The Role And Underlying Mechanisms Of Constitutional Epigenetic Silencing In Cancer Predisposition
Funder
National Health and Medical Research Council
Funding Amount
$218,617.00
Summary
Familial and young onset bowel and uterine cancer are usually caused by the inheritance of spelling mistakes in the genetic code within a set of cancer-protection genes. Recently, some patients were identified with their gene switched off by paralysing chemicals instead. This study aims to identify additional cancer cases with gene paralysis, determine if this arises in the presence or absence of a genetic change in front of the gene, and how gene paralysis is transmitted to the next generation.
Australian Laureate Fellowships - Grant ID: FL200100068
Funder
Australian Research Council
Funding Amount
$3,328,974.00
Summary
Australian wild animals: environmental change and quantitative genomics. This project aims to determine the effects of changing environments on wild animal populations across Australia. By combining recent advances in genomic technology with a consortium of fourteen long-term studies of mammals, birds and reptiles, it aims to quantify the genetic basis of life-history variation and the potential for evolutionary adaptation in the wild. The project will generate a comprehensive understanding of t ....Australian wild animals: environmental change and quantitative genomics. This project aims to determine the effects of changing environments on wild animal populations across Australia. By combining recent advances in genomic technology with a consortium of fourteen long-term studies of mammals, birds and reptiles, it aims to quantify the genetic basis of life-history variation and the potential for evolutionary adaptation in the wild. The project will generate a comprehensive understanding of the genetic consequences of environmental change, population decline, inbreeding and disease in natural environments. The expected benefits include a coordinated network for long-term wild animal studies in Australia, advanced quantitative skills training, and knowledge transfer for wildlife management and conservation.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE210100549
Funder
Australian Research Council
Funding Amount
$417,328.00
Summary
Adaptive evolution and its demographic consequences today. This project aims to provide the first test of whether the rate of adaptative genetic evolution has changed in the recent decades, to quantify how much recent genetic evolution helps animal populations survive, and to increase the ability to study on-going genetic evolution in Australian wildlife. The project is of major significance as many species are currently threatened, or invading, due to rapid environmental changes, in particular ....Adaptive evolution and its demographic consequences today. This project aims to provide the first test of whether the rate of adaptative genetic evolution has changed in the recent decades, to quantify how much recent genetic evolution helps animal populations survive, and to increase the ability to study on-going genetic evolution in Australian wildlife. The project is of major significance as many species are currently threatened, or invading, due to rapid environmental changes, in particular climate change. The anticipated outcome of the project is to deliver new methods, establish a network of international and national collaborators and improve the ability to measure and to forecast how Australian animals adapt to rapidly changing environments.Read moreRead less
Special Research Initiatives - Grant ID: SR0354580
Funder
Australian Research Council
Funding Amount
$10,000.00
Summary
Sustainable Futures through Understanding Past Human Responses to Environmental Change. This Network brings together researchers within archaeology and environmental sciences to develop cross-disciplinary and internationally comparative approaches to understanding past human responses to rapid environmental change. Integration of skills and perspectives from the Humanities and Sciences will create a generation of scholars able to work across different theoretical frameworks to formulate credible ....Sustainable Futures through Understanding Past Human Responses to Environmental Change. This Network brings together researchers within archaeology and environmental sciences to develop cross-disciplinary and internationally comparative approaches to understanding past human responses to rapid environmental change. Integration of skills and perspectives from the Humanities and Sciences will create a generation of scholars able to work across different theoretical frameworks to formulate credible responses to the challenge of creating sustainable societies in a changing world. Through a greater understanding of past societies' reactions to rapid environmental change, the Network will build on existing leading edge research and create a more informed guide to a sustainable future.Read moreRead less
Indian Textile Technology as archaeological evidence for population movements in Early Southeast Asia. This project uses archaeological textiles to investigate population movements in the late prehistoric period of Southeast Asia. It involves collaborative links between researchers from the Institute of Archaeology in Vietnam, the Centre for Southeast Asian Prehistory in Ho Chi Minh City, the Fine Arts Department of Thailand and museums and archaeological institutions in South India. It not only ....Indian Textile Technology as archaeological evidence for population movements in Early Southeast Asia. This project uses archaeological textiles to investigate population movements in the late prehistoric period of Southeast Asia. It involves collaborative links between researchers from the Institute of Archaeology in Vietnam, the Centre for Southeast Asian Prehistory in Ho Chi Minh City, the Fine Arts Department of Thailand and museums and archaeological institutions in South India. It not only profiles Australian expertise in Southeast Asia but facilitates high levels of communication and the exchange of ideas. Read moreRead less
Navigating tipping points in complex dynamical systems. This project aims to use applied mathematics to investigate the onset of tipping points in dynamical systems. Working with clinicians and practicing engineers, the project aims to contribute to the development of new treatment regimes for dynamical diseases and develop improved management strategies for resource focussed engineering industries. This should provide significant benefit to many areas, including the personalised treatment of di ....Navigating tipping points in complex dynamical systems. This project aims to use applied mathematics to investigate the onset of tipping points in dynamical systems. Working with clinicians and practicing engineers, the project aims to contribute to the development of new treatment regimes for dynamical diseases and develop improved management strategies for resource focussed engineering industries. This should provide significant benefit to many areas, including the personalised treatment of disease.Read moreRead less
Crossing the Green Sea: maritime mobility, trans-oceanic interaction and remote island colonisation in the tropical Indian Ocean. Australia is an Indian Ocean nation. It is strategically and politically important to understand our Indian Ocean neighbours, including small island nations such as the Maldives and Seychelles. Researching their history is part of this process. Building a collaborative research capacity between Australian and other Indian Ocean scholars, publishing the results of rese ....Crossing the Green Sea: maritime mobility, trans-oceanic interaction and remote island colonisation in the tropical Indian Ocean. Australia is an Indian Ocean nation. It is strategically and politically important to understand our Indian Ocean neighbours, including small island nations such as the Maldives and Seychelles. Researching their history is part of this process. Building a collaborative research capacity between Australian and other Indian Ocean scholars, publishing the results of research, building them into educational curricula, and maintaining a pool of Indian Ocean scholarly expertise in Australia is a national and community benefit. In addition, research results on the history of human colonisation and human impact on vulnerable environments will be significant to Australia as an island nation.Read moreRead less
Tracking 3000 years of agricultural adaptation to the resource poor, climate sensitive and remote Solomon Islands using biomarkers and palaeoecology. Establishing research programs with Pacific neighbours benefits Australia's relations with Pacific Island countries generally. This project applies novel research methods to understanding human adaptations to long-term environmental and climatic fluctuations. It will address the National Research Priority goal of responding to climate variability b ....Tracking 3000 years of agricultural adaptation to the resource poor, climate sensitive and remote Solomon Islands using biomarkers and palaeoecology. Establishing research programs with Pacific neighbours benefits Australia's relations with Pacific Island countries generally. This project applies novel research methods to understanding human adaptations to long-term environmental and climatic fluctuations. It will address the National Research Priority goal of responding to climate variability by advancing our understanding of recent climate change in the Australia/Pacific region. It will show that Australian researchers can play a significant role in understanding the spread of humans across the Pacific, and the environmental adaptations required by populations in resource depleted environments. It will increase collaboration between research institutions focusing on the Australia/Pacific region.Read moreRead less
Persistence and transformation in Ancestral Oceanic Society: the archaeology of the first 1500 years in the Vanuatu archipelago. Supporting research programs with smaller Pacific Island neighbours fosters Australia's relationship with those countries generally. The project will contribute to regional capacity building in the areas of archaeology, heritage studies and management. This research will enhance understanding of the region's deep human past and the way it articulates historically with ....Persistence and transformation in Ancestral Oceanic Society: the archaeology of the first 1500 years in the Vanuatu archipelago. Supporting research programs with smaller Pacific Island neighbours fosters Australia's relationship with those countries generally. The project will contribute to regional capacity building in the areas of archaeology, heritage studies and management. This research will enhance understanding of the region's deep human past and the way it articulates historically with the rest of the world. It will advance Australia's understanding of its nearest neighbours as well as provide those neighbours with information that goes towards strengthening national identity. The proposed research has direct relevance to ongoing debates within Australian and World archaeology and related disciplines, and fosters international collaborative links. Read moreRead less
Northern Vanuatu as a Pacific Crossroads: The archaeology of discovery, interaction and the emergence of the ethnographic present. The project addresses the National Research Priority Goal of "Understanding our Region and the World". Supporting research programs with smaller Pacific Island neighbours such as Vanuatu fosters Australia's relationship with those countries generally. This research will strengthen our knowledge of the region's deep human past. It will advance Australia's understandin ....Northern Vanuatu as a Pacific Crossroads: The archaeology of discovery, interaction and the emergence of the ethnographic present. The project addresses the National Research Priority Goal of "Understanding our Region and the World". Supporting research programs with smaller Pacific Island neighbours such as Vanuatu fosters Australia's relationship with those countries generally. This research will strengthen our knowledge of the region's deep human past. It will advance Australia's understanding of its nearest neighbours as well as provide those neighbours with information they can use to shape their own views of their past and its relationship to their present. The proposed research has direct relevance to on-going debates within world archaeology and related disciplines.Read moreRead less