Unravelling The Mechanism Of MHC Class-I Associated Drug Hypersensitivities
Funder
National Health and Medical Research Council
Funding Amount
$566,308.00
Summary
Some drugs cause adverse reactions that are life threatening. We think these reactions are mediated by killer T cells as they are genetically controlled by immune response genes that normally guide immunity to microbes. We will study immune reactions to the drug abacavir, used to treat HIV (AIDS); allopurinol used to prevent gout and carbamazepine, used to treat epilepsy. The study may also help devise better treatments for patients who experience severe forms of these reactions.
Linking evolutionary and molecular biology to safeguard Australian honeybees. Honeybee populations are declining globally but their pollination services are of central importance for food production. This project will study honeybee proteins that influence both fertility and immunity and their effects in vivo. This knowledge is of interest for the bee breeding industry to avoid or combat bee declines in managed Australian bees.
Innovative approaches to understanding and limiting the public health risks of Cryptosporidium and Giardia in animals in Australian catchments. Sophisticated molecular typing and modelling will be used to determine if chlorine-resistant parasites in animals in catchments are responsible for infection in humans. Improved catchment management and risk mitigation strategies will be developed during this project, which will make a substantial contribution to the provision of safe drinking water acro ....Innovative approaches to understanding and limiting the public health risks of Cryptosporidium and Giardia in animals in Australian catchments. Sophisticated molecular typing and modelling will be used to determine if chlorine-resistant parasites in animals in catchments are responsible for infection in humans. Improved catchment management and risk mitigation strategies will be developed during this project, which will make a substantial contribution to the provision of safe drinking water across Australia.Read moreRead less
Troublesome ticks: a new molecular toolkit to investigate zoonotic tick-borne pathogens in Australia. This project will use the latest molecular diagnostic techniques to address unanswered questions about potential tick-transmitted diseases of humans and companion animals in Australia. The study will identify 'hot-spots' for tick-borne pathogens, identify areas of potential risk for humans, and investigate vector-host-pathogen interactions nationwide.
Ecology and transmission of tick-borne disease in Australia. Ecology and transmission of tick-borne disease in Australia. This project aims to determine the bacterial, protozoal and viral biodiversity in wildlife ticks and their native mammal hosts, and provide new information about the biology and transmission dynamics of these microorganisms and their potential to cause disease in wildlife, domesticated animals and humans. Anticipated outcomes are improved diagnostic tests and management proto ....Ecology and transmission of tick-borne disease in Australia. Ecology and transmission of tick-borne disease in Australia. This project aims to determine the bacterial, protozoal and viral biodiversity in wildlife ticks and their native mammal hosts, and provide new information about the biology and transmission dynamics of these microorganisms and their potential to cause disease in wildlife, domesticated animals and humans. Anticipated outcomes are improved diagnostic tests and management protocols for tick-borne disease in Australia.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE120101470
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Using social network models to understand the factors driving parasite transmission in bettong populations. Parasitic diseases pose a significant threat to Australia's biodiversity. This project will apply the use of social networks models to understanding how different parasites are spread through endangered bettong populations.
Discovery Early Career Researcher Award - Grant ID: DE180100635
Funder
Australian Research Council
Funding Amount
$365,058.00
Summary
Demographic distribution models for ecology, conservation & public health. This project aims to advance distribution modelling by developing a new demographic species distribution modelling (DSDM) framework that unites correlative and process-based approaches. This project will develop ecologically realistic models of the distributions of species and diseases, leading to better decision-making in conservation and public health. This will provide significant benefits, such as a better understandi ....Demographic distribution models for ecology, conservation & public health. This project aims to advance distribution modelling by developing a new demographic species distribution modelling (DSDM) framework that unites correlative and process-based approaches. This project will develop ecologically realistic models of the distributions of species and diseases, leading to better decision-making in conservation and public health. This will provide significant benefits, such as a better understanding of where and how to control mosquitoes to reduce malaria transmission in Africa, how best to conserve the vulnerable greater glider in Eastern Australia, and to forecast where and when outbreaks of Ross River virus are likely occur in Victoria.Read moreRead less
Safeguarding honeybees: understanding host-parasite interactions at the level of proteins. Parasites are responsible for dramatic declines of honeybee populations resulting in a loss of pollination services and posing a threat to food production and ecosystem stability. This project will study the honeybee immune system and its interactions with bee parasites on the molecular scale, which will be important to guide future bee breeding.
What drives parasite spread through social networks: lessons from lizards. Australia's biodiversity is continually threatened by new epidemics of local and foreign diseases and parasites. This project will enhance our understanding of how these diseases spread, allowing more effective controls to be developed to protect wildlife species, animal populations and, ultimately, Australian ecosystems.
Impact Of DTP Schedules On The Immunogenicity Of 2 Doses Of 13v-PCV Followed By An Early Booster
Funder
National Health and Medical Research Council
Funding Amount
$2,651,687.00
Summary
This project aims to come up with a vaccination schedule to make pneumococcal vaccines more effective and affordable for Fiji and other developing countries. We will evaluate schedules involving a 2 dose primary series in early infancy with a booster at 9 months of age. We will compare the immune responses to 3 different primary series and 2 booster options. The results of this project will be used to provide advice, at global and country levels, regarding introduction of pneumococcal vaccines.