Novel Therapy For Enhancing Organ Maturation In Pre-term Babies
Funder
National Health and Medical Research Council
Funding Amount
$694,323.00
Summary
This project is developing a factor to enhance organ maturation and repair that may provide a new therapy for premature babies and fetuses with birth defects. This exciting new finding allows for the development of treatments of underdeveloped organs, in particular the lungs of premature and growth restricted babies. We are also trialing this factor in unborn babies with defects to the kidneys and lungs of which there is currently no cure.
Development Of A Novel MicroRNA Mimic For Cancer Treatment
Funder
National Health and Medical Research Council
Funding Amount
$534,179.00
Summary
Liver cancer is a major health burden globally, with a very poor prognosis. New treatments are urgently needed. We have developed proof-of-concept data showing that a tiny RNA, called a microRNA, is a powerful inhibitor of liver cancer growth. We will use this grant application to further develop the microRNA with novel chemistry so that it can be readily translated into early phase clinical trials in the near future.
Development Of An Effective Therapy For Cheyne-Stokes Breathing In Heart Failure.
Funder
National Health and Medical Research Council
Funding Amount
$604,030.00
Summary
During sleep, patients with heart failure often exhibit a cyclic pattern of breathing in which a period of regular breathing alternates with a period when breathing ceases. This breathing pattern is associated with increased mortality and reduced quality of life but to date no effective treatment for it exists. We have developed a method to calculate an exact level of carbon dioxide to stabilise breathing in each individual, offering the prospect of a better night’s sleep and a longer life.