Role Of IGF Binding Protein-3 (IGFBP-3) And IGFBP-5 As Modulators Of Nuclear Hormone Signalling
Funder
National Health and Medical Research Council
Funding Amount
$465,750.00
Summary
The insulin-like growth factors are small proteins involved in the growth of most tissues. Their actions are regulated by binding to larger proteins (known as IGFBPs) in the bloodstream and outside the cell. However, some IGFBPs are also found inside cells, where they seem to carry out other functions. We believe that two of these binding proteins, IGFBP-3 and IGFBP-5, change the way cells respond to vitamin A and vitamin D. These two vitamins are important in cell growth and in the way certain ....The insulin-like growth factors are small proteins involved in the growth of most tissues. Their actions are regulated by binding to larger proteins (known as IGFBPs) in the bloodstream and outside the cell. However, some IGFBPs are also found inside cells, where they seem to carry out other functions. We believe that two of these binding proteins, IGFBP-3 and IGFBP-5, change the way cells respond to vitamin A and vitamin D. These two vitamins are important in cell growth and in the way certain cells perform specialised functions. In test-tube experiments, IGFBP-3 and IGFBP-5 interact directly with the receptors that regulate the effects of these hormones. If the same thing happens inside the cell, IGFBP-3 and IGFBP-5 could change the way these receptors respond to signals from outside the cell. We will investigate what effect these IGFBPs have in living cells and in whole animals and how this may relate to human disease. If we are able to understand how IGFBP-3 and IGFBP-5 affect the way cells respond to vitamin A and D, then we may be able to develop new ways to treat certain human diseases.Read moreRead less
Most eye diseases have a genetic contribution, whether rare disorders affecting children such as retinoblastoma or congenital cataracts through to common disorders of older people such as myopia, age-related macular degeneration or glaucoma. We will continue our successful research to find genes that cause these diseases and use this to improve patient care and prevent blindness. We will work out how families can use this genetic information to participate in trials to develop new treatments.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE200100003
Funder
Australian Research Council
Funding Amount
$400,000.00
Summary
3D Nanofabrication and Nanocharacterisation facility. This project aims to establish a revolutionary nanoscale fabrication and characterisation facility in Australia. The facility is an angle-based nanoscale etching system with integrated chemical analysis capabilities and will be the first instrument of its kind in Australia. The facility will enable unprecedented fabrication and characterisation of 3D nanostructures and new device geometries from semiconductors, oxides and metals that underpin ....3D Nanofabrication and Nanocharacterisation facility. This project aims to establish a revolutionary nanoscale fabrication and characterisation facility in Australia. The facility is an angle-based nanoscale etching system with integrated chemical analysis capabilities and will be the first instrument of its kind in Australia. The facility will enable unprecedented fabrication and characterisation of 3D nanostructures and new device geometries from semiconductors, oxides and metals that underpin modern nanoelectronics for innovative energy, nano-optical and quantum device applications. This unique equipment will facilitate breakthrough discoveries in nanomaterials, and foster collaborations amongst Australian researchers to accelerate industry in advanced nanodevice technologies.Read moreRead less
ARC Centre of Excellence in Convergent Bio-Nano Science and Technology. The CoE in Convergent Bio-Nano Science &Technology comprises a multi-disciplinary team focused on research aiming to understand and control the interface of materials with biological systems. The Centre will exploit knowledge of the bio-nano interface to design materials that transport and deliver vaccines, drugs and gene therapy agents, and to design new diagnostic agents and devices. Nanomedicines are on the cusp of revol ....ARC Centre of Excellence in Convergent Bio-Nano Science and Technology. The CoE in Convergent Bio-Nano Science &Technology comprises a multi-disciplinary team focused on research aiming to understand and control the interface of materials with biological systems. The Centre will exploit knowledge of the bio-nano interface to design materials that transport and deliver vaccines, drugs and gene therapy agents, and to design new diagnostic agents and devices. Nanomedicines are on the cusp of revolutionizing diagnosis and therapy in many diseases. The CoE will be the focus of bio-nano research activity in Australia, uniting universities, research agencies, institutes and companies. The expected outcomes are better diagnostic and therapeutic tools designed via an enhanced understanding of the bio-nano-interface.Read moreRead less
Improving Sexual Health In Men With Prostate Cancer: Randomised Controlled Trial Of Exercise And Psychosexual Therapies
Funder
National Health and Medical Research Council
Funding Amount
$583,416.00
Summary
Sexual dysfunction is one of the most common and distressing side effects of prostate cancer. Despite being a critical survivorship care issue, there is a clear gap in knowledge surrounding the optimal treatment of sexual dysfunction in men with prostate cancer. This project examines whether exercise aids in the management of sexual dysfunction and explores if an integrated treatment model incorporating pharmacological, exercise and psychosexual therapies maximises improvement in sexual health.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0668246
Funder
Australian Research Council
Funding Amount
$400,000.00
Summary
Advanced Cell Labelling and Imaging Facility. Understanding the genetic regulation of cellular processes such as migration, differentiation and growth is an important frontier technology with significant biomedical potential. The Australian community is facing an increasing need to provide solutions for a variety of human diseases and disorders, including birth defects, nervous system injury and stroke, and ageing-related conditions. The proposed facility will allow researchers to test in vivo g ....Advanced Cell Labelling and Imaging Facility. Understanding the genetic regulation of cellular processes such as migration, differentiation and growth is an important frontier technology with significant biomedical potential. The Australian community is facing an increasing need to provide solutions for a variety of human diseases and disorders, including birth defects, nervous system injury and stroke, and ageing-related conditions. The proposed facility will allow researchers to test in vivo gene/pharmaceutical therapies as well as to better understand the genetic regulation of normal cellular processes. Read moreRead less
Indoor Photovoltaics Enabled by Wide-Bandgap Perovskite Quantum Dots. This project aims to develop a high-efficiency indoor photovoltaic (PV) technology to provide reliable low-cost power in the multi-billion dollar “Internet of Things” (IoT) market. There are currently no devices that meet the requirements for maximum operating efficiency under indoor illumination. We propose to solve this problem by fabricating PV cells using colloidal perovskite quantum dots that offer class-leading stability ....Indoor Photovoltaics Enabled by Wide-Bandgap Perovskite Quantum Dots. This project aims to develop a high-efficiency indoor photovoltaic (PV) technology to provide reliable low-cost power in the multi-billion dollar “Internet of Things” (IoT) market. There are currently no devices that meet the requirements for maximum operating efficiency under indoor illumination. We propose to solve this problem by fabricating PV cells using colloidal perovskite quantum dots that offer class-leading stability and band gap tunability across the required range, enabled by quantum confinement. The outcome is the development of integrated self-powered IoT devices potentially impacting Advanced Manufacturing growth in Energy, Cyber Security, Food and Agribusiness, as all of these will ultimately rely on networked smart devices.Read moreRead less
Social cohesion and resilience through intercultural music engagement. This project aims to identify, evaluate and develop theoretical and practical ways in which intercultural music engagement can facilitate social cohesion and enhance community resilience and intercultural empathy. There is growing evidence that music is a powerful stimulus for wellbeing and interpersonal connection and it is increasingly applied to promote intercultural understanding. This project will use detailed observatio ....Social cohesion and resilience through intercultural music engagement. This project aims to identify, evaluate and develop theoretical and practical ways in which intercultural music engagement can facilitate social cohesion and enhance community resilience and intercultural empathy. There is growing evidence that music is a powerful stimulus for wellbeing and interpersonal connection and it is increasingly applied to promote intercultural understanding. This project will use detailed observational, participatory and experimental strategies to elucidate the psychosocial processes underpinning intercultural music engagement, isolating variables that promote social cohesion. The project will develop best practice guidelines for organisations seeking to use cultural exposure and interaction to promote positive multicultural experiences.Read moreRead less
The Integrated Bio-economy Project and the Controlled Biosphere. This project aims to develop advanced controlled environment production systems (Controlled Biosphere) that exceed the industry standard for profitability, sustainability and climatic resilience. It will generate new knowledge and innovations in technology integration through a highly multi-disciplinary approach. The project outcomes will yield Techno-Economic and Life-Cycle Analyses, designs of the Controlled Biosphere and support ....The Integrated Bio-economy Project and the Controlled Biosphere. This project aims to develop advanced controlled environment production systems (Controlled Biosphere) that exceed the industry standard for profitability, sustainability and climatic resilience. It will generate new knowledge and innovations in technology integration through a highly multi-disciplinary approach. The project outcomes will yield Techno-Economic and Life-Cycle Analyses, designs of the Controlled Biosphere and supporting policy frameworks. The benefits of this project address worsening resource constraints (e.g. available fresh water, arable land, nutrients); By 2050 we will require 70% more food, and 80% greenhouse gas emissions reductions, to maintain economic, social, political and climate security.Read moreRead less