Targeted Development Of AMPK Β2-isoform Allosteric Activators
Funder
National Health and Medical Research Council
Funding Amount
$898,147.00
Summary
Sedentary lifestyles and consumption of high energy foods has led to dramatic increases in the incidence of diseases associated with metabolic dysregulation e.g. type 2 diabetes. An attractive drug target to treat these diseases is AMP-activated protein kinase (AMPK) which functions as a cellular fuel gauge. We have discovered a new drug that crucially activates the form of AMPK found in metabolically active organs. We aim to develop this drug to unlock new therapeutic opportunity.
Pharmacology Of Potential Anti-Tumour Agents: Iron Chelators Of The BpT Class
Funder
National Health and Medical Research Council
Funding Amount
$585,455.00
Summary
Pharmacology of Potential Anti-Tumour Agents: Iron Chelators of the BpT Class Cancer cells have a high iron requirement for DNA synthesis and many clinical trials showed Fe chelators are effective anti-cancer drugs. Their potential to act as anti-tumour agents has been confirmed by the entrance of Triapine into widespread NCI clinical trials. In this NHMRC Renewal, we will perform pharmacological and preclinical studies to promote the development of BpT chelators as novel anti-tumour agents.
Group A Streptococcal Human Challenge Study: Accelerating Vaccine Development
Funder
National Health and Medical Research Council
Funding Amount
$2,018,741.00
Summary
Infection with group A streptococcus (GAS) is a major cause of morbidity and mortality worldwide, including in the Aboriginal population of Australia. Concerted efforts for vaccine development have been hampered by the absence of a suitable animal model. To address this critical knowledge gap we propose to develop a controlled human infection model of GAS infection. This model will provide a direct pathway for the future appraisal of novel GAS vaccines.
Indigenous solutions to global challenges in the Pacific Islands. The global COVID 19 pandemic represents a unique opportunity to understand the nature and potential of Indigenous sustainable development in Pacific Island communities, where Indigenous practices have been central in responses to closed borders and industry downturns. This project proposes to analyse the efficacy and cultural value of new, pandemic-era Indigenous sustainable development initiatives in sustaining island communities ....Indigenous solutions to global challenges in the Pacific Islands. The global COVID 19 pandemic represents a unique opportunity to understand the nature and potential of Indigenous sustainable development in Pacific Island communities, where Indigenous practices have been central in responses to closed borders and industry downturns. This project proposes to analyse the efficacy and cultural value of new, pandemic-era Indigenous sustainable development initiatives in sustaining island communities. It aims to culminate in a novel geographic theory of Indigenous sustainable development, and to identify new opportunities to support the expansion of Indigenous sustainable development. This should better enable the Pacific Islands region to respond to climate change, pandemics and other global challenges.Read moreRead less
Sea-level rise and everyday lives in small island states. This project aims to advance understanding of the impacts of sea-level rise and associated policy responses on the everyday lives of island communities. Focusing on village relocation in Fiji and fortification and land reclamation in the Maldives, the project will analyse people's changing everyday experiences and practices. The project seeks to enable international and interdisciplinary collaborations, and to produce new knowledge on the ....Sea-level rise and everyday lives in small island states. This project aims to advance understanding of the impacts of sea-level rise and associated policy responses on the everyday lives of island communities. Focusing on village relocation in Fiji and fortification and land reclamation in the Maldives, the project will analyse people's changing everyday experiences and practices. The project seeks to enable international and interdisciplinary collaborations, and to produce new knowledge on the opportunities and challenges of diverse policy responses to sea-level rise. The project’s findings will be beneficial for countries facing the threat of sea-level rise, as well as national governments and international agencies that support and fund climate adaptation.Read moreRead less
Centre Of Research Excellence In Medicines Intelligence
Funder
National Health and Medical Research Council
Funding Amount
$2,500,000.00
Summary
The NHMRC Centre of Research Excellence in Medicines Intelligence is a co-ordinated research program that will accelerate the development and translation of evidence on prescribed medicines use and outcomes for regulators and payers. The CRE is perfectly placed to embrace the national ‘call to action’ from the Health Minister's recent announcement to establish Quality Use of Medicine Safety as a National Health Priority.
From Productivism to Multifunctionality? Agri-environmental Governance in Australia and the United Kingdom. This project is concerned with the policy debate surrounding the governance of farming and natural resource management. It addresses the question of whether Australia can combine a liberalised economy with a shift from highly intensive, 'productivist' agriculture towards more sustainable land management and viable rural communities. The research will contribute to an understanding of the c ....From Productivism to Multifunctionality? Agri-environmental Governance in Australia and the United Kingdom. This project is concerned with the policy debate surrounding the governance of farming and natural resource management. It addresses the question of whether Australia can combine a liberalised economy with a shift from highly intensive, 'productivist' agriculture towards more sustainable land management and viable rural communities. The research will contribute to an understanding of the concept of 'multifunctionality', which has policy implications for agriculture, trade and international relations.Read moreRead less
Regulation and Governance of Agricultural Biotechnology: GMOs in Australia and the United Kingdom. Agricultural biotechnology has won Australian government support for its economic development potential but has associated ethical, consumer and environmental risks. The proposed research will contribute to the important task of successfully negotiating agricultural biotechnology futures through a comprehensive analysis of policy and regulatory structures, and stakeholder perceptions of impacts on ....Regulation and Governance of Agricultural Biotechnology: GMOs in Australia and the United Kingdom. Agricultural biotechnology has won Australian government support for its economic development potential but has associated ethical, consumer and environmental risks. The proposed research will contribute to the important task of successfully negotiating agricultural biotechnology futures through a comprehensive analysis of policy and regulatory structures, and stakeholder perceptions of impacts on environmental and economic sustainability. A comparison with the UK provides a valuable point of reference in evaluating policy and regulatory responses. Since the UK is a significant market for Australian produce, the outlook of UK consumers and the regulatory response of the government are highly relevant to Australian policy decisions.Read moreRead less
Transnational seafood commodity chains and the coastal poor in the maritime frontiers of the Asia-Pacific. This research aims to understand the social mechanisms by which access to the benefits of transnational seafood commodity chains in the Asia-Pacific are gained, maintained and controlled. This project will use a conceptual framework that focuses on key social relations of gender, class and ethnicity, and the key societal changes of land-use change, migration and conservation. This project o ....Transnational seafood commodity chains and the coastal poor in the maritime frontiers of the Asia-Pacific. This research aims to understand the social mechanisms by which access to the benefits of transnational seafood commodity chains in the Asia-Pacific are gained, maintained and controlled. This project will use a conceptual framework that focuses on key social relations of gender, class and ethnicity, and the key societal changes of land-use change, migration and conservation. This project offers a novel research framework for a pressing cluster of economic, environmental and social challenges in the Asia-Pacific, and will inform research and policy for poverty reduction, economic development, environmental management and food security. Read moreRead less
An Investigation Of The Involvement Of Clotting Factors In Abdominal Aortic Aneurysm (AAA) Progression Within A Mouse Model
Funder
National Health and Medical Research Council
Funding Amount
$189,401.00
Summary
Early stage weakening of the main abdominal artery is present in ~100,000 Australians and currently has no accepted therapy. Development of drug therapies which limit progression of the weakening process is urgently needed. In this study involvement of the clotting cascade in artery weakening will be investigated. The study have been planned in order to identify new strategies which can be developed as treatments for artery weakening in patients.