BIRTHPLACE IN AUSTRALIA: A PROSPECTIVE COHORT STUDY
Funder
National Health and Medical Research Council
Funding Amount
$834,782.00
Summary
There is considerable debate about the safety of maternity services in Australia. This has been increased by the National Maternity Services Review and the National Maternity Plan with particular concerns about homebirth and birth centres. This study aims to examine the safety of place of birth for healthy women. This national study will include women across the country. It is the first time such a study has been undertaken in Australia and will provide much needed evidence as to the safety of p ....There is considerable debate about the safety of maternity services in Australia. This has been increased by the National Maternity Services Review and the National Maternity Plan with particular concerns about homebirth and birth centres. This study aims to examine the safety of place of birth for healthy women. This national study will include women across the country. It is the first time such a study has been undertaken in Australia and will provide much needed evidence as to the safety of place of birth.Read moreRead less
Targeting Skeletal MTORC1 As A Novel Approach For The Treatment Of Diet-induced Insulin Resistance
Funder
National Health and Medical Research Council
Funding Amount
$586,979.00
Summary
Diet-induced insulin resistance is a pathology that underlies type 2 diabetes. Elucidating the pathways and tissues that contribute to this condition is crucial for drug development. The skeleton has emerged as a critical insulin target tissue. We provide evidence that suppression of mTORC1, a complex over-activated by nutrients, in bone cells improves insulin sensitivity. In this study, we will determine if blocking mTORC1 function in bone cells can treat diet-induced insulin resistance.
The Gudaga Study is a unique study of Aboriginal children in an urban environment on the eastern seaboard of Australia. Children were recruited at birth and have been followed up at 6-monthly intervals to age 5 years. This research aims to describe the health, early learning and service context of these urban Aboriginal children from 5 to 9 years. Detailed longitudinal data on Aboriginal children's early life experiences have not previously been collected in an urban setting.
Quantifying The Burden Of Atrial Fibrillation: Impact Of Existing And New Treatments And The Potential For Prevention
Funder
National Health and Medical Research Council
Funding Amount
$398,395.00
Summary
Atrial fibrillation (AF) causes considerable morbidity and burden to the Australian economy. We will quantify the prevalent burden and costs of hospitalised AF, ascertain the risk of major events associated with AF and the impact of existing treatments, and determine the population-attributable risk for AF due to emerging risk factors. Our data will inform clinicians and health policy makers regarding the most effective allocation of expensive health care resources to minimise the burden of AF.
Understanding Health Service System Needs For People With Intellectual Disability
Funder
National Health and Medical Research Council
Funding Amount
$1,216,389.00
Summary
The health of people with intellectual disability (ID) is one of the poorest of any group in Australia. People with ID experience higher rates of ill health, poor access to responsive health services and premature death. Our research will develop the first comprehensive profile of health, health service and medicines use and costs for people with ID, and will examine the impact of the National Disability Insurance Scheme (NDIS) on these metrics.
Pharmaceutical Opioids For Chronic Non-cancer Pain: Evaluating Health Outcomes And Economic Impact Over Five Years
Funder
National Health and Medical Research Council
Funding Amount
$775,922.00
Summary
Chronic non-cancer pain (CNCP) is a major contributor to disability. Increased opioid prescribing for CNCP has produced concern about dependence and overdose in the absence on data on its long-term effectiveness. Novel statistical methods will test causal relationships over 5 years between treatment, outcomes, and costs on 1,514 CNCP patients prescribed opioids. We will answer critical questions on 5-year outcomes, and whether, and for whom, opioids and other clinical interventions reduce costs.
Improving Efficiency Of Surveillance Colonoscopy For Colorectal Cancer Prevention
Funder
National Health and Medical Research Council
Funding Amount
$643,123.00
Summary
Greater awareness of bowel cancer screening has led to increased demand and waiting times for colonoscopy. National guidelines recognise the need for research to identify the best use of colonoscopy to ensure health funds are directed where they are needed. This study aims to identify how often colonoscopy is required for the best patient outcomes. Data about cancer and death will be linked to hospital and laboratory data to identify which patients need more or less surveillance colonoscopies.
A Novel Portable System For Day And Night Closed Loop Automated Insulin Delivery In The Patient With Type 1 Diabetes
Funder
National Health and Medical Research Council
Funding Amount
$251,133.00
Summary
For patients with Type 1 Diabetes, improved glucose control has been shown to reduce the development of diabetes complications. Although advances have been made in therapy, most people with diabetes do not achieve optimal treatment targets and the burden of care is high. Technologies now exist that allow the development of automatic insulin therapy and the artificial pancreas. These experiments will test a novel portable system that represents a significant step advancing toward this goal.
Epilepsy is often poorly controlled by medication and dietary measures can be taken that reduce occurrence of epileptic seizures. Glucose control is impacted by diet and also mutations in the genes that move glucose around the body are known to cause epilepsy. Here we will be studying how the genetic and dietary control of glucose levels impacts brain function to increase seizures and to potentially reveal novel therapies.
Carnitine Acetyltransferase (CrAT) Regulates Appetite And Body Weight Through The Melanocortin System
Funder
National Health and Medical Research Council
Funding Amount
$547,087.00
Summary
Carnitine metabolism in peripheral tissues, such as muscle, maintains appropriate cellular metabolism and function. Little is known about carnitine metabolism in specific populations of brain cells regulate food intake and appetite. This project aims to understand how carnitine metabolism affect brain cells that regulate food intake and body weight.