Resolving multi-sensory conflict as we age: audio-visual integration and the role of normal and abnormal sensory decline. Australia has an ageing population. Even the healthiest older individuals undergo some deterioration of vision and hearing, however, these senses are almost invariably studied in isolation. The real world is multisensory. This project will enhance our knowledge of how ageing impacts on the interpretation of visual and auditory information regarding the timing and location of ....Resolving multi-sensory conflict as we age: audio-visual integration and the role of normal and abnormal sensory decline. Australia has an ageing population. Even the healthiest older individuals undergo some deterioration of vision and hearing, however, these senses are almost invariably studied in isolation. The real world is multisensory. This project will enhance our knowledge of how ageing impacts on the interpretation of visual and auditory information regarding the timing and location of objects; essential precursors to many real world tasks, for example: driving, interpreting speech, and hazard avoidance. This knowledge is essential for the optimisation of audio-visual environments for the elderly, and for the development of tools to improve performance in the presence of sensory decline due to age-related eye disease.Read moreRead less
Dissecting chloride transport in plants to secure an untapped source for improving plant productivity. Chloride and nitrate are central to physiological processes that determine crop yield and food production, but their uptake and transport within the plant body are antagonistic. This project will gain a fundamental understanding of the mechanisms underlying this antagonism. This will provide new tools for improving salinity tolerance and the efficiency of fertiliser use, which can be used for t ....Dissecting chloride transport in plants to secure an untapped source for improving plant productivity. Chloride and nitrate are central to physiological processes that determine crop yield and food production, but their uptake and transport within the plant body are antagonistic. This project will gain a fundamental understanding of the mechanisms underlying this antagonism. This will provide new tools for improving salinity tolerance and the efficiency of fertiliser use, which can be used for the development of new crop varieties. Improving these traits will be essential if we are to successfully address the threats to Australian and global food security posed by salinity, and the rising economic and environmental costs of inefficient fertiliser use.Read moreRead less
Unravelling the secrets of the rhizosphere of crops. Phosphate is one of the most important limiting nutrients for crop growth and production. Plant acquisition of soil phosphate largely depends on root proliferation to accelerate soil exploration, and on phosphate bioavailability mediated by root exudates and rhizosphere microorganisms. Central to this is the need for a better understanding of the complex biogeochemical interfaces in the rhizosphere. This project explores recently developed non ....Unravelling the secrets of the rhizosphere of crops. Phosphate is one of the most important limiting nutrients for crop growth and production. Plant acquisition of soil phosphate largely depends on root proliferation to accelerate soil exploration, and on phosphate bioavailability mediated by root exudates and rhizosphere microorganisms. Central to this is the need for a better understanding of the complex biogeochemical interfaces in the rhizosphere. This project explores recently developed non-destructive imaging, isotope, and metabolism techniques to generate a systematic research tool in tracking rhizosphere interactions and imaging phosphate dynamics from macroscale to nanoscale levels. This study will provide new opportunities to improve crop nutrient use efficiency and crop production.Read moreRead less
Determining how calcium regulates mitochondrial function in models of cardiomyopathy. Heart failure is the leading cause of death in Australia. This project will determine the mechanisms by which the failing heart is associated with disorganisation of the cell and poor energy supply so that interventions aimed at reducing the development of heart failure can be developed.
Regulation and role of metabolic networks for respiration in plants. This project aims to understand the regulation of respiration in plants which underpins the energy provision that cells need to operate. Understanding respiration and how it responds to the changing environment is a building block needed for rational engineering of our future food from plants.
Characterizing the regulators of mitochondrial biogenesis in Arabidopsis thaliana. The overall aim of this project is to identify and characterise the underlying regulatory factors that control mitochondrial mass and number in plants. The project will exploit a regulatory mechanism that links the mitochondrial import machinery and the respiratory chain. Utilising both forward and reverse genetic approaches, the abundances of protein import translocases will be altered and the changes to mitochon ....Characterizing the regulators of mitochondrial biogenesis in Arabidopsis thaliana. The overall aim of this project is to identify and characterise the underlying regulatory factors that control mitochondrial mass and number in plants. The project will exploit a regulatory mechanism that links the mitochondrial import machinery and the respiratory chain. Utilising both forward and reverse genetic approaches, the abundances of protein import translocases will be altered and the changes to mitochondrial biogenesis will be investigated. This will identify regulatory factors, which can be manipulated and used to alter mitochondrial number and activity.Read moreRead less
Crops for a phosphorus-scarce future: plant adaptation to fluctuating phosphorus availability. Phosphorus is commonly used on farmland to ensure high yields. However, rock phosphate reserves are declining and leaching of phosphorus from farmlands into native vegetation and water bodies causes significant environmental degradation. As a result, more phosphorus-efficient farming systems are urgently required. Many Australian native plants have adapted to low phosphorus soils and fast fluctuations ....Crops for a phosphorus-scarce future: plant adaptation to fluctuating phosphorus availability. Phosphorus is commonly used on farmland to ensure high yields. However, rock phosphate reserves are declining and leaching of phosphorus from farmlands into native vegetation and water bodies causes significant environmental degradation. As a result, more phosphorus-efficient farming systems are urgently required. Many Australian native plants have adapted to low phosphorus soils and fast fluctuations in phosphorus availability. This project aims to investigate plant adaptations to phosphorus fluctuations and the potential for storing phosphorus when it is abundant for later use. This should aid development of crops with improved phosphorus fertiliser-use efficiency in anticipation of a phosphorus-scarce future.Read moreRead less
Deciphering the Thermal Acclimation of Mitochondrial Respiration. Plants acclimate to the extremes of temperature following a pre-exposure to a sub-lethal increase/decrease in temperature. Recent research has revealed that proteins of oxidative phosphorylation and the tricarboxylic acid (TCA) cycle are dynamic and change their abundance in response to temperature change. Harnessing a cutting edge protein mass spectrometry approach, this project seeks to better understand how mitochondrial respir ....Deciphering the Thermal Acclimation of Mitochondrial Respiration. Plants acclimate to the extremes of temperature following a pre-exposure to a sub-lethal increase/decrease in temperature. Recent research has revealed that proteins of oxidative phosphorylation and the tricarboxylic acid (TCA) cycle are dynamic and change their abundance in response to temperature change. Harnessing a cutting edge protein mass spectrometry approach, this project seeks to better understand how mitochondrial respiration and hence adenosine triphosphate (ATP) production is maintained during temperature change. Uniquely this project will examine this in both the model plant Arabidopsis and wheat and combine both tissue, environment-induced and genotype variation to reveal a new understanding of the thermal acclimation of this major mitochondrial process.Read moreRead less
Masterminding Reproduction: Kisspeptin and RFamide-Related Peptide. There are a number of concerning trends in reproductive health. Women are reporting difficulty conceiving and maintaining pregnancies; while sperm count and quality are declining in men. More concerning is the increase in reproductive cancers. Gonadotropin-releasing hormone (GnRH) antagonist and agonist have been used for decades to treat reproductive cancers (such as breast cancer and prostate cancer), infertility and precociou ....Masterminding Reproduction: Kisspeptin and RFamide-Related Peptide. There are a number of concerning trends in reproductive health. Women are reporting difficulty conceiving and maintaining pregnancies; while sperm count and quality are declining in men. More concerning is the increase in reproductive cancers. Gonadotropin-releasing hormone (GnRH) antagonist and agonist have been used for decades to treat reproductive cancers (such as breast cancer and prostate cancer), infertility and precocious puberty. Kisspeptin and RF-related peptide may offer more physiological alternatives to GnRH, without detrimental side effects. We will fully explore these two newly defined and major players in reproduction and provide a physiological framework for their progression to clinical use.Read moreRead less
Dissecting novel roles of succinate dehydrogenase in stomatal aperture and root elongation in plants. Succinate dehydrogenase (complex II) is part of the respiration processes in plants and new evidence shows that reactive oxygen species generated by it can influence plant development and stress tolerance. However, there are still many unanswered questions about the composition and function of this enzyme and its dual roles in plants. This project will study this protein complex in the model p ....Dissecting novel roles of succinate dehydrogenase in stomatal aperture and root elongation in plants. Succinate dehydrogenase (complex II) is part of the respiration processes in plants and new evidence shows that reactive oxygen species generated by it can influence plant development and stress tolerance. However, there are still many unanswered questions about the composition and function of this enzyme and its dual roles in plants. This project will study this protein complex in the model plant Arabidopsis and the crop plant rice, identify its role in signalling in depth to provide knowledge adding development of strategies for improving tolerance of crops to stresses.Read moreRead less