Physiology of oxygen transport in the mammalian kidney. This project aims to improve understanding of oxygen regulation in renal tissue and knowledge of the physiology of the kidney. The mammalian kidney receives more oxygen than it uses or needs, and yet renal tissue is commonly found to be hypoxic. This project proposes that oxygen transport to the renal tissue is limited by blood vessel surface area. The project expects to generate anatomical data currently missing from the renal physiology c ....Physiology of oxygen transport in the mammalian kidney. This project aims to improve understanding of oxygen regulation in renal tissue and knowledge of the physiology of the kidney. The mammalian kidney receives more oxygen than it uses or needs, and yet renal tissue is commonly found to be hypoxic. This project proposes that oxygen transport to the renal tissue is limited by blood vessel surface area. The project expects to generate anatomical data currently missing from the renal physiology community, and potentially change the accepted story of oxygen homeostasis in the kidney. This will provide significant benefits, such as the provision of the foundational physiological science behind a determinant of kidney health and its flow-on impact to quality of life.Read moreRead less
Using visual science to reduce the dangers of night driving. This project aims to develop novel tests of visual function relevant to the modern night driving environment. Night driving is challenging for all drivers and has been linked to poor visibility under low light conditions. This project will characterise the visual challenges of the modern night driving environment, develop visual tests that incorporate the dynamic light levels typical of night-time roads and assess the association of th ....Using visual science to reduce the dangers of night driving. This project aims to develop novel tests of visual function relevant to the modern night driving environment. Night driving is challenging for all drivers and has been linked to poor visibility under low light conditions. This project will characterise the visual challenges of the modern night driving environment, develop visual tests that incorporate the dynamic light levels typical of night-time roads and assess the association of these tests with night driving performance. The outcomes will contribute new knowledge regarding dynamic visual processing and the ageing visual system and will inform vision testing, potential interventions to improve visual function for night driving and reduce the dangers of night driving.Read moreRead less
Listen and learn - statistical learning and the adapting auditory brain. This project aims to explore the link between rapid neural adaptation - a form of learning referred to as statistical learning - and human listening performance in noisy environments. The project aims to generate a new understanding of mechanisms that contribute to listeners' abilities to understand speech in noise, and to complex communication disorders such as dyslexia. Expected outcomes will include increased capacity to ....Listen and learn - statistical learning and the adapting auditory brain. This project aims to explore the link between rapid neural adaptation - a form of learning referred to as statistical learning - and human listening performance in noisy environments. The project aims to generate a new understanding of mechanisms that contribute to listeners' abilities to understand speech in noise, and to complex communication disorders such as dyslexia. Expected outcomes will include increased capacity to investigate a broad range of cognitive and communication functions. Benefits will include potential technologies and algorithms to assist listening (in devices such as hearing aids), language development and reading.Read moreRead less
Neural plasticity in older adult human vision. This project aims to expand our understanding of age related changes in brain function, specifically plasticity. The project will increase knowledge of the role of an inhibitory neurotransmitter GABA in visual plasticity. Expected outcomes include new knowledge regarding the regulation of brain function in adulthood, enabling future research and planning for societal benefit to older Australia.
Reducing environmental footprint by improving phosphorous use efficiency. While modern agriculture relies heavily on the use of phosphorous fertilizers, most of them are not used by plants and lost in runoff, resulting in a massive environmental damage through contamination of waterways (termed eutrophication). This project takes advantage of an untapped resource - a unique collection of Tibetan wild barley genotypes, to reveal key traits that confer superior phosphorus use efficiency in wild ba ....Reducing environmental footprint by improving phosphorous use efficiency. While modern agriculture relies heavily on the use of phosphorous fertilizers, most of them are not used by plants and lost in runoff, resulting in a massive environmental damage through contamination of waterways (termed eutrophication). This project takes advantage of an untapped resource - a unique collection of Tibetan wild barley genotypes, to reveal key traits that confer superior phosphorus use efficiency in wild barley and identify appropriate candidate genes and their position on chromosomes for further incorporating these traits into commercial barley cultivars. This will reduce the environmental footprint of modern agricultural practices on terrestrial and aquatic ecosystems without compromising food security.Read moreRead less
Does word similarity across languages help or hinder bilingual speakers? This project aims to understand in more detail how bilinguals can accurately speak in both their languages. Speaking is a complex skill, particularly if you have two languages to choose from, which will be true for over half of Australia’s population by 2025. This project aims to investigate the factors that influence speech production in both monolinguals and bilinguals including those with language impairment, and develop ....Does word similarity across languages help or hinder bilingual speakers? This project aims to understand in more detail how bilinguals can accurately speak in both their languages. Speaking is a complex skill, particularly if you have two languages to choose from, which will be true for over half of Australia’s population by 2025. This project aims to investigate the factors that influence speech production in both monolinguals and bilinguals including those with language impairment, and develop a better bilingual theory. The benefit of this new theory will be to provide a clear basis for diagnosis and treatment for children in bilingual households who have problems learning to speak, and for bilingual people with language problems after a stroke or dementia.Read moreRead less
Investigating a novel signalling pathway for crop improvement. This project will dissect a newly identified signalling pathway in plants that regulates plant water use and carbon gain. It will deploy multiple techniques, including novel biosensors, to understand the links between the metabolism of plants and their environmental responses. The project will build partnerships with scientists at leading international institutions for enhanced outcomes, including access to specialised equipment and ....Investigating a novel signalling pathway for crop improvement. This project will dissect a newly identified signalling pathway in plants that regulates plant water use and carbon gain. It will deploy multiple techniques, including novel biosensors, to understand the links between the metabolism of plants and their environmental responses. The project will build partnerships with scientists at leading international institutions for enhanced outcomes, including access to specialised equipment and upskilling of our scientists. The generation of barley with the latest gene editing techniques aims to produce a non-GM crop with the potential for enhanced root C sequestration, lower water use and improved yield, three key goals for agricultural sustainability in the face of a drying Australian climate.Read moreRead less
Mitochondrial Biogenesis and Signalling in Plants . This proposal aims to define the mechanisms of how mitochondrial growth and stress signalling interact and are regulated. Mitochondria are central machines in cells that use energy obtained through photosynthesis to drive growth and also play an important role in sensing and responding to non-optimal environmental growth conditions. As mitochondrial growth and stress signalling are antagonistic, growth is retarded when stress signalling is acti ....Mitochondrial Biogenesis and Signalling in Plants . This proposal aims to define the mechanisms of how mitochondrial growth and stress signalling interact and are regulated. Mitochondria are central machines in cells that use energy obtained through photosynthesis to drive growth and also play an important role in sensing and responding to non-optimal environmental growth conditions. As mitochondrial growth and stress signalling are antagonistic, growth is retarded when stress signalling is activated. Thus, the outcomes will be new knowledge and understanding of how plants balance growth and stress responses. This benefit of this knowledge and understanding is that it can be used to pursue novel avenues to optimise crop performance in changing and adverse environments.Read moreRead less
Tightening the phosphorus cycle for grain legumes. Using unique core collections of chickpea, soybean and peanut with diverse genetic backgrounds, this project aims to unravel the mechanisms underlying high phosphorus-use efficiency (PUE) at morphological, physiological, biochemical and molecular levels in three major legume crops. Reduced levels of phosphorus and phytate in seeds will improve seed quality for humans and livestock and dramatically reduce phosphorus-fertiliser inputs. The identif ....Tightening the phosphorus cycle for grain legumes. Using unique core collections of chickpea, soybean and peanut with diverse genetic backgrounds, this project aims to unravel the mechanisms underlying high phosphorus-use efficiency (PUE) at morphological, physiological, biochemical and molecular levels in three major legume crops. Reduced levels of phosphorus and phytate in seeds will improve seed quality for humans and livestock and dramatically reduce phosphorus-fertiliser inputs. The identification of traits and genes associated with high PUE will allow transfer of key traits into commercial cultivars using molecular breeding approaches. Cultivars with improved PUE will enable reduced phosphate fertiliser input and loss of phosphate in runoff from agricultural systems.Read moreRead less
Facilitation of high leaf phosphorus-use efficiency by nitrate restraint. This project aims to determine the link between high phosphorus use efficiency and nitrogen metabolism in the Fabaceae, Myrtaceae and Proteaceace, the three families of plants that co-dominate the flora on the extremely phosphorus-impoverished soils of south-western Australia, a Global Biodiversity Hotspot. It is expected that the extremely high phosphorus use efficiency in these plants is inextricably linked to a low capa ....Facilitation of high leaf phosphorus-use efficiency by nitrate restraint. This project aims to determine the link between high phosphorus use efficiency and nitrogen metabolism in the Fabaceae, Myrtaceae and Proteaceace, the three families of plants that co-dominate the flora on the extremely phosphorus-impoverished soils of south-western Australia, a Global Biodiversity Hotspot. It is expected that the extremely high phosphorus use efficiency in these plants is inextricably linked to a low capacity for nitrogen uptake. An anticipated outcome is new insight into how these plants achieve highly efficient phosphorus and nitrogen use, providing new understanding into the functioning of plants in an exceptionally biodiverse ecosystem and into traits that may lead to to crops with higher fertilizer use efficiency.Read moreRead less