' transport networks, many of which have the potential to be affected by rock falls. These events can take lives and severely disrupt the performance of our transport infrastructure. This project will develop new cost-effective methods for designing against rock fall events using a combination of advanced testing and computer modelling.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0561030
Funder
Australian Research Council
Funding Amount
$441,100.00
Summary
Developmental Imaging Facility. This application seeks to establish a facility to undertake expression profiling in vertebrate tissues on a genomic scale and at the highest resolution. Undertaking large scale projects of this nature requires specialised robotics and dedicated infrastructure for microscopy and tissue preparation. This facility will be the first of its type in Australia will permit researchers to perform genomic scale in situ screens, many as part of large international initiative ....Developmental Imaging Facility. This application seeks to establish a facility to undertake expression profiling in vertebrate tissues on a genomic scale and at the highest resolution. Undertaking large scale projects of this nature requires specialised robotics and dedicated infrastructure for microscopy and tissue preparation. This facility will be the first of its type in Australia will permit researchers to perform genomic scale in situ screens, many as part of large international initiatives in developmental and cellular biology. This large-scale, high-resolution expression profiling infrastructure is required to maintain international competitiveness and will dramatically improve our gene discovery, functional assessment and understanding of vertebrate development.Read moreRead less
Predicting scour and scour-induced settlement of subsea infrastructure. This project aims to develop improved predictions and understanding of the potential and extent of scour and scour-induced settlement of subsea infrastructure on mobile seabeds. This is expected to enable scour and settlement to be accounted for directly in engineering stability and serviceability design, overturning current practice which ignores both effects on the basis of using scour protection and costly maintenance and ....Predicting scour and scour-induced settlement of subsea infrastructure. This project aims to develop improved predictions and understanding of the potential and extent of scour and scour-induced settlement of subsea infrastructure on mobile seabeds. This is expected to enable scour and settlement to be accounted for directly in engineering stability and serviceability design, overturning current practice which ignores both effects on the basis of using scour protection and costly maintenance and remediation. Development of accurate predictions is expected to be achieved through physical model testing, numerical modelling and analysis of field data. Predictions should improve subsea reliability and lead to omission of scour protection in some situations, increasing international competitiveness of our offshore oil and gas industry.Read moreRead less
Securing Australian floating wind developments with helical anchors. This project will reduce the cost of offshore floating wind energy by uniting leading academic expertise and innovative industry partners to develop the knowledge and practical tools that will enable the deployment of helical anchors as a cheap and reliable anchoring system for floating wind. Helical anchors are seen as the most promising solution to anchor wind turbines, but their deployment has been limited by uncertainties a ....Securing Australian floating wind developments with helical anchors. This project will reduce the cost of offshore floating wind energy by uniting leading academic expertise and innovative industry partners to develop the knowledge and practical tools that will enable the deployment of helical anchors as a cheap and reliable anchoring system for floating wind. Helical anchors are seen as the most promising solution to anchor wind turbines, but their deployment has been limited by uncertainties associated with the torque and vertical force required for installation in complex seabeds, and their performance under environmental loading. The project will address these specific points through a combination of physical, numerical and analytical modelling, using data and design scenarios provided by industry.
Read moreRead less
Industrial Transformation Training Centres - Grant ID: IC230100015
Funder
Australian Research Council
Funding Amount
$5,000,000.00
Summary
ARC Training Centre for Whole Life Design of Carbon Neutral Infrastructure. This Centre aims to transform the capability of civil infrastructure stakeholders to design, construct, operate and dispose of infrastructure in a carbon neutral way. By training industry-embedded PhDs and postdocs in the methodology and technology required to design out excess carbon of infrastructure in its whole life, this Centre expects to lead the world in sustainable infrastructure design, enabling a new generation ....ARC Training Centre for Whole Life Design of Carbon Neutral Infrastructure. This Centre aims to transform the capability of civil infrastructure stakeholders to design, construct, operate and dispose of infrastructure in a carbon neutral way. By training industry-embedded PhDs and postdocs in the methodology and technology required to design out excess carbon of infrastructure in its whole life, this Centre expects to lead the world in sustainable infrastructure design, enabling a new generation of infrastructure design in Australia and internationally. Achieving carbon neutral infrastructure in its whole life will bring significant far-reaching benefits, including equipping industry with tools required to meet Australia’s emission reduction targets as well as economic, commercial, environmental, and social gains.Read moreRead less