Eliminating HCV: Statistical Modelling And Health Economic Evaluation In The New DAA Era
Funder
National Health and Medical Research Council
Funding Amount
$318,768.00
Summary
While new generation hepatitis C virus (HCV) treatments are highly efficacious, their high cost means multi-pronged approaches will be needed to reach elimination targets. This project will use statistical and mathematical modelling to inform real world health economic evaluations determine the most cost-effective response. This will inform health policy in Australia and globally.
Long-term Implications And Outcomes Of Anti Hepatitis B Virus (HBV) Treatment In HIV-HBV Co-infection
Funder
National Health and Medical Research Council
Funding Amount
$293,931.00
Summary
Chronic hepatitis B (HBV) infection may cause serious liver disease in some people, including liver failure or liver cancer. Being infected with both HBV and HIV increases the chances of these complications occurring and the rate they develop. The optimal long term management of HIV-HBV co-infection remains unclear; and the effects of antiretroviral therapy on liver disease progression outcome is unknown in the setting of HIV-HBV co-infection.
Understanding The Biological Mechanisms Involved In Treatment Free Remission Of Chronic Myeloid Leukaemia
Funder
National Health and Medical Research Council
Funding Amount
$318,768.00
Summary
Most patients with chronic myeloid leukaemia achieve excellent responses to therapy but need therapy for life. We have pioneered the concept that some patients can cease their therapy and not relapse (treatment free remission –TFR). By studying the immune system, the leukaemic stem cells and the bone marrow environment, we will determine why TFR is possible for some, but not all patients. This holds the key to improving the rate of TFR, thus moving the CML goal from disease control to cure.
Investigation Of Dendritic Cell Activation And Function In A Murine Model Of Plasmodium And Schistosoma Co-infection
Funder
National Health and Medical Research Council
Funding Amount
$358,938.00
Summary
Malaria is responsible for over 2 million deaths annually, mainly in sub-Saharan Africa. Importantly, around 1 billion people in malaria endemic areas are infected with parasitic worms, thus malaria and worm co-infections frequently occur. This project will investigate how malaria and worm parasites interact to influence the immune response and clinical outcomes of each other in a mouse infection model. This will provide new strategies for the design of effective treatments in co-endemic areas.
The Identification Of Thoracic Targets For Prevention And Intervention In Bronchopulmonary Dysplasia
Funder
National Health and Medical Research Council
Funding Amount
$316,449.00
Summary
The persistence of breathing problems from infancy to later life is a complication of premature birth with lifelong consequences. Breathing problems often occur together with lung disease, but prematurity can also affect heart and blood vessel development, and weakness of the main breathing muscle. We will find out how much the heart, lungs and diaphragm contribute to breathing problems in babies; helping us to better predict, diagnose and treat severe breathing problems in babies born preterm.