The Role Of The Cytosolic Pathogen Recognition Molecule Nod1 In Host Responses To Helicobacter Pylori Infection.
Funder
National Health and Medical Research Council
Funding Amount
$82,753.00
Summary
Helicobacter pylori is the causative agent of gastric ulcers and cancer. However, many questions remain unanswered regarding how H. pylori causes gastric disease. We have recently identified the receptor Nod1 as an important factor in the ability of this bacterium to induce inflammation. The major aim of this project is to investigate the role of Nod1 in the innate and adaptive immune responses to this pathogen.
Development Of Innovative Approaches To Manage Insect-transmitted Diseases
Funder
National Health and Medical Research Council
Funding Amount
$4,435,142.00
Summary
This program grant focuses on the development of new methods to control mosquito-borne diseases, including those caused by dengue, Japanese encephalitis, and chikungunya viruses. We are investigating whether the introduction of Wolbachia micro-organisms into mosquitoes can be used to selectively eliminate old mosquitoes and reduce transmission of human pathogens. We will also determine whether Wolbachia have any non-lethal affects on mosquito behaviours such as dispersal and biting activity whic ....This program grant focuses on the development of new methods to control mosquito-borne diseases, including those caused by dengue, Japanese encephalitis, and chikungunya viruses. We are investigating whether the introduction of Wolbachia micro-organisms into mosquitoes can be used to selectively eliminate old mosquitoes and reduce transmission of human pathogens. We will also determine whether Wolbachia have any non-lethal affects on mosquito behaviours such as dispersal and biting activity which determine the level of contact between mosquitoes and humans.Read moreRead less
Bacterial Outer Membrane Vesicles As Immunomodulatory Agents In Helicobacter Pylori Infection
Funder
National Health and Medical Research Council
Funding Amount
$306,510.00
Summary
Chronic inflammation of the stomach is a hallmark of Helicobacter pylori infection, and is a precursor to peptic ulcer disease and cancer. Like many other bacteria, H. pylori sheds spherical blebs from its surface. These blebs bind to stomach cells in vitro and have been found in stomach biopsies of H. pylori-infected subjects. The aims of the work are to investigate the mechanisms whereby H. pylori blebs enter and disseminate within host cells, and how this may contribute to inflammation.