Identification Of Glaucoma Susceptibility Variants By Exome Sequencing In Extended Pedigrees Showing Prior Evidence Of Gene Segregation.
Funder
National Health and Medical Research Council
Funding Amount
$694,002.00
Summary
Primary open angle glaucoma is a chronic eye disease and one of the leading causes of visual impairment and blindness worldwide. This study will use cutting-edge genetic methods to look at the entire coding component of the human genome (exome) in 271 individuals from large glaucoma families. Our previous studies have shown that these families carry genetic variants that increase disease risk. In this investigation we aim to identify these genes, with the hope they may offer novel targets for tr ....Primary open angle glaucoma is a chronic eye disease and one of the leading causes of visual impairment and blindness worldwide. This study will use cutting-edge genetic methods to look at the entire coding component of the human genome (exome) in 271 individuals from large glaucoma families. Our previous studies have shown that these families carry genetic variants that increase disease risk. In this investigation we aim to identify these genes, with the hope they may offer novel targets for treatment or diagnosis.Read moreRead less
How does orography enhance precipitation in Australian wintertime storms? This project aims to employ targeted field observations, numerical simulations and new satellite capabilities to identify the dynamical and microphysical mechanisms that enhance and redistribute precipitation across the alpine regions of south eastern Australia and Tasmania. These observations will be used to evaluate operational numerical weather simulations specifically focusing on quantitative precipitation forecasts an ....How does orography enhance precipitation in Australian wintertime storms? This project aims to employ targeted field observations, numerical simulations and new satellite capabilities to identify the dynamical and microphysical mechanisms that enhance and redistribute precipitation across the alpine regions of south eastern Australia and Tasmania. These observations will be used to evaluate operational numerical weather simulations specifically focusing on quantitative precipitation forecasts and estimates. The observations will also be used to extend known biases in the national gridded precipitation analysis that are a result of the complex mountain terrain. This identification of the physical processes that enhance and redistribute precipitation over the alpine regions across south east Australia and Tasmania will lead to better precipitation estimates and forecasts and better water management.Read moreRead less
Precipitation in wintertime storms across southeast Australia, Tasmania and the Southern Ocean. The pristine conditions and strong wind-shear over the Southern Ocean affect the formation of precipitation in clouds over the region, which is vital to the water supply of southeastern Australia and Tasmania. This project will evaluate and improve the ability to simulate this precipitation, which will lead to better water resource management.