Discovery of novel microRNA biogenesis and functional components. Discovery of novel microRNA components will provide new strategies for confronting a diverse array of challenges Australia faces, such as the increasing rates of certain cancers in our population, to stresses on our crop plants faced with environmental changes. The biological mechanisms underlying these disparate problems are unified by microRNA involvement in many instances. By finding microRNA controlling factors common to all h ....Discovery of novel microRNA biogenesis and functional components. Discovery of novel microRNA components will provide new strategies for confronting a diverse array of challenges Australia faces, such as the increasing rates of certain cancers in our population, to stresses on our crop plants faced with environmental changes. The biological mechanisms underlying these disparate problems are unified by microRNA involvement in many instances. By finding microRNA controlling factors common to all higher organisms, we expect our community will benefit from the increased knowledge base that will help our researchers adopt new strategies in fighting diseases and improving our agricultural industry.Read moreRead less
A Longitudinal Study Of Psychopathology In People With Intellectual Disability
Funder
National Health and Medical Research Council
Funding Amount
$999,803.00
Summary
This project will further develop the research opportunities of an internationally unique 15 year follow up study of the mental health of young Australians with ID. We have shown that this group has 2-3 times the risk of suffering serious emotional and behavioural problems that are an added heavy burden on the individual, their family and carers and the community. These problems often are not recognised but are as common as schizophrenia in the community. The study will continue to use a combina ....This project will further develop the research opportunities of an internationally unique 15 year follow up study of the mental health of young Australians with ID. We have shown that this group has 2-3 times the risk of suffering serious emotional and behavioural problems that are an added heavy burden on the individual, their family and carers and the community. These problems often are not recognised but are as common as schizophrenia in the community. The study will continue to use a combination of questionnaire survey and in depth interviews of the young adults and their families or carers to track the course of their mental health. The study commenced in 1990 with nearly 1000 young people with ID aged 4-18 years and their progress has been reviewed every 2-3 years in over 75% of the original group. During the next 5 years we plan to follow their mental health during the critical stage of young adult life. During this time there is the greatest risk of mental illnesses such as depression and schizophrenia and the stresses of adjusting to new daily occupations, independent living or residential care and social contact away from the family. We will be able to study the specific emotional and behavioural problems faced by young adults with the main known causes of ID such as Down, Fragile X, Prader Willi and William Syndromes, as well as those who have autism. The great benefit of a long term follow up study is that it allows us to study the links between earlier family environmental, psychological and biological factors and subsequent mental health problems. We can also demonstrate the impact that mental illness in a young person with ID has on the family and parental mental health. The findings have implications for better diagnosis, improved care and management, early intervention and prevention of these common severe and under recognized mental health problems in this disadvantaged group of young Australians and their families and carers.Read moreRead less
Design of dynamic visual signals. Models of the design of visual signals depend heavily upon analyses of static ornaments. Nothing is known about dynamic visual signals. We will use an array of new techniques to tackle this problem for the first time. Motion analyses will define the task faced by the visual system. Sensory limitations will be measured to identify constraints on signal evolution. Digital video playback studies will assess recognition and explain aspects of signal design. Results ....Design of dynamic visual signals. Models of the design of visual signals depend heavily upon analyses of static ornaments. Nothing is known about dynamic visual signals. We will use an array of new techniques to tackle this problem for the first time. Motion analyses will define the task faced by the visual system. Sensory limitations will be measured to identify constraints on signal evolution. Digital video playback studies will assess recognition and explain aspects of signal design. Results will test the generality of principles that have been developed in studies of female mate choice and extend these ideas to address intra-sexual selection operating through opponent assessment.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0561251
Funder
Australian Research Council
Funding Amount
$150,887.00
Summary
Facility for Analyses of Evolutionary Immunology. Our understanding of how selection in natural populations shape (favour and disfavour) immunity, and how this process contribute to organismal (including human) fitness, is rudimentary. In order to study such processes our collective experience strongly suggests and increasing need for geographic amalgamation of necessary and complementary molecular and biomedical techniques. We therefore request funding to establish a collaborative research labo ....Facility for Analyses of Evolutionary Immunology. Our understanding of how selection in natural populations shape (favour and disfavour) immunity, and how this process contribute to organismal (including human) fitness, is rudimentary. In order to study such processes our collective experience strongly suggests and increasing need for geographic amalgamation of necessary and complementary molecular and biomedical techniques. We therefore request funding to establish a collaborative research laboratory in a novel research field - Evolutionary Immuno-Ecology- in which all vital aspects, from a mechanistic to an evolutionary level, can be studied at one research centre.Read moreRead less
Learned Academies Special Projects - Grant ID: LA170100022
Funder
Australian Research Council
Funding Amount
$118,098.00
Summary
Nourishing Australia: a decadal plan for nutrition science. This project aims to develop a plan to address the complex health and environmental challenges associated with changes in food production and consumption. Since the industrial revolution, our understanding of human diet has lagged behind the rate of change. This project aims to better integrate knowledge across nutrients, foods, meals, diets, and dietary patterns to understand balance rather than single nutrients or commodities. It will ....Nourishing Australia: a decadal plan for nutrition science. This project aims to develop a plan to address the complex health and environmental challenges associated with changes in food production and consumption. Since the industrial revolution, our understanding of human diet has lagged behind the rate of change. This project aims to better integrate knowledge across nutrients, foods, meals, diets, and dietary patterns to understand balance rather than single nutrients or commodities. It will examine the broader context of nutrition from individuals to communities to nations, and globally, and develop a consistent theoretical framework for nutrition that includes both individual biology and the physical, social and biological environment. This will provide broad benefits for social, cultural, economic and health outcomes in the region.Read moreRead less
Using Mathematics to Maximize the Efficiency of Shared Infrastructure in Australia's Coal Export Supply Chain. Port Waratah Coal Services operates the world's largest coal export terminal, servicing about 14 coal mining companies in the Hunter Valley, NSW. It is responsible for around $15 billion in annual export income for Australia. The coal supply chain is a complex operation, hampered by bottlenecks in critical shared infrastructure. Such limitations are estimated to cost Australia about $2 ....Using Mathematics to Maximize the Efficiency of Shared Infrastructure in Australia's Coal Export Supply Chain. Port Waratah Coal Services operates the world's largest coal export terminal, servicing about 14 coal mining companies in the Hunter Valley, NSW. It is responsible for around $15 billion in annual export income for Australia. The coal supply chain is a complex operation, hampered by bottlenecks in critical shared infrastructure. Such limitations are estimated to cost Australia about $2 billion pa in lost sales. This project will support the design of new infrastructure and processes to ensure an efficient supply chain. The new science resulting will benefit other coal operations in Australia, and potentially other bulk goods supply chains.Read moreRead less
Improving external validity of stated choice experiments. This project aims to deliver more accurate estimates of choice behaviour by reducing biases due to choice task complexity in surveys as well as design artefacts. Extracting 'true' preferences is challenging, not only due to possible hypothetical bias, but also due to increasingly complex choice tasks and the existence of design artefacts. This project will investigate the latter two in the context of marketing, transport, health, and envi ....Improving external validity of stated choice experiments. This project aims to deliver more accurate estimates of choice behaviour by reducing biases due to choice task complexity in surveys as well as design artefacts. Extracting 'true' preferences is challenging, not only due to possible hypothetical bias, but also due to increasingly complex choice tasks and the existence of design artefacts. This project will investigate the latter two in the context of marketing, transport, health, and environmental economics, and proposes new methodologies to extract preferences that more closely reflect true behaviour in real markets.Read moreRead less
Quantifying the role of the Southern Ocean for anthropogenic CO2 uptake. Carbon dioxide (CO2) is the most important greenhouse gas contributing to global warming and climate change. Climate change is likely to have dramatic economic and environmental consequences for Australia. Knowledge and understanding of the complex carbon cycle is fundamental for predicting future atmospheric CO2 levels and managing climate change. The aim of the work proposed here is to quantify and improve our understan ....Quantifying the role of the Southern Ocean for anthropogenic CO2 uptake. Carbon dioxide (CO2) is the most important greenhouse gas contributing to global warming and climate change. Climate change is likely to have dramatic economic and environmental consequences for Australia. Knowledge and understanding of the complex carbon cycle is fundamental for predicting future atmospheric CO2 levels and managing climate change. The aim of the work proposed here is to quantify and improve our understanding of the oceans role in controlling atmospheric CO2 levels. This will be done by combining modeling and observational expertise among UNSW and CSIRO (Marine Research) researchers. Our work will be the first to assess the extent of which the Southern Ocean (and Australian waters) acts as a carbon sink. This will reduce modeling uncertainties in predicting future atmospheric CO2 levels and will also be valuable to the federal government in future international negotiations on climate change.Read moreRead less
Stable on-demand optimization for workforce and fleet logistics management. This project aims to conceive, develop and deploy innovative methodologies for stable on-demand workforce management and fleet logistics based on advanced decision-support systems. The outcome of this project will provide a new cloud-based real-time Optimisation Software-as-a-Service (OSaaS) platform that allows businesses to improve their productivity while reducing operating costs and their environmental footprint. Thi ....Stable on-demand optimization for workforce and fleet logistics management. This project aims to conceive, develop and deploy innovative methodologies for stable on-demand workforce management and fleet logistics based on advanced decision-support systems. The outcome of this project will provide a new cloud-based real-time Optimisation Software-as-a-Service (OSaaS) platform that allows businesses to improve their productivity while reducing operating costs and their environmental footprint. This is expected to support the manufacturing, retail, delivery and mobile fleets industries.Read moreRead less
The Role And Inheritance Of Constitutional Epimutations In Early-onset Colorectal Cancer.
Funder
National Health and Medical Research Council
Funding Amount
$347,551.00
Summary
Traditionally familial cancers are thought to be caused by spelling mistakes within the genetic code of cancer prevention genes. Our group has found that chemical attachments to one gene (MLH1) stops it working, even where there is no spelling mistake, and that those chemical changes can be inherited in families with bowel cancer. We will determine how frequently this type of defect occurs in bowel cancer patients, how and why it arises, and if other cancer genes are similarly affected.