Clonal Evolution In Myelodysplasia And Acute Myeloid Leukaemia Following Azacitidine
Funder
National Health and Medical Research Council
Funding Amount
$853,005.00
Summary
The myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML) represent a spectrum of clinically heterogeneous malignancies that remain incurable in the vast majority of patients. Whilst the DNA mutations underpinning the initiation/maintenance of these malignancies are largely known we have little insight into how these mutations alter response to therapy. Using a range of sophisticated cutting edge technologies we will study how these DNA mutations evolve over the course of treatment.
New multi-scale seed dispersal models for improved regional weed management. This project will exploit recent advances in ecological and atmospheric modelling with the aim to build improved models of seed dispersal across landscapes to anticipate weed spread. Damaging invasive plants are rapidly transforming landscapes and altering ecosystem function worldwide. The speed and direction of weed spread determines the success or failure of costly containment and control actions, however we lack the ....New multi-scale seed dispersal models for improved regional weed management. This project will exploit recent advances in ecological and atmospheric modelling with the aim to build improved models of seed dispersal across landscapes to anticipate weed spread. Damaging invasive plants are rapidly transforming landscapes and altering ecosystem function worldwide. The speed and direction of weed spread determines the success or failure of costly containment and control actions, however we lack the ability to adequately predict spread. New models that combine micrometeorological measurements, within-canopy turbulence and topographic variation in wind flows will be designed to better predict where dispersal will occur. In this project, these improved predictions are planned to be combined with decision models to direct the management of invasive species across entire landscapes.Read moreRead less
A Functional Assay To Classify Genetic Variants In Lynch Syndrome
Funder
National Health and Medical Research Council
Funding Amount
$368,195.00
Summary
At least one person in every 1000 is affected by Lynch syndrome, in which faulty DNA repair machinery causes high rates of cancer. People with Lynch syndrome can have their risk of cancer cut substantially with regular screening. However, we often struggle to understand whether people with 'non-standard' DNA sequences in particular genes actually have Lynch syndrome. This project develops a simple test that will tell clinicians whether a given sequence change relates to Lynch syndrome or not.
Fighting Epidermal Skin Cancers By Targeting Epidermal Clones That Accumulate Mutations
Funder
National Health and Medical Research Council
Funding Amount
$1,149,373.00
Summary
Common skin cancers such as basal and squamous cell carcinomas (BCC and SCC) are by far the most frequent cancer worldwide and require over a million interventions per year in Australia. This project will identify the skin cells that are most susceptible to give rise to cancer if excessively exposed to the sun and explores ways to prevent cancer formation. This will inform on new strategies to prevent new skin cancer development.
Understanding snow gum dieback for effective and integrated management. The project leverages recent research and infrastructure investments and our determined and collaborative team as it aims to: 1) assess the future geography of snow gum dieback in the high country and identify priority locations for pro-active management, 2) quantify the impact of snow gums on high country water and carbon budgets and thus the socio- economic and biodiversity values, and 3) determine options for mitigation. ....Understanding snow gum dieback for effective and integrated management. The project leverages recent research and infrastructure investments and our determined and collaborative team as it aims to: 1) assess the future geography of snow gum dieback in the high country and identify priority locations for pro-active management, 2) quantify the impact of snow gums on high country water and carbon budgets and thus the socio- economic and biodiversity values, and 3) determine options for mitigation. Dieback of our iconic snow gum forests is diminishing the ecological, hydrological and cultural values of the Australian Alps and will impact state and national water-supply and power-generation systems. Our research will inform Alps-wide management efforts designed for long-term success.Read moreRead less
Extracting subtle hints for new phenomena at the Large Hadron Collider. This project aims to investigate the detailed nature of the Higgs theory which underpins the mass of elementary particles. The project aims to increase the understanding of particle interactions in the context of precise measurements of the properties of the Higgs boson that will come out of the experimental program at the large hadron collider. Expected outcomes include the development and application of methods to address ....Extracting subtle hints for new phenomena at the Large Hadron Collider. This project aims to investigate the detailed nature of the Higgs theory which underpins the mass of elementary particles. The project aims to increase the understanding of particle interactions in the context of precise measurements of the properties of the Higgs boson that will come out of the experimental program at the large hadron collider. Expected outcomes include the development and application of methods to address existing gaps in the framework that confronts theory and experiment and to efficiently explore its high dimensionality. The benefits of conducting this research in Australia include the development of intellectual culture and the training of early-career researchers as flexible problem solvers in academia or beyond. Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE230100867
Funder
Australian Research Council
Funding Amount
$367,518.00
Summary
Bridging the accuracy gap: High-precision parton showers for colliders. This project aims at improving the accuracy of parton showers, which are an essential ingredient used in the simulation of high-energy particle collisions. Parton showers generate the large set of particles produced in a collision, in an approximation of the radiation pattern of Quantum Chromodynamics. The low precision of this approximation translates into large uncertainties in critical measurements performed at particle c ....Bridging the accuracy gap: High-precision parton showers for colliders. This project aims at improving the accuracy of parton showers, which are an essential ingredient used in the simulation of high-energy particle collisions. Parton showers generate the large set of particles produced in a collision, in an approximation of the radiation pattern of Quantum Chromodynamics. The low precision of this approximation translates into large uncertainties in critical measurements performed at particle colliders. This project will study novel ways of enhancing the precision of parton showers, and determine accurate estimates of associated uncertainties across all processes under investigation at the Large Hadron Collider. It will be of exceptional importance for the latter's high-precision, high-luminosity program.Read moreRead less
Beautiful strings. This project aims to carry out several key experimental measurements, in tandem with substantial theoretical work, to improve the understanding and physical modelling of processes involving b quarks, also called beauty quarks, which are of intense current interest for experiments across the globe. Key theoretical innovations include novel treatments of electromagnetic corrections, novel theoretical formulations of the dominant physical paradigm of string fragmentation, and opt ....Beautiful strings. This project aims to carry out several key experimental measurements, in tandem with substantial theoretical work, to improve the understanding and physical modelling of processes involving b quarks, also called beauty quarks, which are of intense current interest for experiments across the globe. Key theoretical innovations include novel treatments of electromagnetic corrections, novel theoretical formulations of the dominant physical paradigm of string fragmentation, and optimisations of key associated algorithms to enable new applications of broad relevance. Experimental measurements will be carried out to validate the new theoretical developments and use them to minimise theoretical uncertainties.Read moreRead less