Innovative Health Programs To Reduce Inequality In Heart Disease
Funder
National Health and Medical Research Council
Funding Amount
$876,005.00
Summary
As part of his Senior NHMRC Fellowship, Prof Simon Stewart, a world-renowned health services researcher, will lead an internationally linked team of researchers from a broad range of health disciplines to undertake a program of research designed to improve the lives of those most vulnerable to heart disease and poor health outcomes. His program of research will focus on Indigenous Australians, patients with complex forms of heart disease and urban African communities in economic transition.
Evaluating The Genetic Contribution To Rheumatic Heart Disease Pathogenesis In Australian Aboriginal And Torres Strait Islander Communities
Funder
National Health and Medical Research Council
Funding Amount
$1,782,074.00
Summary
Rheumatic heart disease is highly prevalent in Aboriginal people in Australia and leads to early cardiac disease. Despite decades of research, the underlying genetic mechanisms for why it occurs are not well understood. We are conducting a genetic study to better understand why some people are susceptible to RHD and others are not. The study will involve substantial Aboriginal leadership and consultation and will be a model for the conduct of genetic studies in Aboriginal populations.
Can Skin Infection With Group A Streptococcus Cause Acute Rheumatic Fever?
Funder
National Health and Medical Research Council
Funding Amount
$459,450.00
Summary
It is traditionally taught that the cause of acute rheumatic fever (ARF) is always infection of the throat with the bacterium group A streptococcus (GAS). However, in Aboriginal communities of the Top End of the Northern Territory the incidence of ARF is the highest reported in the world, yet GAS is uncommonly isolated from the throat. There is further information to suggest that GAS skin sores may underlie many cases of ARF. If this were proven, it would completely alter the traditional view of ....It is traditionally taught that the cause of acute rheumatic fever (ARF) is always infection of the throat with the bacterium group A streptococcus (GAS). However, in Aboriginal communities of the Top End of the Northern Territory the incidence of ARF is the highest reported in the world, yet GAS is uncommonly isolated from the throat. There is further information to suggest that GAS skin sores may underlie many cases of ARF. If this were proven, it would completely alter the traditional view of the cause of ARF, and have important implications for prevention of ARF around the world. Presently, these approaches focus on diagnosing and treating sore throat, but no country has proven that such a program can be successful in substantially reducing new cases of ARF. If it was known that skin infection could lead to ARF, then countries (including Australia) could emphasise the importance of skin health programs. A further benefit of this knowledge would be to influence GAS vaccine development, which presently is largely focused on the prevention of sore throat. A different possibility has recently been raised - that the cause of ARF may not always be GAS, but instead that the related bacteria GCS and GGS may have the potential to cause this disease. Proof of this hypothesis would even more dramatically alter our understanding of disease causation, prevention, and vaccine development. We propose to determine the cause of ARF in Aboriginal communities by regularly swabbing families of people with a history of ARF, and using genetic fingerprinting of the bacteria from the skin and throat swabs. When cases of ARF occur, we will be able to determine the site and type of infection that precipitated the attack. We will conduct a related study in more communities, in which we will swab family members of people with ARF and of control families (without ARF) to determine the bacteria most commonly isolated from ARF families.Read moreRead less
CENTRE OF RESEARCH EXCELLENCE TO REDUCE INEQUALITY IN HEART DISEASE
Funder
National Health and Medical Research Council
Funding Amount
$2,607,253.00
Summary
There is increasing recognition of a societal responsibility to provide effective and sustainable health care to the entire population and not just to selected parts. Indigenous and regional Australians are most affected by Australia's biggest killer - heart disease. In response, the CRE to Reduce Inequality in Heart Disease, is a national collaboration of researchers from a range of health disciplines. Together they aim to address this problem by developing sustainable and cost-effective health ....There is increasing recognition of a societal responsibility to provide effective and sustainable health care to the entire population and not just to selected parts. Indigenous and regional Australians are most affected by Australia's biggest killer - heart disease. In response, the CRE to Reduce Inequality in Heart Disease, is a national collaboration of researchers from a range of health disciplines. Together they aim to address this problem by developing sustainable and cost-effective health care services.Read moreRead less
A National Population-based Study Of Rheumatic Heart Disease In Pregnancy
Funder
National Health and Medical Research Council
Funding Amount
$877,826.00
Summary
Whilst overall a rare disease, Indigenous peoples have disproportionately high rates of rheumatic heart disease (RHD). This study explores the prevalence and distribution of RHD in pregnancy in Australia and New Zealand. It details current management, diagnostic and referral process and risk factors. Key attributes of culturally safe models of care for RHD in pregnancy are explored, particularly as they relate to Indigenous women. Findings will inform policy, guidelines and education resources.
Mothers' little helper: Alcohol use in working mothers. This project aims to generate unique insights into the strains that Australian working mothers face in their daily lives and the impact these strains have on their alcohol consumption. Using innovative methods to understand strains resulting from two major life domains, family and work, the project expects to generate new knowledge which can be used to develop interventions to address this important issue. The results of this study can prov ....Mothers' little helper: Alcohol use in working mothers. This project aims to generate unique insights into the strains that Australian working mothers face in their daily lives and the impact these strains have on their alcohol consumption. Using innovative methods to understand strains resulting from two major life domains, family and work, the project expects to generate new knowledge which can be used to develop interventions to address this important issue. The results of this study can provide significant benefits not only to the quality of life of working mothers in Australia but also has society-wide implications. This is due to alcohol use being a leading avoidable cause for productivity loss alongside other social, community and economic costs.Read moreRead less
The invisible farmer: Securing Australian farm women's history. The invisible farmer: Securing Australian farm women's history. This project, believed to be the first national study of farm women in Australia, aims to address their historical and contemporary invisibility by creating an online, publicly accessible, multimedia documentary database that maps the role women play/played in Australian agriculture. Chief investigators in the fields of social work, women's history, cultural informatics ....The invisible farmer: Securing Australian farm women's history. The invisible farmer: Securing Australian farm women's history. This project, believed to be the first national study of farm women in Australia, aims to address their historical and contemporary invisibility by creating an online, publicly accessible, multimedia documentary database that maps the role women play/played in Australian agriculture. Chief investigators in the fields of social work, women's history, cultural informatics and archival practice will collaborate with community, government and cultural organisations to create digital tools for research, public access and community engagement. Reframing the narrative of rural Australia is expected to create greater understanding and awareness of the value of inclusion, reveal structures of gender inequality in rural communities, and enable significant outcomes in research, industry and public policy.Read moreRead less
Enhancing linkage and exchange in a national research partnership to improve primary health care performance and outcomes for Indigenous peoples. This project will enhance current efforts to make high-quality primary health care services accessible to all Indigenous Australians. The work will result in widespread application of systematic and cutting-edge methods to enable health service staff and managers to review and continually work to improve the quality of their service.