Evolutionary history and impact of adeno-associated viruses in Australia. Recently accrued evidence identifies Australia as an ideal closed-model system in which to elucidate the evolutionary history of a group of non-pathogenic viruses, known as adeno-associated viruses (AAVs). This project aims to trace back the evolutionary history of AAVs for tens of millions of years via molecular fossil imprints left behind by ancient viral invasions of Australian marsupial genomes. Concurrently, the poten ....Evolutionary history and impact of adeno-associated viruses in Australia. Recently accrued evidence identifies Australia as an ideal closed-model system in which to elucidate the evolutionary history of a group of non-pathogenic viruses, known as adeno-associated viruses (AAVs). This project aims to trace back the evolutionary history of AAVs for tens of millions of years via molecular fossil imprints left behind by ancient viral invasions of Australian marsupial genomes. Concurrently, the potential impact that these viral invasions had on the evolutionary development of their ancestral hosts will be investigated. This could facilitate previously unattainable insights into both AAV and marsupial evolution, with broader implications relevant to the advancement of the fields of virology and mammalian evolution.Read moreRead less
Industrial Transformation Training Centres - Grant ID: IC140100003
Funder
Australian Research Council
Funding Amount
$2,389,935.00
Summary
The ARC Research Training Centre for Naval Design and Manufacturing. ARC Training Centre for Transforming Australia's Naval Manufacturing Industry. The aim of the Training Centre is to transform the Australian naval manufacturing industry by creating a new cohort of industry-focused, high-level and broadly skilled engineers and researchers. The resulting network of engineering researchers will enable the industry to more rapidly innovate and solve key problems concerning the efficient design, co ....The ARC Research Training Centre for Naval Design and Manufacturing. ARC Training Centre for Transforming Australia's Naval Manufacturing Industry. The aim of the Training Centre is to transform the Australian naval manufacturing industry by creating a new cohort of industry-focused, high-level and broadly skilled engineers and researchers. The resulting network of engineering researchers will enable the industry to more rapidly innovate and solve key problems concerning the efficient design, construction and sustainment of naval platforms. This industrial transformation will bring significant benefits to Australia as it commences a very ambitious shipbuilding program comprising the design and manufacture of new fleets of submarines, future frigates and patrol boats. The success of these major projects is reliant on developing this cohort of researchers to solve the key research questions.Read moreRead less
Prediction of radiated noise from marine propellers. Underwater noise radiated from marine vessels is a significant problem for research, fishing and military vessels, and is a major source of pollution in the marine environment. The major source contributing to underwater noise is due to the propeller. This work will develop numerical models with experimental validation that can accurately predict the sources of noise generated by marine propellers and acoustic signatures of marine vessels due ....Prediction of radiated noise from marine propellers. Underwater noise radiated from marine vessels is a significant problem for research, fishing and military vessels, and is a major source of pollution in the marine environment. The major source contributing to underwater noise is due to the propeller. This work will develop numerical models with experimental validation that can accurately predict the sources of noise generated by marine propellers and acoustic signatures of marine vessels due to propeller motion. This work has great significance for Australia’s construction and military maritime industries. The technologies developed in this project are also applicable to rotors in other industries such as in aircraft, helicopters and wind turbines.Read moreRead less
Contact Networks, Immunity, and Evolution in Competing Cancer Epidemics. The project aims to evaluate evolutionary interactions between two transmissible cancer epidemics affecting Tasmanian devils and quantify their feedback on infection risk and epidemic behaviour. Using contact tracing and a phylogenetic framework we aim to quantify how tumour lineages evolve with each generation of infection and their effects on susceptibility to infection and disease progression. We expect to reveal the hos ....Contact Networks, Immunity, and Evolution in Competing Cancer Epidemics. The project aims to evaluate evolutionary interactions between two transmissible cancer epidemics affecting Tasmanian devils and quantify their feedback on infection risk and epidemic behaviour. Using contact tracing and a phylogenetic framework we aim to quantify how tumour lineages evolve with each generation of infection and their effects on susceptibility to infection and disease progression. We expect to reveal the host immuno-genetic basis underpinning cancer suppression and the adaptive capacity of populations in response to infectious diseases. This should significantly improve our ability to understand and manage this and other epidemic outbreaks in wildlife, as well as advancing our knowledge in cancer ecology and evolution.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE170101116
Funder
Australian Research Council
Funding Amount
$370,159.00
Summary
Adaptations in Tasmanian devil facial tumour disease. This project aims to understand how defence mechanisms against infectious diseases arise and evolve in nature. Infectious diseases exert strong evolutionary pressures on populations, forcing the development of adaptive strategies to fight the costs of infection. The project aims to determine individual differences in response to infection and how these affect population-scale transmission and evolutionary dynamics under natural and managed sc ....Adaptations in Tasmanian devil facial tumour disease. This project aims to understand how defence mechanisms against infectious diseases arise and evolve in nature. Infectious diseases exert strong evolutionary pressures on populations, forcing the development of adaptive strategies to fight the costs of infection. The project aims to determine individual differences in response to infection and how these affect population-scale transmission and evolutionary dynamics under natural and managed scenarios. This is expected to reveal populations’ adaptive capability and resilience against diseases and the effects of management interventions in controlling disease outbreaks and preventing population declines or extinctions.Read moreRead less