ARC Centre for Complex Systems. The Australian Centre for Complex Systems brings together leading researchers from several disciplines and institutions to conduct research on questions fundamental to understanding and managing complex systems. Its core research program, based on the theme of computation in and by networks of agents, has two interwoven strands. The science strand addresses questions about emergent properties, natural computation, and nonlinear dynamics. The engineering strand add ....ARC Centre for Complex Systems. The Australian Centre for Complex Systems brings together leading researchers from several disciplines and institutions to conduct research on questions fundamental to understanding and managing complex systems. Its core research program, based on the theme of computation in and by networks of agents, has two interwoven strands. The science strand addresses questions about emergent properties, natural computation, and nonlinear dynamics. The engineering strand addresses issues about methodology, modelling toolkits, and management and control. Practical applications are advanced via collaborative projects that address key issues in biology, environment, and socio-economics.Read moreRead less
Disulfide Bonds and Protein Folding. This work will advance our understanding of protein folding, which has important implications in biotechnology, impacting on commercial production of recombinant proteins (for pharmaceutical and biomedical applications) and on 1000s of research laboratories worldwide that use recombinant technologies. This research could also contribute to medicine (new treatments for diseases of protein misfolding like Alzheimer's), and to membrane protein structural biology ....Disulfide Bonds and Protein Folding. This work will advance our understanding of protein folding, which has important implications in biotechnology, impacting on commercial production of recombinant proteins (for pharmaceutical and biomedical applications) and on 1000s of research laboratories worldwide that use recombinant technologies. This research could also contribute to medicine (new treatments for diseases of protein misfolding like Alzheimer's), and to membrane protein structural biology. This work could yield economic benefits in the long-term through patentable outcomes and will benefit the community by producing high impact research papers, providing training to Australians and forging links with renowned international scientists.Read moreRead less
Contaminant Transport in Marine Sediment. Sediments in bays and estuaries are often contaminated. The inorganic contaminants in sediments can be released back into the water body through mass transfer processes. The mass transfer rate is largely controlled by the wave-driven seepage flux across the seabed. Quantification of this flux is thus a key factor in modelling water quality of coastal water bodies. This project aims to: (1) develop models forwave-induced seepage flux within sediments and ....Contaminant Transport in Marine Sediment. Sediments in bays and estuaries are often contaminated. The inorganic contaminants in sediments can be released back into the water body through mass transfer processes. The mass transfer rate is largely controlled by the wave-driven seepage flux across the seabed. Quantification of this flux is thus a key factor in modelling water quality of coastal water bodies. This project aims to: (1) develop models forwave-induced seepage flux within sediments and contaminant transport; and (2) establish the link between seepage flux and contaminant transport. Outcomes of the proposed research will enhance the understanding of the mechanism of contaminant transport in marine sediment.Read moreRead less
Poro-elastic, single domain model of wave-induced transport and transformation of pollutants in coastal sediments. The sediments in many bays and estuaries in Australia are contaminated by pollutants due to discharge of waste from the river, groundwater or/and ocean outfall. Most previous research has had a multi-domain approach and have ignored the wave-dirven advective flow and effects of soil behaviour in coastal sediment. In this study, we will couple the procedure of pollutant transport ne ....Poro-elastic, single domain model of wave-induced transport and transformation of pollutants in coastal sediments. The sediments in many bays and estuaries in Australia are contaminated by pollutants due to discharge of waste from the river, groundwater or/and ocean outfall. Most previous research has had a multi-domain approach and have ignored the wave-dirven advective flow and effects of soil behaviour in coastal sediment. In this study, we will couple the procedure of pollutant transport near the sediment-water interface by a single domain approach, and link wave-dirven advective flow and contaminant in marine sediments. The research outcomes will provide a better prediction of the transformation behaviour of pollutants in contaminated sediments.Read moreRead less
Rigorous Three Dimensional Plasticity Solutions for Soil and Rock Slopes. Slope failures and landslides are a persistent cause of economic loss in Australia. Damages resulting from landslides include both property damage and loss of life. One such recent catastrophic slope failure is the landslide that occurred at Thredbo Village in New South Wales in 1997. This monumental landslide resulted in the deaths of 18 people and was considered by the coroner as the worst natural disaster in Australian ....Rigorous Three Dimensional Plasticity Solutions for Soil and Rock Slopes. Slope failures and landslides are a persistent cause of economic loss in Australia. Damages resulting from landslides include both property damage and loss of life. One such recent catastrophic slope failure is the landslide that occurred at Thredbo Village in New South Wales in 1997. This monumental landslide resulted in the deaths of 18 people and was considered by the coroner as the worst natural disaster in Australian history. The primary aim of this research project is to apply recently developed computational tools to better understand 3D slope behaviour and to develop rigorous stability solutions that can be used by design engineers. A better understanding of 3D slope failure will lead to more economic and safer slope designs.Read moreRead less
Modelling of sand wave migration and its interaction with pipelines. The movement of sand due to sand waves can interfere with marine structures such as pipelines and cables on the seabed. It may also cause free spans of pipelines, with potentially serious consequences. Most previous research has considered sand wave propagation and the stability of pipelines as separate problems. In this project, we propose a coupled analysis of sand wave migration and its interaction with pipelines through mat ....Modelling of sand wave migration and its interaction with pipelines. The movement of sand due to sand waves can interfere with marine structures such as pipelines and cables on the seabed. It may also cause free spans of pipelines, with potentially serious consequences. Most previous research has considered sand wave propagation and the stability of pipelines as separate problems. In this project, we propose a coupled analysis of sand wave migration and its interaction with pipelines through mathematical and numerical modelling. The theoretical work will be supported by laboratory experiments. The resulting research will provide a better understanding of sand wave migration, beach profiles and the stability of pipelines.Read moreRead less
Coupling models for ocean waves, groundwater and porous seabeds interaction. The ocean waves, groundwater flow and porous seabeds interaction problem is vital for erosion control, saltily and biological activities in coastal regions. Most previous research has investigated the problem from individual aspects, rather than a coupling concept. In this study, we will develop advanced theoretical models for procedures of waves propagation, water table fluctuations and soil behaviour in a porous seabe ....Coupling models for ocean waves, groundwater and porous seabeds interaction. The ocean waves, groundwater flow and porous seabeds interaction problem is vital for erosion control, saltily and biological activities in coastal regions. Most previous research has investigated the problem from individual aspects, rather than a coupling concept. In this study, we will develop advanced theoretical models for procedures of waves propagation, water table fluctuations and soil behaviour in a porous seabed, and couple them in a model. A series of experiments will be conducted for the verification of the theoretical findings. The research outcomes will provide a better understanding of the interaction between ocean wave, groundwater flow and porous seabeds.Read moreRead less
Tidal watertable fluctuation in a sandy ocean beach. Tidal dynamics in a sandy beach is important for erosion, saltwater intrusion and biological activities. Most previous researches were based on linearised shallow flow, ignoring capillary effects and soil behaviour, which are particularly important for a sandy beach. In this project, we propose to establish an analytical approximation for the tidal watertable fluctuation in a sandy beach by incorporate the capillary effects and soil behaviour. ....Tidal watertable fluctuation in a sandy ocean beach. Tidal dynamics in a sandy beach is important for erosion, saltwater intrusion and biological activities. Most previous researches were based on linearised shallow flow, ignoring capillary effects and soil behaviour, which are particularly important for a sandy beach. In this project, we propose to establish an analytical approximation for the tidal watertable fluctuation in a sandy beach by incorporate the capillary effects and soil behaviour. The analytical work will be supported by numerical and laboratory experiments. The research outcomes will provide a better understanding in tidal waves, beaches and groundwater interaction and also establish a long-term collaboration between two institutes.Read moreRead less
In vitro expression and crystallization of proteins from the thermohalophile, Halothermothrix orenii. The project proposal is to develop enabling state-of-the-art protein technologies for biotechnology. We will for the first time develop a rapid and high throughput technique for the expression, purification and crystallisation of proteins from the extreme thermohalophile, Halothermothrix orenii. This important break through in protein technology will assist in determining structure and function ....In vitro expression and crystallization of proteins from the thermohalophile, Halothermothrix orenii. The project proposal is to develop enabling state-of-the-art protein technologies for biotechnology. We will for the first time develop a rapid and high throughput technique for the expression, purification and crystallisation of proteins from the extreme thermohalophile, Halothermothrix orenii. This important break through in protein technology will assist in determining structure and function relationships of thermohalophilic proteins. It is expected that such an understanding together with comparative bioinformatics will assist researchers to develop "designer proteins" with improved functions for different uses in biotechnology. It is also expected that this technology will be amenable for use with other thermohalophilic microbes.Read moreRead less
Role of Reactive Particles in Explosive Emulsions. Concentrated water-in oil explosive emulsions are widely used in the minerals industry because they are cheap, easily detonated and relatively safe to handle. Their explosive energy can be significantly increased when reactive particles are introduced into the emulsion matrix. To do this, the interaction between the solid, oil, and water phases needs to be optimised. This investigation will increase our basic understanding of the physical and ch ....Role of Reactive Particles in Explosive Emulsions. Concentrated water-in oil explosive emulsions are widely used in the minerals industry because they are cheap, easily detonated and relatively safe to handle. Their explosive energy can be significantly increased when reactive particles are introduced into the emulsion matrix. To do this, the interaction between the solid, oil, and water phases needs to be optimised. This investigation will increase our basic understanding of the physical and chemical interactions that occur between the particle and the oil-water interface, and develop a more efficient explosive that can be produced continuously on a commercial scale.Read moreRead less