Mechanistic characterisation of genotype x environment interactions in sorghum and arabidopsis. Sorghum is an economically important cereal crop for Australia. In Australia, sorghum is used as a staple animal feed and it is very important for the live stock industry. With the predicted changes of temperature and rainfall patterns due to climate change, negative effects on sorghum yield are expected, which can have adverse effects on Australian economy. Our studies will identify and mark genes th ....Mechanistic characterisation of genotype x environment interactions in sorghum and arabidopsis. Sorghum is an economically important cereal crop for Australia. In Australia, sorghum is used as a staple animal feed and it is very important for the live stock industry. With the predicted changes of temperature and rainfall patterns due to climate change, negative effects on sorghum yield are expected, which can have adverse effects on Australian economy. Our studies will identify and mark genes that regulate flowering and seed production in sorghum in response to changes in temperature and light interactions. These studies will help to develop novel sorghum varieties with desirable characters through plant-breeding programmes.Read moreRead less
Regulation of nuclear localisation of the AreA transcription factor in Aspergillus nidulans. An understanding of the means by which the expression of genes is regulated is of fundamental significance. Changes in gene expression are central to the development, growth and viability of all cells and their response to environmental changes/stresses. This study uses the fungus Aspergillus nidulans as an excellent molecular genetic tool to investigate how a key regulatory protein controls gene expres ....Regulation of nuclear localisation of the AreA transcription factor in Aspergillus nidulans. An understanding of the means by which the expression of genes is regulated is of fundamental significance. Changes in gene expression are central to the development, growth and viability of all cells and their response to environmental changes/stresses. This study uses the fungus Aspergillus nidulans as an excellent molecular genetic tool to investigate how a key regulatory protein controls gene expression in response to nitrogen starvation stress. Our understanding of these dynamic processes informs our approaches to the development of cancer therapies, to commercial biotechnology application and to control of human, plant and animal pathogens in which the infectious process is triggered by environmental stress. Read moreRead less
Simulating viral evolution and genetic complexity. This project has direct relevance to understanding the growth of viral infections, and therefore has possible practical applications in disease research and control. Examples of these are emerging diseases in humans such as those caused by HIV-1, SARS coronavirus and Dengue virus, which cause considerable human suffering throughout the world. A major part of current research into these diseases involves attempts to model the evolutionary geneti ....Simulating viral evolution and genetic complexity. This project has direct relevance to understanding the growth of viral infections, and therefore has possible practical applications in disease research and control. Examples of these are emerging diseases in humans such as those caused by HIV-1, SARS coronavirus and Dengue virus, which cause considerable human suffering throughout the world. A major part of current research into these diseases involves attempts to model the evolutionary genetics and dynamics of virus populations in order to understand how to control epidemics, develop vaccines and design drugs. The research program is designed to provide new computational modelling tools for this purpose, which may have wider applications as well.
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Molecular genetic analyses of trinucleotide repeat expansions. Several neuronal diseases like Huntington's disease, Frederick's ataxia and fragile X syndrome are caused by expansion of trinucleotide repeat sequences in the deoxyribonucleic acid (DNA). These diseases show progressive severity in subsequent generations. Here we use a simple plant model with a very similar DNA mutation to study the genetic basis of repeat expansions over several generations across populations. This proposal will im ....Molecular genetic analyses of trinucleotide repeat expansions. Several neuronal diseases like Huntington's disease, Frederick's ataxia and fragile X syndrome are caused by expansion of trinucleotide repeat sequences in the deoxyribonucleic acid (DNA). These diseases show progressive severity in subsequent generations. Here we use a simple plant model with a very similar DNA mutation to study the genetic basis of repeat expansions over several generations across populations. This proposal will improve our mechanistic understanding of genetic diseases in populations. In addition, this proposal is expected to lead to identification of potential targets and technologies that would be of interest to Australian industry.Read moreRead less
Knowledge to enhance Science Teaching and Learning: Pursuing scholarship through explicitly enacting expert science teachers' pedagogical content knowledge. This research will enhance understandings of science teaching and learning allowing science teachers to share their knowledge in meaningful ways. In teacher preparation this will be particularly valuable by 'fast-tracking' learning about teaching science and minimize the process of the next generation of teachers feeling as though they are r ....Knowledge to enhance Science Teaching and Learning: Pursuing scholarship through explicitly enacting expert science teachers' pedagogical content knowledge. This research will enhance understandings of science teaching and learning allowing science teachers to share their knowledge in meaningful ways. In teacher preparation this will be particularly valuable by 'fast-tracking' learning about teaching science and minimize the process of the next generation of teachers feeling as though they are rediscovering that which is already known by experienced teachers of science. In articulating science teachers' knowledge, enhanced valuing their knowledge and skills of practice will occur. Such outcomes will place understanding of science teaching and learning at the forefront of teacher professionalism and positively impact work on professional standards in teaching.Read moreRead less
Engaging science students' hearts and minds: Researching science teachers' professional learning in the development of contemporary understandings of scientific literacy. This project will develop, support and value the work of science teachers in developing students' scientific literacy and share the subsequent knowledge gains in the educational community to positively advance quality teaching and learning in school science. Improving science teaching and learning hinges on offering new ways of ....Engaging science students' hearts and minds: Researching science teachers' professional learning in the development of contemporary understandings of scientific literacy. This project will develop, support and value the work of science teachers in developing students' scientific literacy and share the subsequent knowledge gains in the educational community to positively advance quality teaching and learning in school science. Improving science teaching and learning hinges on offering new ways of responding to the problems inherent in teaching science in the 21st century. By supporting and encouraging the creative and innovative ideas, concepts and approaches to quality science teaching and learning embedded in teachers' professional learning the development of the critical knowledge for challenging the status-quo will be advanced.Read moreRead less
Research capacity-building: the development of Australian PhD programs in national and emerging global contexts. PhD programs in universities are the principal means by which new researchers are prepared for work in the knowledge economy. This project develops a comprehensive coded database of every PhD awarded in Australia since the first programs in the 1940s. It the will study fourteen different PhD programs that have developed during this period in four universities. The project focuses on ....Research capacity-building: the development of Australian PhD programs in national and emerging global contexts. PhD programs in universities are the principal means by which new researchers are prepared for work in the knowledge economy. This project develops a comprehensive coded database of every PhD awarded in Australia since the first programs in the 1940s. It the will study fourteen different PhD programs that have developed during this period in four universities. The project focuses on how these programs develop research capacity within disciplines and how these are related to the changing social, cultural and economic needs of Australia. The project will assist in planning future PhD programs and research capacity development.Read moreRead less
Australian doctoral graduates' publication, professional and community outcomes. The project produces benefits to government, universities, Deans and Directors of Graduate Studies and those with a scholarly interest in doctoral education. It identifies, quantifies and explains the relationship between PhD graduates' thesis outcomes (especially, publications) and their professional and community outcomes up to ten years from graduation. The findings will be disseminated as universities, governmen ....Australian doctoral graduates' publication, professional and community outcomes. The project produces benefits to government, universities, Deans and Directors of Graduate Studies and those with a scholarly interest in doctoral education. It identifies, quantifies and explains the relationship between PhD graduates' thesis outcomes (especially, publications) and their professional and community outcomes up to ten years from graduation. The findings will be disseminated as universities, government and academies debate the RQF outcomes and whether the quality and impact of doctorates be included in the next RQF. The findings enable universities to enhance policy and practice to ensure worthwhile outcomes from doctoral programs and graduates. The project advances scholarship about doctorates and research education.Read moreRead less
Individual, Institutional and Community 'Capacity Building' in a Cluster of Disadvantaged Schools and their Community. It is no longer ethically, socially or economically acceptable to have significant and growing proportions of the school population that are alienated, marginalised and excluded from a satisfying and rewarding educational experience. The national and community benefits for Australia expected from this research will be a better understanding of, and possibly alleviation of, the s ....Individual, Institutional and Community 'Capacity Building' in a Cluster of Disadvantaged Schools and their Community. It is no longer ethically, socially or economically acceptable to have significant and growing proportions of the school population that are alienated, marginalised and excluded from a satisfying and rewarding educational experience. The national and community benefits for Australia expected from this research will be a better understanding of, and possibly alleviation of, the structural educational impediments that operate on disadvantaged individuals, institutions and communities. It is in the national interest to have a society in which all its members, not just the privileged, gain lifelong benefit from a rewarding schooling experience.Read moreRead less
The influence of disciplinary cultures on approaches to undergraduate teaching and learning: extending higher education theory and practice. Improving the quality of teaching in higher education is an important priority for Australian universities. There has been rapid growth in the number of training programs for university teachers. This study will directly support these efforts. It will investigate the effectiveness of the diverse approaches to teaching and learning traditionally adopted with ....The influence of disciplinary cultures on approaches to undergraduate teaching and learning: extending higher education theory and practice. Improving the quality of teaching in higher education is an important priority for Australian universities. There has been rapid growth in the number of training programs for university teachers. This study will directly support these efforts. It will investigate the effectiveness of the diverse approaches to teaching and learning traditionally adopted within different fields of study?across the sciences, the arts, the humanities and the professions. The findings will be used to develop new training programs for university teachers that are tailored towards best practice in the particular areas of knowledge in which staff are teaching. Enhanced training of university teachers will lead to better teaching and better student outcomes.Read moreRead less