The co-expression of visual pigments in a single photoreceptor: environmental regulation and spectral tuning. The light sensitive cells (photoreceptors) in the vertebrate retina contain filters (oil droplets) and visual pigments (opsins). These structures tune the incoming light and initiate the visual process, respectively. Exciting new research reveals that some vertebrates express more than one opsin within a single photoreceptor. We plan to examine the regulation of single and two co-express ....The co-expression of visual pigments in a single photoreceptor: environmental regulation and spectral tuning. The light sensitive cells (photoreceptors) in the vertebrate retina contain filters (oil droplets) and visual pigments (opsins). These structures tune the incoming light and initiate the visual process, respectively. Exciting new research reveals that some vertebrates express more than one opsin within a single photoreceptor. We plan to examine the regulation of single and two co-expressed opsin genes by manipulating the light environment. We expect to determine the environmental triggers for visual pigment tuning and the effects of co-expression on colour vision.Read moreRead less
Environmental regulation of opsin expression and spectral tuning in the vertebrate retina. Exciting new evidence shows that the vertebrate visual system is extraordinarily plastic and that the colour and brightness of the ambient light regulates both the spatial and temporal expression of visual pigments (opsin) genes and the degree of spectral filtering in the retina. Based on findings that more than one visual pigment can be co-expressed in a single photoreceptor type, we plan to manipulate th ....Environmental regulation of opsin expression and spectral tuning in the vertebrate retina. Exciting new evidence shows that the vertebrate visual system is extraordinarily plastic and that the colour and brightness of the ambient light regulates both the spatial and temporal expression of visual pigments (opsin) genes and the degree of spectral filtering in the retina. Based on findings that more than one visual pigment can be co-expressed in a single photoreceptor type, we plan to manipulate the light environment in order to identify and quantify the effect of different lighting regimes by morphological, spectral and molecular techniques in a concerted effort to understand the regulation of opsin expression.Read moreRead less
The evolution of colour vision in vertebrates. Colour vision plays a crucial role in the lives of many animals including vertebrates. However, very little is known about the origins of colour vision and we aim to fill this gap. Photoreceptors (cone cells) with sensitivities to different colours mediate colour vision (humans possess blue, green and red cones). This study will examine the structure, physiological responses and molecular biology of these cells in the closest living relatives of the ....The evolution of colour vision in vertebrates. Colour vision plays a crucial role in the lives of many animals including vertebrates. However, very little is known about the origins of colour vision and we aim to fill this gap. Photoreceptors (cone cells) with sensitivities to different colours mediate colour vision (humans possess blue, green and red cones). This study will examine the structure, physiological responses and molecular biology of these cells in the closest living relatives of the early vertebrates. The underlying mechanisms for spectral tuning, the genetic rate of evolutionary change and the importance of colour in visual ecology will also be examined.Read moreRead less
The internationalisation of nationalist populism. This project aims to explain the rising international cooperation between nationalist populists in democracies across the world. It expects to generate new knowledge about how and why these forces now work together to oppose common targets such as multilateral institutions, free trade and liberal democracy. Expected outcomes of this project include a sophisticated, evidence-based understanding of the dynamics and effects of contemporary nationali ....The internationalisation of nationalist populism. This project aims to explain the rising international cooperation between nationalist populists in democracies across the world. It expects to generate new knowledge about how and why these forces now work together to oppose common targets such as multilateral institutions, free trade and liberal democracy. Expected outcomes of this project include a sophisticated, evidence-based understanding of the dynamics and effects of contemporary nationalist populist cooperation. Given Australia's commitment to promoting good governance and strong democratic institutions, in addition to the interest overseas nationalist populists have shown in helping likeminded movements in Australia, the project will provide significant benefits for policymakers.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE160100755
Funder
Australian Research Council
Funding Amount
$371,000.00
Summary
Evolution of genome architecture. The project aims to understand how changes to genome architecture over evolutionary time are linked to the diversity of animal morphology. Our genome sequence is arranged into higher order structures that enable coordinated gene expression. The appropriate expression of genes in time and space is necessary to produce the multitude of cell types that make up a multicellular organism. Yet, to date, genome topology is poorly explored, especially between species. Th ....Evolution of genome architecture. The project aims to understand how changes to genome architecture over evolutionary time are linked to the diversity of animal morphology. Our genome sequence is arranged into higher order structures that enable coordinated gene expression. The appropriate expression of genes in time and space is necessary to produce the multitude of cell types that make up a multicellular organism. Yet, to date, genome topology is poorly explored, especially between species. The project involves comparisons of the 3D structure of genomes in divergent species. These findings are expected to inform the underlying principles of gene regulation in animals and species evolution.Read moreRead less
The nexus of law and biology for emerging technologies. At the beginning of the 21st century, biological information has never been more important to law. With the goal of enhancing economic development, the proposed collaboration synthesizes key concepts from jurisprudence and biology. Key research sites of national and international teams- (1) Biologic, Legal Logic; (2) Medical Genetics and Consumers; (3) Feminism, Law, Biology and (4) Biotechnology, Ethics, Environment - explore specific leg ....The nexus of law and biology for emerging technologies. At the beginning of the 21st century, biological information has never been more important to law. With the goal of enhancing economic development, the proposed collaboration synthesizes key concepts from jurisprudence and biology. Key research sites of national and international teams- (1) Biologic, Legal Logic; (2) Medical Genetics and Consumers; (3) Feminism, Law, Biology and (4) Biotechnology, Ethics, Environment - explore specific legal implications of biological information and synergise the intersections. Outcomes and benefits include enhanced communication between jurisprudence and biology, important fora for the disciplines to learn about each other and an internationally recognised national research institute of Law and Biology based in Brisbane.Read moreRead less
Imagining globalisation: The world and nation in Chinese Communist Party ideology. Since the late 1990s, there has been intense interest in globalisation among leaders and theorists of the Chinese Communist Party (CCP). These debates on globalisation represent an important development in the Party's ideology and provide an insight into the way in which it formulates its claim to legitimacy. This project will analyse these debates in the context of the Party's ideological history, and from the pe ....Imagining globalisation: The world and nation in Chinese Communist Party ideology. Since the late 1990s, there has been intense interest in globalisation among leaders and theorists of the Chinese Communist Party (CCP). These debates on globalisation represent an important development in the Party's ideology and provide an insight into the way in which it formulates its claim to legitimacy. This project will analyse these debates in the context of the Party's ideological history, and from the perspective of Western globalisation theory. The project will be of benefit to those institutions and individuals needing to understand changes in China's political elite's perception of the world and the Chinese nation's position within it.Read moreRead less
Structural and neural determinants of stress and strain in human muscle. This project aims to further our understanding of the biomechanical stress and strains experienced by contracting human muscles. Using innovative imaging techniques such as microendoscopy and supersonic shear imaging, we expect to generate new significant evidence on the structural and neural factors that lead to areas of high stress in human muscles. Outcomes of this project include not only a new understanding of muscle d ....Structural and neural determinants of stress and strain in human muscle. This project aims to further our understanding of the biomechanical stress and strains experienced by contracting human muscles. Using innovative imaging techniques such as microendoscopy and supersonic shear imaging, we expect to generate new significant evidence on the structural and neural factors that lead to areas of high stress in human muscles. Outcomes of this project include not only a new understanding of muscle design on multi-scale level, but also of muscle function and adaptation. This should provide significant benefits in better predicting muscle injury and prescribing safe exercise, knowledge that would benefit biomechanical engineers and sport and exercise professionals.Read moreRead less
A common sub-cortical system for human eye and limb control. This project aims to discover how the human brain controls reaching movements via structures and control mechanisms used for rapid eye movements, and for prey capture by lower vertebrates such as fish. Fast and accurate visually-guided movement was crucial for survival long before animals evolved a cerebral cortex, suggesting that basic control systems may be conserved across species. The notion that primitive sub-cortical systems can ....A common sub-cortical system for human eye and limb control. This project aims to discover how the human brain controls reaching movements via structures and control mechanisms used for rapid eye movements, and for prey capture by lower vertebrates such as fish. Fast and accurate visually-guided movement was crucial for survival long before animals evolved a cerebral cortex, suggesting that basic control systems may be conserved across species. The notion that primitive sub-cortical systems can control complex, human limb movements challenges conventional thinking about movement-related brain activity, and has important implications for the design of human-machine interfaces and training protocols in rehabilitation, industry and sport.Read moreRead less
From Periphery to Central: the Politics of China's Central Banking Reform and the Building of a Financial Infrastructure in an Age of Transition. China's rapid economic growth and gradual integration with the international system, in particular the increasingly strong economic links between Australia and China, means Australia now has a big stake in China's financial and economic stability. By explaining the dynamics of China's central banking reform, monetary policy and banking reform since 197 ....From Periphery to Central: the Politics of China's Central Banking Reform and the Building of a Financial Infrastructure in an Age of Transition. China's rapid economic growth and gradual integration with the international system, in particular the increasingly strong economic links between Australia and China, means Australia now has a big stake in China's financial and economic stability. By explaining the dynamics of China's central banking reform, monetary policy and banking reform since 1979, this project will significantly enhance our capacity to interpret monetary policy management and financial development in China, to support our commitment to states in the Asia Pacific region that are dealing with economic reforms and transition, and more importantly, to exert influence on the desired direction of change in China through engagement with the Chinese monetary authority.Read moreRead less