Immediate And Long-term Safety Of Prescription Opioids In Pregnancy
Funder
National Health and Medical Research Council
Funding Amount
$447,603.00
Summary
Little is known about the consequences of prescription opioid use during pregnancy for fetal and childhood development. In this study covering over 5 million mother-child pairs, we will investigate the safety of opioid use in pregnancy, by combining rich data sources from Australia, and the 5 Nordic countries. We will translate findings into policy, guidelines and messaging for medicine consumers and prescribers to protect the safety of women and children.
IRON IN DISEASES OF THE AGEING BRAIN: From Bench To Clinic
Funder
National Health and Medical Research Council
Funding Amount
$1,814,215.00
Summary
I aim to achieve a deeper understanding of the causes, detection and treatment of incurable neurological diseases of advancing age - Alzheimer’s disease, Parkinson’s disease and Motor Neuron Disease. Iron needlessly accumulates in brain tissue with age. I will pursue studies of ageing worms, cells in culture, mice, human brain tissue, brain imaging and clinical trials, to determine whether the problem of iron accumulation is a drug target for these diseases.
Targeting Iron Piracy From Host Proteins By Neisseria And Haemophilus Spp. For The Development Of Novel Antimicrobials
Funder
National Health and Medical Research Council
Funding Amount
$645,205.00
Summary
The bacteria that cause the sexually transmitted infection gonorrhoea and meningococcal disease are a serious health concern. In order to cause disease, these bacteria must obtain the nutrient iron from our bodies. This proposed research will use cutting edge technologies to understand on a molecular level how these bacteria obtain iron during infection. It will then apply this knowledge to develop molecules that prevent these bacteria from obtaining iron, as a means of treating these diseases.
Improving Outcomes And Cost Of Systemic Sclerosis Related Pulmonary Arterial Hypertension
Funder
National Health and Medical Research Council
Funding Amount
$645,205.00
Summary
My research program aims to improve the outcomes for those living with systemic sclerosis related pulmonary arterial hypertension (SSc-PAH) and reduce its associated societal burden through the evaluation and implementation of a novel PAH screening algorithm; the use of risk stratification tools in therapeutic decisions; and the development of a more streamlined management approach. My research will initiate collaboration across multiple medical disciplines and sites nationally.
There has been no significant breakthrough in the treatment of Systemic Lupus Erythematosus (SLE) for over 50 years. Treatment continues to rely on non-specific immunosuppressant drugs and glucocorticoids (GC, or ‘steroids’), and the impact on patients includes high mortality and poor quality of life. In this proposal, I will validate novel endpoints which will break the impasse in SLE drug development and develop tools for minimising GC use in SLE.
The Role Of Preconception And Perinatal Substance Use And Misuse In Childhood Social, Emotional And Behavioural Problems
Funder
National Health and Medical Research Council
Funding Amount
$1,562,250.00
Summary
This project will use perinatal and preconception data from three long-running Australian studies that have tracked the health and wellbeing of several thousand participants prior to parenthood. The aim is to understand how parental histories of substance use, and patterns of use during pregnancy, and in early life, shape offspring social, emotional and behavioural outcomes across childhood. Results will inform new approaches to preventing substance-related harms within and across generations.
Better Evidence And New Tools To Improve Health After Surgical Menopause
Funder
National Health and Medical Research Council
Funding Amount
$1,855,260.00
Summary
Surgical menopause is removal of both ovaries before natural menopause. Surgical menopause may have severe adverse health consequences including short-term symptoms and long-term risk of chronic disease, but more information is needed to inform evidence-based care. This study will deliver the best available evidence internationally on the short (up to 5 year) and long (>20 year) consequences of surgical menopause and new tools for clinicians and patients to integrate this evidence into practi ....Surgical menopause is removal of both ovaries before natural menopause. Surgical menopause may have severe adverse health consequences including short-term symptoms and long-term risk of chronic disease, but more information is needed to inform evidence-based care. This study will deliver the best available evidence internationally on the short (up to 5 year) and long (>20 year) consequences of surgical menopause and new tools for clinicians and patients to integrate this evidence into practiceRead moreRead less
Bridging The Gap: Using Data Science To Transform Care And Health Outcomes In Kidney Transplant Recipients
Funder
National Health and Medical Research Council
Funding Amount
$1,155,135.00
Summary
Despite substantive survival and quality of life benefits compared to being on dialysis, kidney transplant recipients suffer from premature death, largely due to complications such as cancer and cardiovascular. Using big data science, we will be able to predict these complications in the context of chronic immunosuppression, find new and better ways to identify at risk individuals, to deliver effective and efficient screening and treatment strategies in this vulnerable population.
Innovation For Health Service Provision And Clinical Management Of Cardiovascular Disease Prevention
Funder
National Health and Medical Research Council
Funding Amount
$1,338,220.00
Summary
Cardiovascular disease (CVD) remains the leading cause of morbidity and mortality globally and had a steep rise in burden in low- and middle income countries. A greater focus on a preventative model of care is needed. Frugal innovation is the concept of creating small, low-cost solutions to big problems. My goal is to discover and robustly evaluate in real-world setting low-cost interventions that can be scaled and implemented to reduce the burden of CVD globally.
LIFESPAN-CHD – Leading Innovation By Finding And Eliminating Gaps In Research, SPecialist Care ANd Mental Health Services For People With CHD.
Funder
National Health and Medical Research Council
Funding Amount
$462,644.00
Summary
Keeping patients and families engaged in congenital heart disease (CHD) care is vital for improving health outcomes for Australians living with CHD. This collaboration will position Australia at the forefront of CHD care and research by delivering healthcare innovations including a national CHD health services dataset, a digital health tool that maximises engagement in CHD care and new models of care co-designed with CHD patients and families to meet their cardiac and mental health needs.