Integrating Immunity And Genetics In Follicular Lymphoma To Establish A Prognostic Score Fit For The Modern Era
Funder
National Health and Medical Research Council
Funding Amount
$1,377,174.00
Summary
Follicular lymphoma (FL) is divided into early and advanced stages. Early stage FL is frequently cured, but there is no way to identify who will be cured and who won't. By contrast advanced stage FL is incurable. Our unique access to well-annotated clinical trial and population based cohorts allows us to perform a detailed biological comparison of early and advanced FL, to gain a deeper understanding of the impediments to eradicating the disease, and to predict outcome to conventional therapy.
Discovery Early Career Researcher Award - Grant ID: DE180101395
Funder
Australian Research Council
Funding Amount
$365,058.00
Summary
Effect of disease on reproduction plasticity and evolution in amphibians. The project aims to explore the impact of disease on reproductive success in amphibians by utilizing a holistic approach of both lab and field techniques to understand ecological mechanisms for resilience of wildlife to emerging diseases. The project will explore reproductive effort as a population persistence mechanism of declining species. This should advance knowledge of both reproductive plasticity and evolutionary ada ....Effect of disease on reproduction plasticity and evolution in amphibians. The project aims to explore the impact of disease on reproductive success in amphibians by utilizing a holistic approach of both lab and field techniques to understand ecological mechanisms for resilience of wildlife to emerging diseases. The project will explore reproductive effort as a population persistence mechanism of declining species. This should advance knowledge of both reproductive plasticity and evolutionary adaptation in the face of disease. The expected outcomes include developing targeted approaches for conservation agencies.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE240100044
Funder
Australian Research Council
Funding Amount
$860,000.00
Summary
Cryogenic Experimental Laboratory for Low-background Australian Research. This project aims to build an open-access cryogenic facility in the only deep-underground physics laboratory in the southern hemisphere. This facility, called the Cryogenic Experimental Laboratory for Low-background Australian Research (CELLAR), will provide extreme shielding from sources of noise, enabling ultra-precise experiments for fundamental science and emerging applications. The expected outcomes include a deeper u ....Cryogenic Experimental Laboratory for Low-background Australian Research. This project aims to build an open-access cryogenic facility in the only deep-underground physics laboratory in the southern hemisphere. This facility, called the Cryogenic Experimental Laboratory for Low-background Australian Research (CELLAR), will provide extreme shielding from sources of noise, enabling ultra-precise experiments for fundamental science and emerging applications. The expected outcomes include a deeper understanding of astrophysics, alongside technological advances in emerging quantum technologies. CELLAR’s unique capabilities will attract strong international collaborations with multidisciplinary teams, educating the next generation of scientists and advancing the growth of Australian high-technology industries.Read moreRead less
From prediction to adaptation: responding to rapid ecosystem shifts under climate change. Nobody knows exactly how climate change will affect the ecosystems on which we depend for our own existence, though negative impacts are widely predicted. This project integrates mathematical, economic and ecological approaches to learn about the most effective way to spend limited funds for sustaining ecosystems threatened by climate change.
The Management To Optimise Diabetes And MEtabolic Syndrome Risk Reduction Via Nurse-led Intervention (MODERN) Study
Funder
National Health and Medical Research Council
Funding Amount
$1,445,861.00
Summary
There is increasing recognition of society’s responsibility to provide effective and sustainable health care to the entire population and not just selected parts. This practical study will test the impact of a nurse-led, multidisciplinary prevention program to reduce the risk of future cardiovascular events in middle-aged individuals at a high risk of developing cardiovascular disease (CVD) living in regional Australia.
Young Adult Myopia: Genetic And Environmental Associations
Funder
National Health and Medical Research Council
Funding Amount
$809,271.00
Summary
Myopia affects 80% of school leavers in the cities of East Asia, 45% of Asian Australian school leavers and is probably on the rise in European Australian adolescents. Increased levels of education and lack of time outdoors are known to increase the risk of myopia. We will examine 2,000 young adults to find the genes that interact with these risk factors. In addition to confirming when these risk factors are most important, identifying molecular pathways opens the avenue of new treatments.
Identifying Glaucoma Risk Variants In The Norfolk Island Genetic Isolate
Funder
National Health and Medical Research Council
Funding Amount
$658,447.00
Summary
Primary open angle glaucoma is the most common form of glaucoma. In this project we will focus on the identification of functional genetic variants influencing development of this disorder, using a powerful whole exome sequencing approach in a large multigenerational pedigree from the Norfolk Island population isolate. The identification of genes influencing glaucoma development would provide invaluable clues to aid in defining the pathophysiology of this common disease.
The Burden And Risk Factors Of Depressive Disorders In Indigenous Australians: Implications For Early Detection And Prevention
Funder
National Health and Medical Research Council
Funding Amount
$318,768.00
Summary
This Fellowship addresses the high rates of depression amongst Indigenous Australians. The proposed work will quantify the extent to which two major risk factors contribute to the burden of depression in this population and the burden avertable from interventions to modify these risk factors. Findings would inform resource allocation and health service delivery, and in doing so, present opportunities for improvements in the health of Indigenous Australians.
Increasing amphibian immunity to combat disease causing mass extinction. This project aims to increase amphibian survival to combat the devastating chytrid fungus by identifying resistance genes and increasing their frequency in the host population. The project is interdisciplinary and uses targeted genetic manipulation techniques developed for agriculture to improve disease resistance in wildlife for the first time. Expected outcomes include 1) enhanced international collaborations in comparati ....Increasing amphibian immunity to combat disease causing mass extinction. This project aims to increase amphibian survival to combat the devastating chytrid fungus by identifying resistance genes and increasing their frequency in the host population. The project is interdisciplinary and uses targeted genetic manipulation techniques developed for agriculture to improve disease resistance in wildlife for the first time. Expected outcomes include 1) enhanced international collaborations in comparative immunology, 2) a comprehensive understanding of immunity to chytridiomycosis, and 3) disease resistant amphibians. The anticipated benefit is ability to apply the optimal method to improve conservation of wildlife threatened by emerging disease, such as marker assisted selective breeding or genetic engineering.Read moreRead less
Fisheries genomics of snapper in Australia and New Zealand Waters. This industry-driven project aims to assemble a strategic research alliance to generate and apply knowledge to a highly significant fisheries resource. It involves collaboration between the five major state government fisheries agencies in Australia, the New Zealand’s Crown Research Institute for seafood and two Australian labs with leadership in fish genetics and genomics. It expects to generate and integrate genomic, environmen ....Fisheries genomics of snapper in Australia and New Zealand Waters. This industry-driven project aims to assemble a strategic research alliance to generate and apply knowledge to a highly significant fisheries resource. It involves collaboration between the five major state government fisheries agencies in Australia, the New Zealand’s Crown Research Institute for seafood and two Australian labs with leadership in fish genetics and genomics. It expects to generate and integrate genomic, environmental and phenotypic datasets for snapper populations from across vast coastal regions of the two countries. The outcomes should substantially enhance intra- and inter-jurisdictional fisheries management and aquaculture initiatives, providing commercial, social and environmental benefits for many stakeholders.Read moreRead less