The ABC, its Archives and its Audiences. This project aims to enable deeper understandings of the role of Australia’s principal public service broadcaster in the lives of audience members across the country, and the community needs and interests that have shaped it. The project, in partnership with the Australian Broadcasting Corporation and the National Archives of Australia, is significant because it will uncover and interpret paper records relating to listeners and viewers during the broadcas ....The ABC, its Archives and its Audiences. This project aims to enable deeper understandings of the role of Australia’s principal public service broadcaster in the lives of audience members across the country, and the community needs and interests that have shaped it. The project, in partnership with the Australian Broadcasting Corporation and the National Archives of Australia, is significant because it will uncover and interpret paper records relating to listeners and viewers during the broadcaster’s first 50 years. Expected outcomes include an enlarged and more discoverable media archive for the benefit of researchers, industry and all Australians; an innovative audience-centred approach to the ABC’s history; and enhanced academic, archival and media collaborations. Read moreRead less
Discovering a ‘good read’: Pathways to reading for Australian teens. This project aims to support the school, library, and book industries to increase teenagers’ recreational reading. Matching the right book to the right reader is essential to increase young people’s motivation to read. Yet how cultural intermediaries should operate to best effect within the complex ecologies that shape young people’s text selection is unclear. The project expects to generate robust evidence on how teens discove ....Discovering a ‘good read’: Pathways to reading for Australian teens. This project aims to support the school, library, and book industries to increase teenagers’ recreational reading. Matching the right book to the right reader is essential to increase young people’s motivation to read. Yet how cultural intermediaries should operate to best effect within the complex ecologies that shape young people’s text selection is unclear. The project expects to generate robust evidence on how teens discover books and the cultural factors that influence their choices. Expected outcomes include strategies that libraries, schools, and the book industry can use to promote Australian content for young adults, and equip young people to participate more fully in the social and economic benefits of pleasure reading.Read moreRead less
Discovery of novel microRNA biogenesis and functional components. Discovery of novel microRNA components will provide new strategies for confronting a diverse array of challenges Australia faces, such as the increasing rates of certain cancers in our population, to stresses on our crop plants faced with environmental changes. The biological mechanisms underlying these disparate problems are unified by microRNA involvement in many instances. By finding microRNA controlling factors common to all h ....Discovery of novel microRNA biogenesis and functional components. Discovery of novel microRNA components will provide new strategies for confronting a diverse array of challenges Australia faces, such as the increasing rates of certain cancers in our population, to stresses on our crop plants faced with environmental changes. The biological mechanisms underlying these disparate problems are unified by microRNA involvement in many instances. By finding microRNA controlling factors common to all higher organisms, we expect our community will benefit from the increased knowledge base that will help our researchers adopt new strategies in fighting diseases and improving our agricultural industry.Read moreRead less
A Longitudinal Study Of Psychopathology In People With Intellectual Disability
Funder
National Health and Medical Research Council
Funding Amount
$999,803.00
Summary
This project will further develop the research opportunities of an internationally unique 15 year follow up study of the mental health of young Australians with ID. We have shown that this group has 2-3 times the risk of suffering serious emotional and behavioural problems that are an added heavy burden on the individual, their family and carers and the community. These problems often are not recognised but are as common as schizophrenia in the community. The study will continue to use a combina ....This project will further develop the research opportunities of an internationally unique 15 year follow up study of the mental health of young Australians with ID. We have shown that this group has 2-3 times the risk of suffering serious emotional and behavioural problems that are an added heavy burden on the individual, their family and carers and the community. These problems often are not recognised but are as common as schizophrenia in the community. The study will continue to use a combination of questionnaire survey and in depth interviews of the young adults and their families or carers to track the course of their mental health. The study commenced in 1990 with nearly 1000 young people with ID aged 4-18 years and their progress has been reviewed every 2-3 years in over 75% of the original group. During the next 5 years we plan to follow their mental health during the critical stage of young adult life. During this time there is the greatest risk of mental illnesses such as depression and schizophrenia and the stresses of adjusting to new daily occupations, independent living or residential care and social contact away from the family. We will be able to study the specific emotional and behavioural problems faced by young adults with the main known causes of ID such as Down, Fragile X, Prader Willi and William Syndromes, as well as those who have autism. The great benefit of a long term follow up study is that it allows us to study the links between earlier family environmental, psychological and biological factors and subsequent mental health problems. We can also demonstrate the impact that mental illness in a young person with ID has on the family and parental mental health. The findings have implications for better diagnosis, improved care and management, early intervention and prevention of these common severe and under recognized mental health problems in this disadvantaged group of young Australians and their families and carers.Read moreRead less
Design of dynamic visual signals. Models of the design of visual signals depend heavily upon analyses of static ornaments. Nothing is known about dynamic visual signals. We will use an array of new techniques to tackle this problem for the first time. Motion analyses will define the task faced by the visual system. Sensory limitations will be measured to identify constraints on signal evolution. Digital video playback studies will assess recognition and explain aspects of signal design. Results ....Design of dynamic visual signals. Models of the design of visual signals depend heavily upon analyses of static ornaments. Nothing is known about dynamic visual signals. We will use an array of new techniques to tackle this problem for the first time. Motion analyses will define the task faced by the visual system. Sensory limitations will be measured to identify constraints on signal evolution. Digital video playback studies will assess recognition and explain aspects of signal design. Results will test the generality of principles that have been developed in studies of female mate choice and extend these ideas to address intra-sexual selection operating through opponent assessment.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0561251
Funder
Australian Research Council
Funding Amount
$150,887.00
Summary
Facility for Analyses of Evolutionary Immunology. Our understanding of how selection in natural populations shape (favour and disfavour) immunity, and how this process contribute to organismal (including human) fitness, is rudimentary. In order to study such processes our collective experience strongly suggests and increasing need for geographic amalgamation of necessary and complementary molecular and biomedical techniques. We therefore request funding to establish a collaborative research labo ....Facility for Analyses of Evolutionary Immunology. Our understanding of how selection in natural populations shape (favour and disfavour) immunity, and how this process contribute to organismal (including human) fitness, is rudimentary. In order to study such processes our collective experience strongly suggests and increasing need for geographic amalgamation of necessary and complementary molecular and biomedical techniques. We therefore request funding to establish a collaborative research laboratory in a novel research field - Evolutionary Immuno-Ecology- in which all vital aspects, from a mechanistic to an evolutionary level, can be studied at one research centre.Read moreRead less
The Role And Inheritance Of Constitutional Epimutations In Early-onset Colorectal Cancer.
Funder
National Health and Medical Research Council
Funding Amount
$347,551.00
Summary
Traditionally familial cancers are thought to be caused by spelling mistakes within the genetic code of cancer prevention genes. Our group has found that chemical attachments to one gene (MLH1) stops it working, even where there is no spelling mistake, and that those chemical changes can be inherited in families with bowel cancer. We will determine how frequently this type of defect occurs in bowel cancer patients, how and why it arises, and if other cancer genes are similarly affected.
CENTRE for INTEGRATIVE LEGUME RESEARCH. Legumes are essential for environmental sustainability and are important for maintaining human health. The Centre combines innovative genomic approaches to investigate the causal phenotypic links required for regulation of legume growth. The unique coexistence of multiple pluripotent meristems in shoots, roots, flowers and nodules permits the discovery of new paradigms governing legume architecture, reproductive differentiation and root-nodule developmen ....CENTRE for INTEGRATIVE LEGUME RESEARCH. Legumes are essential for environmental sustainability and are important for maintaining human health. The Centre combines innovative genomic approaches to investigate the causal phenotypic links required for regulation of legume growth. The unique coexistence of multiple pluripotent meristems in shoots, roots, flowers and nodules permits the discovery of new paradigms governing legume architecture, reproductive differentiation and root-nodule development. New knowledge of the plant growth processes through mechanistic analysis of organ induction provides the tools to optimise the legume's productivity, quality, and environment adaptation.Read moreRead less
Analysing Iterative Machine Learning Algorithms with Information Geometric Methods. Online machine learning problems arise from situations where data is provided a point at a time. There are many classical algorithms for solving such problems based on the principle of stochastic gradient descent. Recent research by the CIs and others have thrown up interesting but diverse geometric connections that offer new insights. The proposed research aims to integrate the understanding of these algori ....Analysing Iterative Machine Learning Algorithms with Information Geometric Methods. Online machine learning problems arise from situations where data is provided a point at a time. There are many classical algorithms for solving such problems based on the principle of stochastic gradient descent. Recent research by the CIs and others have thrown up interesting but diverse geometric connections that offer new insights. The proposed research aims to integrate the understanding of these algorithms with the aim of designing algorithms better able to exploit prior knowledge, and to extend existing algorithms to new problem domains thus offering well principled and well understood algorithms for solving a variety of novel online problems.Read moreRead less
Kernel and Margin Based Machine Learning Algorithms. Certain machine learning algorithms, such as support vector machines, utilizing
the ideas of large margins and kernels have attracted much attention lately
because of their impressive performance on real world problems such as optical
character recognition. We plan to refine and extend such algorithms to a wide
range of different machine learning problems such as gene sequence analysis,
image processing and text classification. Expected ....Kernel and Margin Based Machine Learning Algorithms. Certain machine learning algorithms, such as support vector machines, utilizing
the ideas of large margins and kernels have attracted much attention lately
because of their impressive performance on real world problems such as optical
character recognition. We plan to refine and extend such algorithms to a wide
range of different machine learning problems such as gene sequence analysis,
image processing and text classification. Expected outcomes include the
development of software that allows the solution of hitherto unsolved machine
learning problems, and the ability to solve problems larger than those solvable
by the current generation of machine learning tools.Read moreRead less