Ensuring The Utility And Sustainability Of Tissue Banks: Supporting Translational Research In Australia Through Informed Regulation And Community Engagement.
Funder
National Health and Medical Research Council
Funding Amount
$481,885.00
Summary
Tissue banks provide a critical resource for translational research into the causes and treatment of many diseases affecting children and adults, such as cancer.Their success and contribution to medical research depends on addressing the many unresolved and emerging challenges that impact their work. This is the first national empirical study engaging the Australian research community, legal experts tissue donors and the public about the challenges to tissue banks to inform ethico legal regulati ....Tissue banks provide a critical resource for translational research into the causes and treatment of many diseases affecting children and adults, such as cancer.Their success and contribution to medical research depends on addressing the many unresolved and emerging challenges that impact their work. This is the first national empirical study engaging the Australian research community, legal experts tissue donors and the public about the challenges to tissue banks to inform ethico legal regulation and deliver better health care systems.Read moreRead less
Self-destructing CRISPR-constructs For Targeted Genome Editing In The Retina.
Funder
National Health and Medical Research Council
Funding Amount
$679,926.00
Summary
Despite the identification of specific mutations causing many inherited retinal dystrophies, all of these conditions are currently untreatable. We have established gene-editing techniques and have developed a novel mouse model, which will serve as a robust platform for testing different techniques of gene editing in the retina. No other group in the world is known to be using this platform for gene editing and our work will expedite the clinical translation of this technology.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0454133
Funder
Australian Research Council
Funding Amount
$101,000.00
Summary
Upgrade of Infrared Analytical Facility. This application seeks funding to upgrade the existing infrared analytical facility in the Central Science Laboratory (CSL) by installing a near infrared analyser.This instrument will provide analytical support to researchers in the fields of silviculture, agriculture and chemistry by providing a low cost, rapid and accurate analysis of the chemical and physical properties of large sample numbers.This instrument will dramatically reduce the project costs, ....Upgrade of Infrared Analytical Facility. This application seeks funding to upgrade the existing infrared analytical facility in the Central Science Laboratory (CSL) by installing a near infrared analyser.This instrument will provide analytical support to researchers in the fields of silviculture, agriculture and chemistry by providing a low cost, rapid and accurate analysis of the chemical and physical properties of large sample numbers.This instrument will dramatically reduce the project costs, compared with traditional wet analytical methods,and enable larger and statistically more significant data sets to be acquired.The expected outcomes will include a more rapid identification of the genes controlling plant characteristics and the development of targeted plant breeding programs of economic significance to Australia.The development of specific resins for gold extraction will be both economically and environmentally important.Read moreRead less
Developing Evidence Based Strategies For Addressing Childhood Vaccination Rejection
Funder
National Health and Medical Research Council
Funding Amount
$743,927.00
Summary
Parental rejection of vaccines is a global concern that threatens to undermine disease control. A lack of evidence hampers the responses to this complex and persistent problem. We will interview parents who don’t vaccinate their children to learn what influences their decisions. We will then hold community juries and a public engagement process to refine strategies for responding to vaccination rejection that are acceptable to a well informed citizenry, practical and ethically justified.
Quantitative genetics of Eucalyptus globulus. Eucalypt plantations in Australia have expanded rapidly over the last decade. With increasing market competition from overseas plantations for both pulp and solid wood products, Australia must maintain a competitive edge through efficiencies in production and product quality. Breeding and deployment of genetically superior planting stock is part of the solution. With global climate chance and requirements for re-afforestation in drier zones, there ....Quantitative genetics of Eucalyptus globulus. Eucalypt plantations in Australia have expanded rapidly over the last decade. With increasing market competition from overseas plantations for both pulp and solid wood products, Australia must maintain a competitive edge through efficiencies in production and product quality. Breeding and deployment of genetically superior planting stock is part of the solution. With global climate chance and requirements for re-afforestation in drier zones, there is an increasing requirement to genetically improve drought tolerance. This project will provide genetic information and strategies to back Eucalyptus globulus breeding and deployment programs for traditional as well as drier environments. Read moreRead less
Integrated genetic regulation of photomorphogenesis in Pisum. This project will use a molecular genetic approach in garden pea to investigate the roles of photoreceptors that mediate developmental responses to light. It will define gene families encoding phytochrome, cryptochrome and phototropin photoreceptors, characterise photoreceptor gene expression, and identify mutants with impaired response to light. The mutants will be used in molecular, physiological and biochemical studies to examine h ....Integrated genetic regulation of photomorphogenesis in Pisum. This project will use a molecular genetic approach in garden pea to investigate the roles of photoreceptors that mediate developmental responses to light. It will define gene families encoding phytochrome, cryptochrome and phototropin photoreceptors, characterise photoreceptor gene expression, and identify mutants with impaired response to light. The mutants will be used in molecular, physiological and biochemical studies to examine how photoreceptors control and co-ordinate development throughout the plant via effects on plant hormone synthesis and response. Results from the project will be of practical importance in manipulating key aspects of plant growth to better suit particular environmental and agronomic objectives.Read moreRead less
Molecular tools for understanding, predicting and managing flowering and reproductive development in Brassica oleracea. This project integrates basic research with application to a significant horticultural industry, building on Australia's position as a leader in world research on molecular and genetic regulation of flowering. The project will strengthen Australia's research reputation in this field, provide new tools for cultivar screening in and management of B. oleracea seed crops. The proj ....Molecular tools for understanding, predicting and managing flowering and reproductive development in Brassica oleracea. This project integrates basic research with application to a significant horticultural industry, building on Australia's position as a leader in world research on molecular and genetic regulation of flowering. The project will strengthen Australia's research reputation in this field, provide new tools for cultivar screening in and management of B. oleracea seed crops. The project will deliver training for 3 PhD students at the interface between basic and applied research. A shortage of skilled scientists with ability to link understanding of plant development at the molecular/genetic level with improved crop management practices has been identified by the horticultural sector as a major challenge. Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0561251
Funder
Australian Research Council
Funding Amount
$150,887.00
Summary
Facility for Analyses of Evolutionary Immunology. Our understanding of how selection in natural populations shape (favour and disfavour) immunity, and how this process contribute to organismal (including human) fitness, is rudimentary. In order to study such processes our collective experience strongly suggests and increasing need for geographic amalgamation of necessary and complementary molecular and biomedical techniques. We therefore request funding to establish a collaborative research labo ....Facility for Analyses of Evolutionary Immunology. Our understanding of how selection in natural populations shape (favour and disfavour) immunity, and how this process contribute to organismal (including human) fitness, is rudimentary. In order to study such processes our collective experience strongly suggests and increasing need for geographic amalgamation of necessary and complementary molecular and biomedical techniques. We therefore request funding to establish a collaborative research laboratory in a novel research field - Evolutionary Immuno-Ecology- in which all vital aspects, from a mechanistic to an evolutionary level, can be studied at one research centre.Read moreRead less
The role of plant hormones in arbuscular mycorrhizal symbiosis. The vast majority of plant species can form a beneficial symbiosis with specialised soil fungi, an association that can enhance the uptake of nutrients from the soil, improve tolerance to drought and disease and minimise soil erosion. An understanding of how plants establish and regulate this important symbiosis has the potential to contribute to the development of productive and sustainable farming systems by making efficient use o ....The role of plant hormones in arbuscular mycorrhizal symbiosis. The vast majority of plant species can form a beneficial symbiosis with specialised soil fungi, an association that can enhance the uptake of nutrients from the soil, improve tolerance to drought and disease and minimise soil erosion. An understanding of how plants establish and regulate this important symbiosis has the potential to contribute to the development of productive and sustainable farming systems by making efficient use of the limited water resources, reducing soil erosion, reducing reliance on pesticides and fertilisers and producing more nutritious fruits, vegetables and grains.Read moreRead less
Everyday Incivilities. The study aims to provide the best available evidence on the seriousness of everyday incivilities between strangers in public places as a social problem in Australian society. This will involve gathering self-report data from socially diverse Australians for the purpose of exploring social group differences in (i) the type and prevalence of everyday incivilities experienced, and (ii) the social and psychological costs of exposure to everyday incivilities. The information ....Everyday Incivilities. The study aims to provide the best available evidence on the seriousness of everyday incivilities between strangers in public places as a social problem in Australian society. This will involve gathering self-report data from socially diverse Australians for the purpose of exploring social group differences in (i) the type and prevalence of everyday incivilities experienced, and (ii) the social and psychological costs of exposure to everyday incivilities. The information gathered will be used to identify high risk social groups and public places, and serve as a basis for developing programs for reducing everyday incivilities.Read moreRead less