Gene-environment Interaction In Healthy Brain Ageing And Age Related Neurodegeneration
Funder
National Health and Medical Research Council
Funding Amount
$2,162,805.00
Summary
Healthy ageing is characterised by low level of disability, high cognitive and functional capacity, and an active engagement in life. The most important ingredient of healthy ageing is a healthy brain, bereft of age-related diseases and dysfunction. Brain ageing and brain diseases are determined by multiple genetic factors that interact with environmental influences. The genes are multiple, the majority of which have a small influence. This study is an attempt to identify some of these genes and ....Healthy ageing is characterised by low level of disability, high cognitive and functional capacity, and an active engagement in life. The most important ingredient of healthy ageing is a healthy brain, bereft of age-related diseases and dysfunction. Brain ageing and brain diseases are determined by multiple genetic factors that interact with environmental influences. The genes are multiple, the majority of which have a small influence. This study is an attempt to identify some of these genes and investigate their interactions with environmental factors. It will use a unique resource, the NHMRC Australian Twin Registry (ATR) to identify elderly twins, and will also include the siblings of these twins so as to increase the ability to identify the important factors. The participants, who are listed on the ATR and recruited from NSW, Queensland and Victoria, will receive detailed neurological, psychiatric and cognitive assessments, and will undergo brain MRI scans. Their blood samples will be used to measure key chemicals that may affect brain ageing and to extract DNA for genetic tests. They will be followed-up every two years thereafter, and changes in their brain structure and cognitive functioning will be examined. Available statistical models will be used to examine gene-environment interactions and specific genes will be explored for their contribution to the additive genetic effects. This study will yield an important resource for national and international collaborations and has the potential to discover new genes.Read moreRead less
Prevention And Management Of Mental Disorders In Older Australians
Funder
National Health and Medical Research Council
Funding Amount
$2,486,509.00
Summary
Dementia, mild cognitive impairment and depression are the major neuropsychiatric problems that Australia’s ageing population will face in the next 50 years. With the rapid advances in neuroscience, we need a cohort of young researchers who can translate this knowledge into better health outcomes for older Australians. The Brain and Ageing Program (B and AP) at the University of New South Wales (UNSW) has identified potential future leaders who will develop key research themes to improve the men ....Dementia, mild cognitive impairment and depression are the major neuropsychiatric problems that Australia’s ageing population will face in the next 50 years. With the rapid advances in neuroscience, we need a cohort of young researchers who can translate this knowledge into better health outcomes for older Australians. The Brain and Ageing Program (B and AP) at the University of New South Wales (UNSW) has identified potential future leaders who will develop key research themes to improve the mental health of older Australians. This grant will enable them to take on this challenge.Read moreRead less
Plasma protein profiles in normal brain ageing and early stages of dementia. Brain changes related to ageing and dementia are associated with altered proteins that can be detected in the blood. This project will examine blood samples from a number of well-characterised ageing cohorts to discover proteins that may serve as potential markers of brain ageing and the early stages of dementia.
Prefrontal and medial temporal lobe cortices' interactions to episodic long-term memory. Current models of episodic memory in humans are incomplete. They mostly consider only one of the two brain systems known to be critical to this cognitive ability. This project will propose the first comprehensive model of episodic memory and, in doing so, will advance our knowledge of human memory systems and will maintain Australian research competitiveness in a domain that is fast evolving. This research c ....Prefrontal and medial temporal lobe cortices' interactions to episodic long-term memory. Current models of episodic memory in humans are incomplete. They mostly consider only one of the two brain systems known to be critical to this cognitive ability. This project will propose the first comprehensive model of episodic memory and, in doing so, will advance our knowledge of human memory systems and will maintain Australian research competitiveness in a domain that is fast evolving. This research contributes to ageing well, ageing productively. Because memory deficits are becoming increasingly common in our ageing population and may represent a sign of dementia, accurate evaluation of episodic memory integrity is essential.Read moreRead less
An anti-senescence nanoplatform and its underlying mechanism. The project will bring together complementary expertise and skills by combining biomaterials, cell and molecular biology, and engineering, to develop a novel nano-biomaterial platform for anti-senescence and gain an in-depth understanding of its underlying mechanisms. The underlying mechanisms of senescence remain elusive and bone substitutes with anti-senescence property have not been explored and becoming a growing field of interest ....An anti-senescence nanoplatform and its underlying mechanism. The project will bring together complementary expertise and skills by combining biomaterials, cell and molecular biology, and engineering, to develop a novel nano-biomaterial platform for anti-senescence and gain an in-depth understanding of its underlying mechanisms. The underlying mechanisms of senescence remain elusive and bone substitutes with anti-senescence property have not been explored and becoming a growing field of interest in bone regeneration. The project will develop a well-defined and efficient nanomaterial platform with optimal combination of nano-surface features and chemistry for cell rejuvenation, and it will give unprecedented depth of interdisciplinary understanding of senescence rejuvenation mechanisms.Read moreRead less