Identifying Rare Genetic Variants Conferring Susceptibility To Multiple Sclerosis
Funder
National Health and Medical Research Council
Funding Amount
$293,898.00
Summary
Recently there has been success in identifying common genetic variants that confer susceptibility to multiple sclerosis. The variants that have been discovered so far have modest effects on risk of disease, and only explain a small proportion of familial aggregation of disease. In this study we aim to identify rarer genetic variants that have stronger effects on risk of disease, using new statistical methods and new methods to sequence very large amounts of DNA.
The development of homogeneous catalytic processes for the manufacture of new chemical products derivable from Australia's resources. The research proposed is deliberately aimed at exploiting opportunities that will arise as a result of changes that are taking place in the global petrochemical industry. It is almost certain that Australia will take part in these changes through the utilisation of its gas and coal reserves and abundant biomass. Early advances in the processes that are presented a ....The development of homogeneous catalytic processes for the manufacture of new chemical products derivable from Australia's resources. The research proposed is deliberately aimed at exploiting opportunities that will arise as a result of changes that are taking place in the global petrochemical industry. It is almost certain that Australia will take part in these changes through the utilisation of its gas and coal reserves and abundant biomass. Early advances in the processes that are presented above will allow Australian industries to benefit from these changes, and will allow significant value-adding to Australia's resources.Read moreRead less
Cosmic powerhouses: The birth, death, and legacy of black hole jets. This project targets relativistic jets powered by supermassive black holes - the most powerful systems in the Universe. Theoretically, the enormous energies released have a profound influence on how galaxies evolve; empirically, observations reveal signatures of their impact across cosmic time. However, fundamental questions remain about how these jets are triggered and what impact they have on galaxies. The project will addres ....Cosmic powerhouses: The birth, death, and legacy of black hole jets. This project targets relativistic jets powered by supermassive black holes - the most powerful systems in the Universe. Theoretically, the enormous energies released have a profound influence on how galaxies evolve; empirically, observations reveal signatures of their impact across cosmic time. However, fundamental questions remain about how these jets are triggered and what impact they have on galaxies. The project will address these questions using novel supercomputer models of black hole jets in realistic cosmological environments, then confront these predictions with new data from Square Kilometre Array (SKA) pathfinding radio telescopes. This will substantially enhance Australia’s leadership capacity in a strategically important area.Read moreRead less
Carbon in - carbon out: can carbon inputs keep up with losses in peatland? This project aims to quantify the current and predict the future carbon balance of a high altitude, carbon-dense ecosystem, namely sub-alpine grassy peatland, by measuring how environmental variables including experimental warming control the fluxes of carbon and water into and out of the system. In this way, this project will produce new knowledge on the susceptibility of high-altitude peaty soils to climate change. Expe ....Carbon in - carbon out: can carbon inputs keep up with losses in peatland? This project aims to quantify the current and predict the future carbon balance of a high altitude, carbon-dense ecosystem, namely sub-alpine grassy peatland, by measuring how environmental variables including experimental warming control the fluxes of carbon and water into and out of the system. In this way, this project will produce new knowledge on the susceptibility of high-altitude peaty soils to climate change. Expected outcomes include an enhanced ability to predict future carbon accumulation rates and the resilience of the vital water-storage and filtration services provided by these systems. This project will enhance outputs from new infrastructure and assist planning for future flood and drought management across SE Australia.Read moreRead less
How does orography enhance precipitation in Australian wintertime storms? This project aims to employ targeted field observations, numerical simulations and new satellite capabilities to identify the dynamical and microphysical mechanisms that enhance and redistribute precipitation across the alpine regions of south eastern Australia and Tasmania. These observations will be used to evaluate operational numerical weather simulations specifically focusing on quantitative precipitation forecasts an ....How does orography enhance precipitation in Australian wintertime storms? This project aims to employ targeted field observations, numerical simulations and new satellite capabilities to identify the dynamical and microphysical mechanisms that enhance and redistribute precipitation across the alpine regions of south eastern Australia and Tasmania. These observations will be used to evaluate operational numerical weather simulations specifically focusing on quantitative precipitation forecasts and estimates. The observations will also be used to extend known biases in the national gridded precipitation analysis that are a result of the complex mountain terrain. This identification of the physical processes that enhance and redistribute precipitation over the alpine regions across south east Australia and Tasmania will lead to better precipitation estimates and forecasts and better water management.Read moreRead less
Upgrading of light gas-to-liquid products to fuels and chemicals. The conversion of natural gas to liquid fuels (gasoline and diesel) is seen as an important alternative to crude oil refining in Australia, and a new industry based around this is likely to emerge in the coming years. This project aims to develop methods by which some of the less valuable by-products can be upgraded to fuels and chemicals.
Green sample preparation technologies for analytical chemistry. This project opens new directions for the sample preparation of small molecules, nanoparticles and bacterial cells prior to analysis and will reduce pollution from chemical laboratories. The proposed 'green' analytical chemistry techniques will strengthen the position of Australia as a world-leader in separation science.
Perceiving and tracking moving objects. Processing and tracking moving objects poses challenges for human perception. To succeed, visual processing must accumulate analyses of the object from its different positions. Perceptual experiments will reveal human limits and yield insights into the underlying mechanisms, providing a basis for understanding object tracking in tasks like driving.
Building Central Asia: Linking the Growth of Asia to its Exhumation. The consumption of the Tethys Ocean and the associated collision of Gondwana-derived terranes with Eurasia resulted in the uplift of the highest mountain belt on Earth: the Himalayas. However, stresses from this collision zone propagated far into the Eurasian interior by reactivating faults and creating mountain belts along these fault zones. This project aims to map and model how and when fault (re)activation occurred by integ ....Building Central Asia: Linking the Growth of Asia to its Exhumation. The consumption of the Tethys Ocean and the associated collision of Gondwana-derived terranes with Eurasia resulted in the uplift of the highest mountain belt on Earth: the Himalayas. However, stresses from this collision zone propagated far into the Eurasian interior by reactivating faults and creating mountain belts along these fault zones. This project aims to map and model how and when fault (re)activation occurred by integrating multi-method thermochronological and structural data on major Meso-Cenozoic Central Asian fault systems. The resulting time-integrated tectonic model will aid in the understanding of the India-Eurasia collision, the building of the mountainous Central Asian landscape and its influence on the Asian climate.Read moreRead less
How feedback can impair recognition judgments and undermine border security, criminal investigations, educational testing, and medical screening. If a customs officer learns that they have missed an explosive device while screening luggage, will this affect their judgment? In many scenarios, a person receives feedback about their recognition memory performance and has to try again without having another chance to study the material. Almost no research has examined the effects of feedback on reco ....How feedback can impair recognition judgments and undermine border security, criminal investigations, educational testing, and medical screening. If a customs officer learns that they have missed an explosive device while screening luggage, will this affect their judgment? In many scenarios, a person receives feedback about their recognition memory performance and has to try again without having another chance to study the material. Almost no research has examined the effects of feedback on recognition in the absence of opportunity for further study. This is problematic because many vitally important recognition decisions lack such opportunity. Using various scenarios (face recognition, security screening, multiple-choice testing, and medical screening) this project will demonstrate that feedback affects recognition performance differently depending on the nature of the recognition decision.Read moreRead less