Ultra-low fouling active surfaces. This project aims to develop chemistries and fabrication approaches through innovative materials evaluation to develop ultra-low fouling active electrode surfaces. Development of ultra-low fouling surfaces will have significant impact in a range of applications where system or device failure is attributed to fouling. The growing field of bionics, where implantable electronic devices interface directly with the nervous system, is one such device. The expected ou ....Ultra-low fouling active surfaces. This project aims to develop chemistries and fabrication approaches through innovative materials evaluation to develop ultra-low fouling active electrode surfaces. Development of ultra-low fouling surfaces will have significant impact in a range of applications where system or device failure is attributed to fouling. The growing field of bionics, where implantable electronic devices interface directly with the nervous system, is one such device. The expected outcomes will be an understanding of the material requirements that lead to the elimination of protein and cell accumulation at surfaces that degrades the performance and lifetime of these implants. The findings will benefit any application where fouling is a problem.Read moreRead less
Modelling human brain development with stem cells and biomaterials. With limited resources to directly study and advance our understanding of human neural development, this
proposal will establish models of 4 key stages. Employing innovative, interdisciplinary approaches, biomaterials will be fabricated to provide structural and chemical support for human stem cells during: (i) neural induction, (ii) specification into neuronal progenitor subpopulations, (iii) neuronal maturation and integration ....Modelling human brain development with stem cells and biomaterials. With limited resources to directly study and advance our understanding of human neural development, this
proposal will establish models of 4 key stages. Employing innovative, interdisciplinary approaches, biomaterials will be fabricated to provide structural and chemical support for human stem cells during: (i) neural induction, (ii) specification into neuronal progenitor subpopulations, (iii) neuronal maturation and integration into complex neural networks as well as, (iv) the organisation of neurons into larger 3-dimensional brain structures, namely folding of the human cortex. Further, biomaterials developed here have commercialisation potential, targeted at standardizing the culturing of human stem cells to defined neural populations.
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Biological determinants of the safety and stability of neuroprosthetic stimulation electrodes. Performance of cochlear implants and the quality of sound perceived by patients is strongly related to electrode impedance. Electrode impedance fluctuates relative to the implant electrical activity, but the mechanisms which cause this are not clear. This project aims to investigate the role of protein adsorption in electrode performance, including impedance and material dissolution. To enable these in ....Biological determinants of the safety and stability of neuroprosthetic stimulation electrodes. Performance of cochlear implants and the quality of sound perceived by patients is strongly related to electrode impedance. Electrode impedance fluctuates relative to the implant electrical activity, but the mechanisms which cause this are not clear. This project aims to investigate the role of protein adsorption in electrode performance, including impedance and material dissolution. To enable these investigations a new biomimetic analogue of the perilymph (cochlea fluid) is intended to be developed. Additionally, the project aims to investigate two strategies to minimise impedance changes: small pulse electrode cleaning and antifouling coatings. Understanding and control of factors influencing electrode stability aim to facilitate next-generation implant designs.Read moreRead less
Targeting electrical stimulation of neural tissue. This project aims to develop a platform of mathematical methods for targeting electrical stimulation of neural tissue. The proposed methods work by selecting the amplitude and polarity of each stimulating electrode in an array based on a desired pattern of neural activation. The algorithms are particularly applicable to high-density electrode arrays. The project will work with an Australian industry leader to provide significant benefits to Aust ....Targeting electrical stimulation of neural tissue. This project aims to develop a platform of mathematical methods for targeting electrical stimulation of neural tissue. The proposed methods work by selecting the amplitude and polarity of each stimulating electrode in an array based on a desired pattern of neural activation. The algorithms are particularly applicable to high-density electrode arrays. The project will work with an Australian industry leader to provide significant benefits to Australia’s high-tech sector through increased knowledge and capacity.Read moreRead less
Feedthrough technologies for polymeric encapsulated active implants. The project will address the scientific challenges of signal transfer between tissue and novel active implantable medical devices, with major implications for cochlear implant manufacture. This will lead to improvements in the quality of life of the hearing-impaired, and will make an important contribution to the development of other sensory implants.
Platform technology to decode motor control through ultra high-field MRI. This project aims to advance our understanding of the poorly understood neural circuits that enable fine motor control in humans. To obtain this knowledge, new platform technology will be developed to capture the full kinematics of the hand during concurrent functional magnetic resonance imaging at ultra high-field. This device will allow testing of fundamental theories describing the canonical microcircuits involved in ha ....Platform technology to decode motor control through ultra high-field MRI. This project aims to advance our understanding of the poorly understood neural circuits that enable fine motor control in humans. To obtain this knowledge, new platform technology will be developed to capture the full kinematics of the hand during concurrent functional magnetic resonance imaging at ultra high-field. This device will allow testing of fundamental theories describing the canonical microcircuits involved in hand motion. Expected outcomes include new evidence of mirror neurons and observation of predictive error signals in the motor cortex. This new knowledge paves the way towards improved computer-brain interface technology which is likely to create benefits through translation to applications such as artificial limb control.Read moreRead less
Developmental trajectory of tongue control for speech with real-time MRI. This project aims to evaluate the developmental trajectory of tongue control during speech, relating dynamic 3D vocal tract modelling to the acoustic signal. By optimising real-time MRI technology to capture and model articulatory movements, the project expects to accelerate understanding of how tongue control for speech is developed, mastered, and perturbed by factors such as rapid growth and foreign accent. Expected outc ....Developmental trajectory of tongue control for speech with real-time MRI. This project aims to evaluate the developmental trajectory of tongue control during speech, relating dynamic 3D vocal tract modelling to the acoustic signal. By optimising real-time MRI technology to capture and model articulatory movements, the project expects to accelerate understanding of how tongue control for speech is developed, mastered, and perturbed by factors such as rapid growth and foreign accent. Expected outcome is a new understanding of how different speakers' vocal tracts change and how speech is reshaped, informed by real physiological data. Significant benefits will be realised through refined methods and theory development for diverse fields e.g. linguistics, speech science, and automatic speech recognition/synthesis. Read moreRead less
Computational neural modelling of bottom-up information and top-down attention in auditory perception. The aim of this project is to gain a better understanding of the ways in which our auditory cortex functions. This project will make a significant contribution to this important and fundamental aspect of brain science and brain-inspired computation. The outcome will be to build a computational model of the auditory cortex, through simulation of the detailed neuronal responses using spiking neur ....Computational neural modelling of bottom-up information and top-down attention in auditory perception. The aim of this project is to gain a better understanding of the ways in which our auditory cortex functions. This project will make a significant contribution to this important and fundamental aspect of brain science and brain-inspired computation. The outcome will be to build a computational model of the auditory cortex, through simulation of the detailed neuronal responses using spiking neurons. Applications will develop improved processing strategies for automatic speech recognition, hearing aids, bionic ears (cochlear implants), robotics and other machine processing systems.Read moreRead less
The structure and function of the human spinal connectome. This project will use complex network analysis to map the interactions between the brain and body, to understand how the central nervous system controls our movements. The project will provide fundamental insights into mechanisms that coordinate activity in the human motor system, and how the breakdown of coordination may lead to movement disorders. By integrating advanced computational analyses with state-of-the-art recording techniques ....The structure and function of the human spinal connectome. This project will use complex network analysis to map the interactions between the brain and body, to understand how the central nervous system controls our movements. The project will provide fundamental insights into mechanisms that coordinate activity in the human motor system, and how the breakdown of coordination may lead to movement disorders. By integrating advanced computational analyses with state-of-the-art recording techniques, the project will generate new knowledge of the neural basis of human motor coordination. Expected outcomes may support future applications to restore motor function through brain stimulation, prosthetics and robotics design.Read moreRead less
Generating multi-component scaffolding to influence the differentiation of embryonic stem cells. Nervous system diseases are debilitating and will develop in over 50 per cent of people at some time in their life. This project will develop strategies so that stem cells can be utilised to encourage brain repair for the treatment of Parkinson's disease. The technology developed will also be of benefit for the treatment of other nervous system disorders.