New multi-scale seed dispersal models for improved regional weed management. This project will exploit recent advances in ecological and atmospheric modelling with the aim to build improved models of seed dispersal across landscapes to anticipate weed spread. Damaging invasive plants are rapidly transforming landscapes and altering ecosystem function worldwide. The speed and direction of weed spread determines the success or failure of costly containment and control actions, however we lack the ....New multi-scale seed dispersal models for improved regional weed management. This project will exploit recent advances in ecological and atmospheric modelling with the aim to build improved models of seed dispersal across landscapes to anticipate weed spread. Damaging invasive plants are rapidly transforming landscapes and altering ecosystem function worldwide. The speed and direction of weed spread determines the success or failure of costly containment and control actions, however we lack the ability to adequately predict spread. New models that combine micrometeorological measurements, within-canopy turbulence and topographic variation in wind flows will be designed to better predict where dispersal will occur. In this project, these improved predictions are planned to be combined with decision models to direct the management of invasive species across entire landscapes.Read moreRead less
Mitigating extreme water supply contamination in bushfire burned catchments. This project involves Melbourne Water, the Department of Environment and Primary Industries, and East Gippsland Water in developing tools to evaluate mitigation options that will protect our water supplies and increase the resilience of Australian communities to bushfire. Major bushfires in south-east Australia in 2003, 2007, 2009 and 2013 were followed by storms that triggered extreme soil erosion events in catchments, ....Mitigating extreme water supply contamination in bushfire burned catchments. This project involves Melbourne Water, the Department of Environment and Primary Industries, and East Gippsland Water in developing tools to evaluate mitigation options that will protect our water supplies and increase the resilience of Australian communities to bushfire. Major bushfires in south-east Australia in 2003, 2007, 2009 and 2013 were followed by storms that triggered extreme soil erosion events in catchments, contaminating water supplies and damaging critical infrastructure. The capacity to mitigate the risk of interruption to the water supplies of our cities and towns in a more fire-prone future is currently limited by our knowledge of where, why, and how often these post-fire contamination events will occur. This project aims to address these knowledge gaps.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE140101611
Funder
Australian Research Council
Funding Amount
$379,040.00
Summary
Snow, shrub and climate feedbacks: impacts of shrub expansion in the Australian alpine zone. This project aims to understand the mechanisms promoting shrub expansion in alpine areas and the consequences of a shrub-dominated landscape in terms of shrubs as hydrological mediators and as biodiversity and ecosystem modifiers. Some shrub species trap wind-blown snow, thereby facilitating seedling survival through soil insulation and increases to meltwater. However, if adaptive and plastic responses t ....Snow, shrub and climate feedbacks: impacts of shrub expansion in the Australian alpine zone. This project aims to understand the mechanisms promoting shrub expansion in alpine areas and the consequences of a shrub-dominated landscape in terms of shrubs as hydrological mediators and as biodiversity and ecosystem modifiers. Some shrub species trap wind-blown snow, thereby facilitating seedling survival through soil insulation and increases to meltwater. However, if adaptive and plastic responses to climate change allows, shrub expansion will have significant negative impacts on alpine biodiversity and ecosystem function. This project will tease apart the interacting effects of snow, recruitment and adaptation to provide models of shrub increase and determine how shrubs modify alpine ecosystem processes and upper catchment hydrology.Read moreRead less
New High-risk Variants For Colorectal Cancer: The Post-GWAS Era
Funder
National Health and Medical Research Council
Funding Amount
$710,105.00
Summary
Our aim is to discover new genes that greatly increase bowel cancer risk. If we can identify these carriers we may be able to prevent them getting cancer. By studying DNA related to bowel cancer, using a novel family design, we will identify families most likely to carry the new genes. We will focus genetic testing, using new techniques, to look for mutations in these prioritised families. Identified mutations will be tested in a 3,500 bowel cancer cases to see how important they are.
Suppression Of NADPH Oxidase-derived Oxidative Stress By Anti-sense Probes And HDL In Human Vascular Endothelium
Funder
National Health and Medical Research Council
Funding Amount
$455,250.00
Summary
In Australia, coronary heart disease (CHD) causing heart attacks remains the largest cause of death, claiming a staggering 28,000 lives a year. Oxidative stress, resulting from increased production of oxygen free radicals in arteries, is an important cause of CHD, heart attacks and strokes. We seek to understand how such oxyradicals are produced in the key cells that form the lining of all arteries, known as the vascular endothelium. By using novel DNA-type molecules (known as anti-sense) develo ....In Australia, coronary heart disease (CHD) causing heart attacks remains the largest cause of death, claiming a staggering 28,000 lives a year. Oxidative stress, resulting from increased production of oxygen free radicals in arteries, is an important cause of CHD, heart attacks and strokes. We seek to understand how such oxyradicals are produced in the key cells that form the lining of all arteries, known as the vascular endothelium. By using novel DNA-type molecules (known as anti-sense) developed in our laboratory, which block a particular gene causing oxidative stress, we will determine whether this gene is responsible for the formation of oxyradicals in human and mouse cells grown in culture. In addition, we will explore whether this gene is turned on by factors known to be involved in CHD. Finally, we will also investigate whether the good cholesterol known as HDL can act to prevent oxidative stress in human cells, as we discovered it appears to do in living arteries in vivo. If we find it has the same protective effect in endothelium, we will determine how it does this, and which component proteins of the HDL particle are important. This might suggest new treatments to prevent acute events leading to heart attack and stroke, and possibly new applications where damage appears to result from acute oxidative stress, such as in the brain soon after a stroke has occurred. We also have a plan to develop antisense drugs that will target the important gene specifically in the affected endothelium. In addition, we have other specific new drugs that will block this system in arteries. Simultaneously we will be testing the role of this gene in mouse and rabbit models of artery disease, for both our types of drugs might provide valuable new therapeutic agents to target the underlying cause of CHD and not just its symptoms as current drugs do.Read moreRead less
The origin of (dark) matter. This project aims to discover the origin and nature of dark matter and why the Universe contains more matter than antimatter – two important unresolved problems in particle physics and cosmology. These questions cannot be resolved within the framework of the particle physics Standard Model, and thus provide concrete evidence that new elementary particle physics remains to be uncovered. This project aims to explore the origin of dark matter, new mechanisms for creatin ....The origin of (dark) matter. This project aims to discover the origin and nature of dark matter and why the Universe contains more matter than antimatter – two important unresolved problems in particle physics and cosmology. These questions cannot be resolved within the framework of the particle physics Standard Model, and thus provide concrete evidence that new elementary particle physics remains to be uncovered. This project aims to explore the origin of dark matter, new mechanisms for creating a matter-antimatter asymmetry, and the possibility that dark and ordinary matter share a common origin. This project could address humanity's deep need to understand the nature of the universe and our origins.Read moreRead less
Frontiers in particle and astroparticle physics. This project will address fundamental questions about our universe, drawing on new experimental data at the cosmic and energy frontiers: what is the cosmological dark matter; why does the universe contain more matter than antimatter; what new surprises may be revealed? The answers will provide a guide to develop fundamental theories of nature.
Discovery Early Career Researcher Award - Grant ID: DE190100003
Funder
Australian Research Council
Funding Amount
$419,113.00
Summary
Aliens in the alps: predicting invasions and protecting native species. This project aims to investigate how warming and alien species invasions impact on Australia’s alpine ecosystems. Using a combination of methods from across the natural and physical sciences, this project endeavours to generate new knowledge on alpine biodiversity and the ability of native and alien species to cope with the pressures of climate warming and decreasing snow fall. Expected outcomes of this project include impro ....Aliens in the alps: predicting invasions and protecting native species. This project aims to investigate how warming and alien species invasions impact on Australia’s alpine ecosystems. Using a combination of methods from across the natural and physical sciences, this project endeavours to generate new knowledge on alpine biodiversity and the ability of native and alien species to cope with the pressures of climate warming and decreasing snow fall. Expected outcomes of this project include improved accuracy and precision in predicting the impacts of environmental change providing benefits to conservation planning and protection of the Australian Alps.Read moreRead less
How does orography enhance precipitation in Australian wintertime storms? This project aims to employ targeted field observations, numerical simulations and new satellite capabilities to identify the dynamical and microphysical mechanisms that enhance and redistribute precipitation across the alpine regions of south eastern Australia and Tasmania. These observations will be used to evaluate operational numerical weather simulations specifically focusing on quantitative precipitation forecasts an ....How does orography enhance precipitation in Australian wintertime storms? This project aims to employ targeted field observations, numerical simulations and new satellite capabilities to identify the dynamical and microphysical mechanisms that enhance and redistribute precipitation across the alpine regions of south eastern Australia and Tasmania. These observations will be used to evaluate operational numerical weather simulations specifically focusing on quantitative precipitation forecasts and estimates. The observations will also be used to extend known biases in the national gridded precipitation analysis that are a result of the complex mountain terrain. This identification of the physical processes that enhance and redistribute precipitation over the alpine regions across south east Australia and Tasmania will lead to better precipitation estimates and forecasts and better water management.Read moreRead less