A multi-agent system for stakeholder management in off-site construction. This project aims to investigate a socio-technology model for stakeholders and informatics to improve off-site construction (OSC) productivity in infrastructure construction. A multi-agent system for OSC could drive down cost, but requires highly integrated collaboration among stakeholders. The project’s quantitative approaches include large-scale social network analysis, multi-agent consensus modelling and an optimisation ....A multi-agent system for stakeholder management in off-site construction. This project aims to investigate a socio-technology model for stakeholders and informatics to improve off-site construction (OSC) productivity in infrastructure construction. A multi-agent system for OSC could drive down cost, but requires highly integrated collaboration among stakeholders. The project’s quantitative approaches include large-scale social network analysis, multi-agent consensus modelling and an optimisation algorithm for collaborative planning. The project outcomes are expected to secure long-term economic benefits by enhancing performance in complex projects.Read moreRead less
Rethinking housing: network analysis for digital collaboration. This project aims to understand persistent housing sector supply problems through analysis of digital collaborative practices. This project expects to generate new knowledge for an emerging housing digital economy using interdisciplinary network theory and data visualisation techniques. The housing sector has long been criticised for shortcomings in affordability, efficiency, quality, social and environmental responsiveness and appr ....Rethinking housing: network analysis for digital collaboration. This project aims to understand persistent housing sector supply problems through analysis of digital collaborative practices. This project expects to generate new knowledge for an emerging housing digital economy using interdisciplinary network theory and data visualisation techniques. The housing sector has long been criticised for shortcomings in affordability, efficiency, quality, social and environmental responsiveness and appropriateness of offerings. Expected outcomes include enhanced housing supply professionals' capability, improved knowledge among public/private sector decision makers responsible for housing supply and development of new digital collaborative behavioural theoretical and practical frameworks for the sector.Read moreRead less
Efficient construction: analysis of integrated supply chains for innovative off site housing manufacturing. The Australian housing industry is failing to meet demand. Housing construction is too slow, as indicated by a 40 per cent increase in average construction time over the last fifteen years. Industry fragmentation is an oft-cited cause of construction inefficiency. A solution is offsite manufacturing. Australia lags other countries in adoption of off-site manufacturing. To achieve adoption ....Efficient construction: analysis of integrated supply chains for innovative off site housing manufacturing. The Australian housing industry is failing to meet demand. Housing construction is too slow, as indicated by a 40 per cent increase in average construction time over the last fifteen years. Industry fragmentation is an oft-cited cause of construction inefficiency. A solution is offsite manufacturing. Australia lags other countries in adoption of off-site manufacturing. To achieve adoption and diffusion, fragmentation needs to be addressed. This project aims to analyse the factors affecting supply chain integration to support innovative offsite manufacturing and develop a novel collaborative practice based implementation model.Read moreRead less
Small is beautiful: Did gene-rich regions of mammal chromosomes evolve from microchromosomes? Most birds and reptile genomes feature many tiny microchromosomes. These are not junk, as previously thought, but contain most of the genes. Mammals lack microchromosomes, but contain gene-rich regions with similar attributes. We suggest that microchromosomes originated by genome duplication, and evolved into the gene-rich regions of mammalian chromosomes. We will test this hypothesis by comparing seque ....Small is beautiful: Did gene-rich regions of mammal chromosomes evolve from microchromosomes? Most birds and reptile genomes feature many tiny microchromosomes. These are not junk, as previously thought, but contain most of the genes. Mammals lack microchromosomes, but contain gene-rich regions with similar attributes. We suggest that microchromosomes originated by genome duplication, and evolved into the gene-rich regions of mammalian chromosomes. We will test this hypothesis by comparing sequences and genes in microchromosomes of birds, reptiles and monotremes. This will clarify the origin and evolution of the ?microgenome?, establish its suitability as a model for vertebrate genome organisation, and demonstrate whether microchromosomes are the ancestors of the gene-rich regions of mammalian chromosomes.Read moreRead less
Road rules for traffic on DNA - gene regulation by encounters between transcribing RNA polymerases and DNA-bound proteins. This project addresses a widespread but poorly understood phenomenon in gene regulation. The work will support Australian industries by supplying new tools for manipulation of gene expression for industrial and medical applications and will provide unique opportunities for Australian students in this emerging field.
Constructing Building Integrity: Raising standards through professionalism. This project aims to investigate the role of professions in rebuilding trust in residential building construction in Australia. In the wake of expensive and life-threatening building defects, this project expects to generate new knowledge about the functioning of individual professionals, professionals employed in multi-profession organisations, and professionals’ interaction with their institutional environment. Expecte ....Constructing Building Integrity: Raising standards through professionalism. This project aims to investigate the role of professions in rebuilding trust in residential building construction in Australia. In the wake of expensive and life-threatening building defects, this project expects to generate new knowledge about the functioning of individual professionals, professionals employed in multi-profession organisations, and professionals’ interaction with their institutional environment. Expected outcomes include practical recommendations for improved professional standards, a rigorous building integrity system and a means for measuring change. Anticipated benefits include greater awareness by professions, trades and regulators of their role in in delivering the public goods of a trustworthy construction industry.Read moreRead less
Non-coding RNAs in mammalian reproduction. This project aims to investigate the role of non-coding RNAs in mammalian sex chromosome biology and reproduction. Non-protein coding RNAs are a major regulatory mechanism in eukaryotic genomes; they can bind other RNAs or chromatin modifying complexes. However, the evolutionary trajectory and function of non-coding RNAs in sex chromosome biology and sexual development is largely unknown. This project will study non-coding RNAs in Australian mammals to ....Non-coding RNAs in mammalian reproduction. This project aims to investigate the role of non-coding RNAs in mammalian sex chromosome biology and reproduction. Non-protein coding RNAs are a major regulatory mechanism in eukaryotic genomes; they can bind other RNAs or chromatin modifying complexes. However, the evolutionary trajectory and function of non-coding RNAs in sex chromosome biology and sexual development is largely unknown. This project will study non-coding RNAs in Australian mammals to try to answer fundamental questions about how non-coding RNAs function in mammalian sexual development.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0775503
Funder
Australian Research Council
Funding Amount
$255,000.00
Summary
Robotics for plant genomics: Increasing throughput in plant genetic analyses. Plant genomics has direct benefit to crop improvement, especially as focussed in the applicants' laboratories. Thus, the Australian agri-food sector will benefit substantially from the acceleration in plant functional genomics that will arise from the installation of the robotics equipment described in the current application, by both underpinning more applied research and also being used directly in crop improvement p ....Robotics for plant genomics: Increasing throughput in plant genetic analyses. Plant genomics has direct benefit to crop improvement, especially as focussed in the applicants' laboratories. Thus, the Australian agri-food sector will benefit substantially from the acceleration in plant functional genomics that will arise from the installation of the robotics equipment described in the current application, by both underpinning more applied research and also being used directly in crop improvement programs such as are based at the Waite Campus. The outputs will include crops with increased tolerance to biotic and abiotic stresses, a reduced dependence on chemical inputs such as fertilisers and improved food quality, with consequent benefits to the environment and human health and nutrition.Read moreRead less
Endosymbiotic DNA transfer. Interorganellar DNA movement is a major force in evolution. In higher organisms, the prokaryotic ancestors of mitochondria and chloroplasts donated many genes to the nucleus. Plants have unique potential in studies of the mechanisms that have driven genome evolution. We established experimentally that DNA moves from the chloroplast to the nucleus at high frequency and this provided us with a world lead in this scientifically new area. The relocated genes contribute to ....Endosymbiotic DNA transfer. Interorganellar DNA movement is a major force in evolution. In higher organisms, the prokaryotic ancestors of mitochondria and chloroplasts donated many genes to the nucleus. Plants have unique potential in studies of the mechanisms that have driven genome evolution. We established experimentally that DNA moves from the chloroplast to the nucleus at high frequency and this provided us with a world lead in this scientifically new area. The relocated genes contribute to the number and diversity of genes and gene function. Genetically manipulated (GM) crops use the chloroplast compartment to make high levels of protein, necessitating a full understanding of how transgenes behave within the cellular and the external environment.Read moreRead less
Solving the Mysteries of Monotreme Chromosomes. The peculiar chromosomes of Australia's platypus and echidna have been debated for more than 30 years. Classical cytology cannot resolve the puzzling sex chromosome system, or to sort out the bizarre translocation chain (unique in vertebrates) and deduce how it segregates to make viable zyotes. I will microdissect individual chromosomes, and use DNA ?paints? from them (and gene probes isolated by them) to detect homologies between unpaired chromoso ....Solving the Mysteries of Monotreme Chromosomes. The peculiar chromosomes of Australia's platypus and echidna have been debated for more than 30 years. Classical cytology cannot resolve the puzzling sex chromosome system, or to sort out the bizarre translocation chain (unique in vertebrates) and deduce how it segregates to make viable zyotes. I will microdissect individual chromosomes, and use DNA ?paints? from them (and gene probes isolated by them) to detect homologies between unpaired chromosomes at mitosis, meiosis and in sperm. I will use immunohistochemistry to clarify chromosome pairing and recombination at meiosis. This will answer some important general questions about chromosome behaviour and sex chromosome evolution.
Read moreRead less