Psychosocial Aspects Of Genomic Testing For Breast Cancer Risk
Funder
National Health and Medical Research Council
Funding Amount
$108,902.00
Summary
Assessing a woman’s breast cancer risk by profiling polygenic risk represents a new approach in the familial cancer setting. My study is part of a program of research that aims to facilitate translation of polygenic risk information into clinical practice. For this, I will invite 400 women to receive their personal polygenic result and i) assess interest in receiving this result; ii) assess psychological and behavioural outcomes of receiving or not receiving their personal polygenic risk result
Sudden Cardiac Arrest: Improving Detection Of Patients At Risk
Funder
National Health and Medical Research Council
Funding Amount
$838,845.00
Summary
Sudden cardiac death accounts for ~10% of deaths in our community. Many of these deaths occur in people who could otherwise have had many more years of productive life ahead of them. The aim of our research is to determine the underlying mechanisms so that we can develop better tools for detecting underlying problems before they become life threatening and potentially develop new treatments to modify the underlying causes.
The Genetic And Environmental Determinants Of Amyloid Deposition In Older Individuals: An Amyloid Imaging Study Using The Twin Design
Funder
National Health and Medical Research Council
Funding Amount
$643,267.00
Summary
Alzheimer’s disease is characterised by the deposition of amyloid plaques in the brain. We don’t fully understand how amyloid deposition occurs and what contribution is made by genetic and environmental factors. Amyloid deposition in the brain can now be quantified during life using positron emission tomography. In this study, we will examine brain amyloid in twins, which will determine what proportion of the pathology is attributable to environmental factors that may be modifiable.
The overall aim is to improve treatments and outcomes for people with osteoporosis. This will be achieved by better predicting those who are likely to fracture and subsequently those who do well post fracture from those who do poorly. Following an osteoporotic fracture there is an increased risk of re- fracture and of premature death. This research will define those risk factors for fracture, re-fracture and early death in a large group of men and women followed for over 20 years.
Development of a Multi Threat Risk Assessment Model for Critical Infrastructure Using Scripted Agent Computer Technology. Current risk assessment paradigms are not suited to the control of catastrophic events such as terrorism. An advanced approach to risk assessment will be developed in this project for rare high impact events such as bomb blasts, where critical infrastructure is threatened. A new software platform based on scripted agent modelling will be constructed that will allow for state ....Development of a Multi Threat Risk Assessment Model for Critical Infrastructure Using Scripted Agent Computer Technology. Current risk assessment paradigms are not suited to the control of catastrophic events such as terrorism. An advanced approach to risk assessment will be developed in this project for rare high impact events such as bomb blasts, where critical infrastructure is threatened. A new software platform based on scripted agent modelling will be constructed that will allow for state of the art models to be used as agents providing a dynamic risk evaluation and necessary information for actions to infrastructure owners and emergency responders as a threat develops. Both the developed scripted agent and the risk assessment technologies can be applied to other technologies and complex risks, such as waste disposal and biotechnology.Read moreRead less
Development of a Multi Threat Risk Assessment Model for Critical Infrastructure Using Scripted Agent Computer Technology. The project will develop a distributed risk network capable of real time assessment of multiple threats to critical infrastructure, which will guide decision making on the appropriate response as the nature of the threat changes. This will assist all stakeholders and allow an integrated response across industry and government agencies. The developed technology will find read ....Development of a Multi Threat Risk Assessment Model for Critical Infrastructure Using Scripted Agent Computer Technology. The project will develop a distributed risk network capable of real time assessment of multiple threats to critical infrastructure, which will guide decision making on the appropriate response as the nature of the threat changes. This will assist all stakeholders and allow an integrated response across industry and government agencies. The developed technology will find ready application in other areas where integration of science and technology is required to solve complex problems. For example, risk network technology has application to natural hazards, waste disposal and financial markets while the scripted agent has application to communication technologies and sensor networks.Read moreRead less
Extensions to the page scoring algorithm in internet search engine studies. This project proposes to study two extensions to the Page rank equation which is one of the theoretical underpinning of Google's web page scoring engine. In particular, we wish to explore ways to combine page connectivity and page characteristics in the scoring of web pages. This will be the first time a rational way is proposed for combining these two factors. The expected outcome will be a deeper understanding on how t ....Extensions to the page scoring algorithm in internet search engine studies. This project proposes to study two extensions to the Page rank equation which is one of the theoretical underpinning of Google's web page scoring engine. In particular, we wish to explore ways to combine page connectivity and page characteristics in the scoring of web pages. This will be the first time a rational way is proposed for combining these two factors. The expected outcome will be a deeper understanding on how these two factors affect the scores of a web page in a search engine, and hence how they affect the visibility of the page in response to a query.
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Data structures which change with time, a machine learning approach. Visibility of web pages, based on page importance, on the Internet controls their accessibility by users which is critical for e-Commerce applications. The page importance depends on its contents and its link structure to other web pages, both of which can be time varying. This project proposes a novel model in which time varying aspects of the changes to contents and their link structures are captured, thus allowing us a bette ....Data structures which change with time, a machine learning approach. Visibility of web pages, based on page importance, on the Internet controls their accessibility by users which is critical for e-Commerce applications. The page importance depends on its contents and its link structure to other web pages, both of which can be time varying. This project proposes a novel model in which time varying aspects of the changes to contents and their link structures are captured, thus allowing us a better understanding of how these influence the page importance over time. It will also allow us insight on how to improve the visibility of web pages.Read moreRead less
Investigations in Learning Algorithms for Web Page Scoring Systems. Modification of web page scores to satisfy requirements, e.g., one page should have a higher page score than another, a home page should have higher score than any other pages in the same site, using modifications of the forcing function, and the link connectivity matrix respectively of the PageRank equation will be studied. By clustering web pages either by ranks or by scores will help overcome issues of scale and complexity wh ....Investigations in Learning Algorithms for Web Page Scoring Systems. Modification of web page scores to satisfy requirements, e.g., one page should have a higher page score than another, a home page should have higher score than any other pages in the same site, using modifications of the forcing function, and the link connectivity matrix respectively of the PageRank equation will be studied. By clustering web pages either by ranks or by scores will help overcome issues of scale and complexity which are required for the live world wide web. Outcomes will provide a rational basis together with practical methods for modifying web page scores by a web site administrator.Read moreRead less
Uncertain Information Processing for Situation Awareness and Dynamic Decision-Making in Emergency Management. The Australian national counter-terrorism committee indicates that Australia should have a strong intelligence-led prevention and preparedness to support Australia on risk management, emergency services and maintaining capabilities to manage various types of terrorist attacks. The proposed situation awareness support technique can be used to develop situation analysis software systems or ....Uncertain Information Processing for Situation Awareness and Dynamic Decision-Making in Emergency Management. The Australian national counter-terrorism committee indicates that Australia should have a strong intelligence-led prevention and preparedness to support Australia on risk management, emergency services and maintaining capabilities to manage various types of terrorist attacks. The proposed situation awareness support technique can be used to develop situation analysis software systems or directly support Australia government agencies and industries to correctly assess a situation, increase awareness for crisis problems, and therefore improve emergency management and decision-making effectiveness, in particular, for avoiding disaster problems in the first place and preparing plans for those that undoubtedly will occur. Read moreRead less