The Future In Our Hands: Screening For Preclinical Alzheimer's Disease By Analysing Hand Movements
Funder
National Health and Medical Research Council
Funding Amount
$899,782.00
Summary
Alzheimer's disease (AD) starts damaging the brain 10-20 years before memory problems begin. By the time of diagnosis, it is hard to treat because the damage is so severe. We need a way to detect AD much earlier. We will develop a simple new computer test to detect early signs of AD by recording and analysing hand movements. Then people can start prevention earlier and scientists can research better treatments to improve people's quality of life and reduce the number of people with dementia.
Molecular tools for understanding, predicting and managing flowering and reproductive development in Brassica oleracea. This project integrates basic research with application to a significant horticultural industry, building on Australia's position as a leader in world research on molecular and genetic regulation of flowering. The project will strengthen Australia's research reputation in this field, provide new tools for cultivar screening in and management of B. oleracea seed crops. The proj ....Molecular tools for understanding, predicting and managing flowering and reproductive development in Brassica oleracea. This project integrates basic research with application to a significant horticultural industry, building on Australia's position as a leader in world research on molecular and genetic regulation of flowering. The project will strengthen Australia's research reputation in this field, provide new tools for cultivar screening in and management of B. oleracea seed crops. The project will deliver training for 3 PhD students at the interface between basic and applied research. A shortage of skilled scientists with ability to link understanding of plant development at the molecular/genetic level with improved crop management practices has been identified by the horticultural sector as a major challenge. Read moreRead less
Molecular pathways controlling light-regulated development in legumes. Legumes are widely grown as forage and grain crops and make a substantial contribution to the Australian economy. Light is an important determinant of plant architecture and productivity and we need to know more about how development is regulated by light in this important plant group. The natural light environment faced by plants is complex and varies with crop density, season and time of day. Understanding the interaction o ....Molecular pathways controlling light-regulated development in legumes. Legumes are widely grown as forage and grain crops and make a substantial contribution to the Australian economy. Light is an important determinant of plant architecture and productivity and we need to know more about how development is regulated by light in this important plant group. The natural light environment faced by plants is complex and varies with crop density, season and time of day. Understanding the interaction of photoreceptors and plant hormones in the control of growth is vital for manipulating crops to meet changing agronomic requirements. Training of students in state-of-the art techniques and the generation of new germplasm for use by other researchers and plant breeders will be other significant outcomes of the project.Read moreRead less
Cellular mechanisms that protect against copper-bound beta-amyloid. This project will investigate some of the brain’s own mechanisms for protecting itself against Alzheimer’s disease. Understanding these mechanisms will be important for developing future therapeutic strategies for treating Alzheimer’s disease.
The role of phytotoxins in ray blight disease of pyrethrum and significance of toxin tolerance to disease resistance. Ray blight disease, caused by Phoma ligulicola, is the greatest threat to the Australian pyrethrum industry causing $2.0M in annual losses. We aim to clarify the pathology of P.ligulicola in pyrethrum, focussing on the role of fungal toxins during infection. Toxin importance in disease will be determined through histology and induction of toxin- pathogen mutants. Toxins will be ....The role of phytotoxins in ray blight disease of pyrethrum and significance of toxin tolerance to disease resistance. Ray blight disease, caused by Phoma ligulicola, is the greatest threat to the Australian pyrethrum industry causing $2.0M in annual losses. We aim to clarify the pathology of P.ligulicola in pyrethrum, focussing on the role of fungal toxins during infection. Toxin importance in disease will be determined through histology and induction of toxin- pathogen mutants. Toxins will be characterised and used in tissue culture to select obtain toxin tolerant pyrethrum clones that will be evaluated for agronomic performance and disease resistance. Successful development of resistant clones will decrease production costs, minimise risk of fungicide resistance development and reduce environmental pollution.Read moreRead less
Ion transporters regulating plant adaptive responses to salinity and the modes of their control by compatible solutes in plant cells. Plants respond to saline conditions by a significant elevation in the level of compatible solutes in the cytosol. It appears that these solutes are not directly involved in conventional osmoprotection, but instead have a regulatory role in cell metabolism. This project will apply a range of state-of-the-art biophysical and molecular techniques to investigate the m ....Ion transporters regulating plant adaptive responses to salinity and the modes of their control by compatible solutes in plant cells. Plants respond to saline conditions by a significant elevation in the level of compatible solutes in the cytosol. It appears that these solutes are not directly involved in conventional osmoprotection, but instead have a regulatory role in cell metabolism. This project will apply a range of state-of-the-art biophysical and molecular techniques to investigate the modes of control exercised by compatible solutes over the activity of major plasma membrane transporters involved in plant adaptive responses to salinity. The work will substantially advance our understanding of salt tolerance and will provide a sound basis for genetic engineering of salt tolerant crops.Read moreRead less
Visualising neuron-glia interactions in the injured central nervous system. The adult brain and spinal cord recovery poorly from injury. Attempts to overcome this problem include methods to promote the intrinsic regenerative capacity of injured neurons, and modulating the inhibitory extracellular environment to become permissive to regeneration. The goal of this project is to investigate an endogenous regenerative mechanism in the injured brain. This project will use the latest, cutting-edge mic ....Visualising neuron-glia interactions in the injured central nervous system. The adult brain and spinal cord recovery poorly from injury. Attempts to overcome this problem include methods to promote the intrinsic regenerative capacity of injured neurons, and modulating the inhibitory extracellular environment to become permissive to regeneration. The goal of this project is to investigate an endogenous regenerative mechanism in the injured brain. This project will use the latest, cutting-edge microscopy techniques to visualise whether the endogenous astrocyte protein metallothionein can promote regeneration in the injured nervous system of living zebrafish. The successful outcomes of this project will provide significant insight into understanding how the brain responds to injury.Read moreRead less
The Role Of Excitotoxicity In Mediating Distal Axonal Degneration In ALS
Funder
National Health and Medical Research Council
Funding Amount
$392,952.00
Summary
Amyotrophic lateral sclerosis (ALS), the major cause of motor neuron disease, is a devastating diseasse for which there is no cure. There have been significant advances in understanding the pathology of ALS yet we still don’t know what causes the dying back of spinal motor neurons. We have new evidence that suggests that ALS may, in part, be caused by excitotoxcity - or over stimulation - of neurons in the spinal cord. We will follow this lead using a range of cutting edge experimental models.
Modelling Food Expenditure, Analysing Nutrient Security, Measuring Hunger and Calculating Purchasing Power Parity: Methodological Advances with Policy Applications. The analysis of consumption changes in selected Asian countries will throw light on Australia's trade potential, especially with one of the fastest growing countries.
More informed debate on the role of trade and aid in reducing hunger and poverty.Following the 2000 Millenium summit and the step up of Australian developmental aid, ....Modelling Food Expenditure, Analysing Nutrient Security, Measuring Hunger and Calculating Purchasing Power Parity: Methodological Advances with Policy Applications. The analysis of consumption changes in selected Asian countries will throw light on Australia's trade potential, especially with one of the fastest growing countries.
More informed debate on the role of trade and aid in reducing hunger and poverty.Following the 2000 Millenium summit and the step up of Australian developmental aid, the subject has returned to the centre stage in policy discussions.
The systematic use of unit value information available elsewhere, but currently lacking in ABS data, will help the latter in improving its HES.
Contribute to "understanding our region and the world"(Key Priority Goal in Research Priority 4 of ARC).
Provide data sets for use in Australian RHD dissertations .
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Linkage Infrastructure, Equipment And Facilities - Grant ID: LE120100006
Funder
Australian Research Council
Funding Amount
$600,000.00
Summary
An adaptable and dedicated linear accelerator for medical radiation research. Leading radiation scientists developing innovative methods and devices for treating cancer patients will collaborate in future research using this highly adaptable linear accelerator for medical radiation research. Innovations in tumour targeting, better patient safety, new medical devices and improved cancer outcomes are expected.