Statistical Issues In The Analysis Of Host-viral Genetic Associations
Funder
National Health and Medical Research Council
Funding Amount
$252,849.00
Summary
Viruses such as HIV or Hepatitis B or C may escape detection, and hence control, by the human host immune system through strategic mutations. This project aims to develop statistical methodologies which will facilitate determination of the locations of these strategic mutations and assess the relative impact of different human-host genetic characteristics. Application of the results should benefit the design of tailored vaccines and studies of drug resistance.
Genetics Of DNA Methylation And Its Role In Disease Susecptibility
Funder
National Health and Medical Research Council
Funding Amount
$428,065.00
Summary
DNA methylation is a chemical modification to DNA that sits on the interface of an individual's genetics and environment, which is critical for regulating many cellular processes. There is increasing evidence for a major role of variation in DNA methylation in development of disease and it provides a potential therapeutic target. This research will fill fundamental gaps in our knowledge of the genetic and environmental control of differences in levels of DNA methylation in the population.
A Genome-wide Association Study In 2000 Glaucoma Cases With Matched Controls Using Equimoloar DNA Pools
Funder
National Health and Medical Research Council
Funding Amount
$610,267.00
Summary
Glaucoma is a common cause of loss of vision worldwide but we are unable to predict which people are at high risk of blindness. We aim to discover the genetic risk factors for glaucoma. We will use cutting edge genetic technology to assess the whole genome in thousands of patients with glaucoma. We hope to identify important new glaucoma genes, which could lead to the development of diagnostic tests and treatments which will provide the most cost-efficient ways to prevent glaucoma blindness.