The glomerulus is the filtering component of the kidney. In many diseases, it can be the target of an inappropriate inflammatory response. As part of this response, white blood cells accumulate in the glomerulus where they cause damage. In this project, we make use of special microscopes to examine the glomerulus during an inflammatory response, with the aim of understanding the actions of leukocytes present in glomeruli and how they cause inflammation and damage the glomerulus.
Inflammation of the kidneys is an important, yet poorly understood cause of kidney disease in Australia. This project will define the role of some of the immune cells, called Th17, that usually act to protect us from infection, but can turn rouge and may cause kidney damage.
Monocytes On Patrol – Key Mediators Of Renal Injury In Glomerulonephritis
Funder
National Health and Medical Research Council
Funding Amount
$772,888.00
Summary
The glomerulus is the filtering component of the kidney. In many diseases, it can be the target of an inappropriate inflammatory response. As part of this response, white blood cells accumulate in the glomerulus where they cause damage. In this project, we make use of special microscopes to examine the glomerulus during an inflammatory response, with the aim of understanding the actions of white blood cells present in glomeruli and how they cause inflammation and damage the glomerulus.
TLR9 AGGRAVATES GLOMERULONEPHRITIS AND KIDNEY INJURY IN RENAL VASCULITIS
Funder
National Health and Medical Research Council
Funding Amount
$349,336.00
Summary
Renal failure is a significant cause of morbidity and mortality in Australia. Anti-neutrophil cytoplasmic antibody (ANCA) vasculitis associated glomerulonephritis (GN) is a significant cause of renal failure. The molecular mechanisms underlying ANCA vasculitis are poorly understood, while treatments are associated with considerable morbidity and mortality. This grant aims to explore key molecular events involved in the disease pathogenesis to facilitate the use of safer more targeted therapies.
Human Podocyte Depletion, Glomerular Hypertrophy And Glomerulosclerosis
Funder
National Health and Medical Research Council
Funding Amount
$601,490.00
Summary
Many kidney diseases commence with injury to glomeruli (kidney filters) which leads to glomerular scarring and loss. There is strong evidence from animal studies that a specific glomerular cell type (the podocyte) is central to this process of glomerular injury. In this study, we will analyse the relationships between podocyte depletion and glomerular scarring in human kidneys from 5 racial groups (white and African Americans, white and Aboriginal Australians, Senegalese Africans).
The Role Of Presenilin In Metal Homeostasis And Alzheimers Disease
Funder
National Health and Medical Research Council
Funding Amount
$86,335.00
Summary
Presenilin, a protein involved in Alzheimer’s disease (AD), may regulate copper and zinc levels. Copper and zinc are essential nutrients however a deficiency or excess can cause disease. Promising metal-altering AD drugs, are in various stages of clinical trial. I aim to characterize the interaction of Presenilin and metals using both mouse and cultured human cell models that are deficient in Presenilin. Understanding this interaction should lead to better drug design and treatment of AD.
Understanding How Bcl-2 Proteins Form The Apoptotic Pores That Kill Cells
Funder
National Health and Medical Research Council
Funding Amount
$893,614.00
Summary
Programmed cell death termed apoptosis is a process our bodies use to remove cells that are a threat to our health, e.g. cancer cells. The proteins that regulate cell death are attractive targets for therapeutics that have become resistant to this defence mechanism. This study will reveal how proteins from the Bcl-2 family regulate cell death at the molecular level. Understanding this process will inform the development of drugs aimed at regulating cell death in cancer and other diseases.
What Is The Molecular Mechanism Underlying Cell Death By Necroptosis?
Funder
National Health and Medical Research Council
Funding Amount
$653,742.00
Summary
Recently, we and others have demonstrated that part of the MLKL protein is able to kill cells. This process is known to cause a number of pathologies, including those arising from stroke. Blocking this type of cell death has thus emerged as an attractive therapeutic strategy. However, precisely how MLKL kills cells remains unclear and controversial. In this project, we will resolve these controversies with the goal of an increased fundamental understanding to aid drug discovery.
The Effective Treatment of Hot Dip Galvanizing Effluent Streams. Hot Dip galvanizing effluent represents a significant environmental hazard. This wastewater is currently trucked offsite and treated by contractors to precipitate a heavy metal sludge that is disposed of through landfill. Industrial Galvanisers, as the largest hot dip galvanizing company within Australia, are keen to eliminate this hazard. We will consider the use of an innovative membrane based process for this purpose; to recover ....The Effective Treatment of Hot Dip Galvanizing Effluent Streams. Hot Dip galvanizing effluent represents a significant environmental hazard. This wastewater is currently trucked offsite and treated by contractors to precipitate a heavy metal sludge that is disposed of through landfill. Industrial Galvanisers, as the largest hot dip galvanizing company within Australia, are keen to eliminate this hazard. We will consider the use of an innovative membrane based process for this purpose; to recover valuable zinc and iron compounds from the effluent and allow the water to be re-utilised. If successful, this project will lead to a pilot plant wastewater treatment plant being constructed at an Industrial Galvanizers site.Read moreRead less
The Treatment Of Galvanizing Wastewater: Delivering An Environmentally And Economically Sustainable Approach. This project will investigate a process to treat wastewater from industrial galvanizing sites around Australia. When implemented, the process will substantially reduce the consumption of acid and fresh water at these sites. Further, the process will recover the zinc content of the wastewater in a saleable form and can also generate ferric chloride for sale as a water treatment chemical. ....The Treatment Of Galvanizing Wastewater: Delivering An Environmentally And Economically Sustainable Approach. This project will investigate a process to treat wastewater from industrial galvanizing sites around Australia. When implemented, the process will substantially reduce the consumption of acid and fresh water at these sites. Further, the process will recover the zinc content of the wastewater in a saleable form and can also generate ferric chloride for sale as a water treatment chemical. The quantity of heavy metals disposed to landfill will also be dramatically reduced. Scientific knowledge of multicomponent liquid-liquid equilibria will be of value to a wider range of solvent extraction processes including zinc and copper metal refining.Read moreRead less