Development Of Specific Modulators Of Voltage-gated Sodium Channels
Funder
National Health and Medical Research Council
Funding Amount
$384,479.00
Summary
This project will identify novel modulators of voltage-gated sodium (NaV) channels, a type of sodium-conducting integral membrane proteins, which play a central role in neuronal, muscular, and cardiac function. These modulators will be characterized in order to understand how they modify channel function and to aid their development as analgesics for the treatment of chronic pain.
Analysis And Development Of Medicinal Herbs For The Prevention And Management Of Cardiovascular Disease
Funder
National Health and Medical Research Council
Funding Amount
$358,500.00
Summary
Although medicinal herbs are widely used in the community for the prevention and management of cardiovascular disease, to date no systemic, effective methods are available to assess the physiological effects of these substances. This project will employ advanced bio-cellular and molecular technologies to develop (i) screening procedures, (ii) standardised chemical analyses and (iii) bioassays to allow efficient assessment of new herbal pharmaceuticals in relation to possible cardiovascular activ ....Although medicinal herbs are widely used in the community for the prevention and management of cardiovascular disease, to date no systemic, effective methods are available to assess the physiological effects of these substances. This project will employ advanced bio-cellular and molecular technologies to develop (i) screening procedures, (ii) standardised chemical analyses and (iii) bioassays to allow efficient assessment of new herbal pharmaceuticals in relation to possible cardiovascular activities, side effects, purity and quality.Read moreRead less
Metabolomic Analysis And Membrane Transport Proteins In The Malaria Parasite
Funder
National Health and Medical Research Council
Funding Amount
$368,875.00
Summary
The malaria parasite is a single celled organism which invades the red blood cells of those it infects. There is no vaccine and the parasite is becoming increasingly resistant to the drugs that we have available. There is therefore an urgent need for new antimalarial strategies. Research in this area has been helped by the sequencing of the genome of the parasite. However we still don t know what most of the genes in the parasite do, and it is not a straightforward matter to find out. One of the ....The malaria parasite is a single celled organism which invades the red blood cells of those it infects. There is no vaccine and the parasite is becoming increasingly resistant to the drugs that we have available. There is therefore an urgent need for new antimalarial strategies. Research in this area has been helped by the sequencing of the genome of the parasite. However we still don t know what most of the genes in the parasite do, and it is not a straightforward matter to find out. One of the things hampering us in our efforts to develop new antimalarial drugs is our relatively poor understanding of the sorts of biochemical pathways that the parasite relies on to support its high rate of growth and replication inside the red blood cell, as well the biochemical mechanisms that enable it to becomes drug-resistant. In this study we will use a range of modern analytical techniques to carry out the first detailed survey of the biochemical composition - the so-called metabolome - of the parasite. We will investigate how this changes in response to nutrient deprivation, in response to mutations in genes which play a key role in antimalarial drug resistance and in response to changes in the expression of genes encoding proteins which we believe to be involved in the uptake of nutrients by the parasite. This project will provide us with a wealth of new information about the biochemical make-up of the parasite, and it will provide new insights into the biochemical pathways that are operating and which might be targeted with new drugs. The work is likely to provide new insights into mechanisms of antimalarial drug resistance. It will also form the basis for a strategy that is likely to be extremely useful in helping us to ascribe function to the many genes involved in the biochemistry of this important human pathogen.Read moreRead less
The separation of carbon dioxide from industrial sources using nanoporous carbon. Carbon nanotubes and nanoporous carbon membranes offer the possibility of low cost energy efficient separations of gas mixtures. Possible applications include the purification of greenhouse gases for sequestration and the purification of hydrogen from reformer gas for use in a hydrogen energy economy. The proposed project involves the development of mathematical models and computer simulations to understand and ....The separation of carbon dioxide from industrial sources using nanoporous carbon. Carbon nanotubes and nanoporous carbon membranes offer the possibility of low cost energy efficient separations of gas mixtures. Possible applications include the purification of greenhouse gases for sequestration and the purification of hydrogen from reformer gas for use in a hydrogen energy economy. The proposed project involves the development of mathematical models and computer simulations to understand and optimise the nanoporous structure for different gas separations, and experimental research to produce the carbon nanoporous materials and determine their effectiveness of gas separation.Read moreRead less
The conversion of remote location natural gas to fuels and chemicals. The objectives of the research programme will be to develop novel science, engineering and technology that will allow cost efficient conversion of remote gas reserves to liquid fuels and/or chemicals with minimal greenhouse gas emissions. The significance of the proposal rests in the fact that Australia has large remote location gas fields that cannot be exploited but faces, within ten years, trillion dollars a year balance of ....The conversion of remote location natural gas to fuels and chemicals. The objectives of the research programme will be to develop novel science, engineering and technology that will allow cost efficient conversion of remote gas reserves to liquid fuels and/or chemicals with minimal greenhouse gas emissions. The significance of the proposal rests in the fact that Australia has large remote location gas fields that cannot be exploited but faces, within ten years, trillion dollars a year balance of payments deficits due to a shortgae of liquid fuels. The development of new processes for gas to liquids conversion and new technology for existing processes is the essential aim of the proposed research.Read moreRead less