New Techniques for Structural Biology and Directed Molecular Evolution. This PhD program will equip an Australian graduate with advanced training in techniques in molecular genetics and protein chemistry that are currently in high demand by the biotechnology industry, and also provide him/her with direct experience of an industrial R&D laboratory environment. Moreover, it will establish a basis for further collaboration between a leading University-based research laboratory and an established R& ....New Techniques for Structural Biology and Directed Molecular Evolution. This PhD program will equip an Australian graduate with advanced training in techniques in molecular genetics and protein chemistry that are currently in high demand by the biotechnology industry, and also provide him/her with direct experience of an industrial R&D laboratory environment. Moreover, it will establish a basis for further collaboration between a leading University-based research laboratory and an established R&D company that will lead to development of new techniques for use in biotechnology in Australia and overseas.Read moreRead less
Recovery and characterization of monooxygenases for biocatalysis and bioremediation through development of novel DNA- and protein-based technology. Australia contains hundreds of sites contaminated with toxic waste and judged to pose significant risk of harm to the public. This project will identify enzymes and organisms capable of remediating such contaminated sites by natural processes. It will also result in training of persons and development of techniques that will contribute to making bi ....Recovery and characterization of monooxygenases for biocatalysis and bioremediation through development of novel DNA- and protein-based technology. Australia contains hundreds of sites contaminated with toxic waste and judged to pose significant risk of harm to the public. This project will identify enzymes and organisms capable of remediating such contaminated sites by natural processes. It will also result in training of persons and development of techniques that will contribute to making bioremediation an environmentally sustainable and cost-effective technology. The environmental proteomics strategy is a frontier technology, expected to have broad applications in health, food science and the environment. Our development of this technology will create a wide range of opportunities for Australian scientists and companies.Read moreRead less
Indian Sandalwood: genetic and oil diversity, and oil biochemistry of the Australian germplasm collection. The main aim is to improve the commerciality of the sandalwood industry in tropical Australia through smarter tree selection and breeding by development of knowledge of oil quality and quantity, oil biochemistry and DNA marker-assisted selection of the germplasm collection available in Australia.
ARC Centre for Complex Systems. The Australian Centre for Complex Systems brings together leading researchers from several disciplines and institutions to conduct research on questions fundamental to understanding and managing complex systems. Its core research program, based on the theme of computation in and by networks of agents, has two interwoven strands. The science strand addresses questions about emergent properties, natural computation, and nonlinear dynamics. The engineering strand add ....ARC Centre for Complex Systems. The Australian Centre for Complex Systems brings together leading researchers from several disciplines and institutions to conduct research on questions fundamental to understanding and managing complex systems. Its core research program, based on the theme of computation in and by networks of agents, has two interwoven strands. The science strand addresses questions about emergent properties, natural computation, and nonlinear dynamics. The engineering strand addresses issues about methodology, modelling toolkits, and management and control. Practical applications are advanced via collaborative projects that address key issues in biology, environment, and socio-economics.Read moreRead less
Disulfide Bonds and Protein Folding. This work will advance our understanding of protein folding, which has important implications in biotechnology, impacting on commercial production of recombinant proteins (for pharmaceutical and biomedical applications) and on 1000s of research laboratories worldwide that use recombinant technologies. This research could also contribute to medicine (new treatments for diseases of protein misfolding like Alzheimer's), and to membrane protein structural biology ....Disulfide Bonds and Protein Folding. This work will advance our understanding of protein folding, which has important implications in biotechnology, impacting on commercial production of recombinant proteins (for pharmaceutical and biomedical applications) and on 1000s of research laboratories worldwide that use recombinant technologies. This research could also contribute to medicine (new treatments for diseases of protein misfolding like Alzheimer's), and to membrane protein structural biology. This work could yield economic benefits in the long-term through patentable outcomes and will benefit the community by producing high impact research papers, providing training to Australians and forging links with renowned international scientists.Read moreRead less
Progressive liquefaction within marine sediments: comparison between geo-centrifuge modelling, full-scale wave tank tests and numerical modelling. The evaluation of wave-induced liquefaction within the marine sediment is particularly important for coastal and geotechnical engineers involved in the design of foundation around coastal structures. The proposed study will integrate the existing knowledge from the aspects of coastal and geotechnical engineering with that of overseas experts to provid ....Progressive liquefaction within marine sediments: comparison between geo-centrifuge modelling, full-scale wave tank tests and numerical modelling. The evaluation of wave-induced liquefaction within the marine sediment is particularly important for coastal and geotechnical engineers involved in the design of foundation around coastal structures. The proposed study will integrate the existing knowledge from the aspects of coastal and geotechnical engineering with that of overseas experts to provide coastal engineers with an effective tool for the design of foundations around marine structures. It will also assist in reducing the risk of potential environmental damage caused by failure of marine structures.Read moreRead less
Mathematical and mechanical modeling of nano particulate flow. Nano particulates are the basis for many new technologies, including coatings in the electronics industry, composite materials and medical and pharmaceutical applications. Worldwide industrial competition is increasingly determined by our capacity to handle such highly cohesive materials, and to exploit their novel physical, chemical and mechanical characteristics. Devising handling mechanisms and understanding nano particulate flows ....Mathematical and mechanical modeling of nano particulate flow. Nano particulates are the basis for many new technologies, including coatings in the electronics industry, composite materials and medical and pharmaceutical applications. Worldwide industrial competition is increasingly determined by our capacity to handle such highly cohesive materials, and to exploit their novel physical, chemical and mechanical characteristics. Devising handling mechanisms and understanding nano particulate flows depends on formulating accurate mathematical models which reflect the correct underlying physics. This APF proposal will utilise advanced continuum mechanics to develop the correct underlying conceptual ideas to resolve fundamental nanomechanical particulate flows, which will lead to the next generation of engineering tools.
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Geotechnical characterisation of compacted ground based on passive ambient noise techniques. The proposed research will provide our local construction and mining industries with a much needed fast and low cost technology for geotechnical investigation of very large sites which is currently not available. The project will help steer Australia to the forefront of ambient noise research for geotechnical site investigation, in the characterisation of unsaturated compacted soil and in the determinati ....Geotechnical characterisation of compacted ground based on passive ambient noise techniques. The proposed research will provide our local construction and mining industries with a much needed fast and low cost technology for geotechnical investigation of very large sites which is currently not available. The project will help steer Australia to the forefront of ambient noise research for geotechnical site investigation, in the characterisation of unsaturated compacted soil and in the determination of dynamic site characteristics which are required for seismic risk assessment. Two postgraduate students will benefit from this research by receiving research training at the highest level and it will also pave the way for exporting the technology developed overseas, particularly to our near neighbours in Asia and the Pacific. Read moreRead less
Response of residential structures to blast vibration. This proposed project combines the expertise and disciplines of residential construction, structural dynamics and blasting technology. The ultimate aim of the project is to develop a rational methodology for assessing the damage potential of ground vibration resulting from blasting on typical Australian residential structures. The project involves field blast vibration measurements, static and dynamic laboratory tests on structural sub-assem ....Response of residential structures to blast vibration. This proposed project combines the expertise and disciplines of residential construction, structural dynamics and blasting technology. The ultimate aim of the project is to develop a rational methodology for assessing the damage potential of ground vibration resulting from blasting on typical Australian residential structures. The project involves field blast vibration measurements, static and dynamic laboratory tests on structural sub-assemblages in a controlled environment, and comprehensive analytical modelling of both loading and response. The outcomes from this research will have direct application to the mining, insurance, construction and defence industries.Read moreRead less
Assessment and Prediction of Particle Breakage under Cyclic Loading. Every year, transport industries spend millions of dollars to maintain existing tracks suffering excessive settlement due to heavy traffic. In railways, differential settlement and track fouling are mostly due to ballast breakage. Frequent maintenance requires large amounts of quarried ballast causing environmental degradation. Simulation of particle breakage subject to cyclic loading is pioneering fundamental research that wi ....Assessment and Prediction of Particle Breakage under Cyclic Loading. Every year, transport industries spend millions of dollars to maintain existing tracks suffering excessive settlement due to heavy traffic. In railways, differential settlement and track fouling are mostly due to ballast breakage. Frequent maintenance requires large amounts of quarried ballast causing environmental degradation. Simulation of particle breakage subject to cyclic loading is pioneering fundamental research that will have significant impact on the design and maintenance of future rail and road networks. A full understanding of the breakage mechanisms of aggregates will lead to innovative techniques in design and construction, including faster trains carrying heavier loads with reduced maintenance costs.Read moreRead less