Derivation Of Pancreatic Beta Cells From Embryonic Stem Cells
Funder
National Health and Medical Research Council
Funding Amount
$2,968,050.00
Summary
People with type 1 diabetes require regular insulin injections because the organ that normally makes insulin, the pancreas, no longer functions. The goal of this program is to derive human fetal pancreas tissues from embryonic stem cells. Such tissue could be used to replace the missing insulin producing cells in people with type 1 diabetes. The program brings together expertise in ES cell biology at Monash University and the leading diabetes research at the Walter and Eliza Hall Institute.
My research involves the generation of human cell types from of human embryonic stem cells. These normal human cells could potentially be used for transplantation, drug screening and vaccine development.
Understanding The Pathogenesis Of Mitochondrial Disease Using IPS Cells
Funder
National Health and Medical Research Council
Funding Amount
$640,372.00
Summary
Induced pluripotent stem (iPS) cells are stem cells derived from adult skin cells that can be converted into cell types such as neurons. iPS cells offer great promise in understanding and treating inherited disorders. However, there are concerns that the “epigenetic memory” of iPS cells has not been completely erased, which may limit the utility of iPS cells. We will evaluate and validate the use of iPS technology in mouse and human models of inherited disorders affecting energy generation.
Discovery Early Career Researcher Award - Grant ID: DE120101037
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
After the deluge: revisiting displacement and resettlement at the Three Gorges Dam, China. The three Gorges Dam project in China displaced 1.13 million people. This project will investigate what happened to those evicted and draw lessons for the nations and institutions that operationalise the displacement of some 10 million people each year.
Towards better multidimensional well-being measurement. The research will develop enhanced multidimensional measures of well-being and provide guidance that will significantly improve their use and interpretation. It will provide insights that will better inform policies aimed at higher well-being levels.
Characterization Of HOXA-expressing Human Haematopoietic Cells Generated From Embryonic Stem Cells
Funder
National Health and Medical Research Council
Funding Amount
$622,464.00
Summary
Blood stem cell transplants are used for treating a range of human blood disorders such as leukaemias. However, for many patients, suitable donors cannot be found. We are searching for ways in which embryonic stem cells can be turned into blood stem cells in the laboratory to provide a new source of these cells that could then be used to treat patients.
Transcriptional Regulation Of Definitive Hematopoietic Development In Humans
Funder
National Health and Medical Research Council
Funding Amount
$800,036.00
Summary
Blood stem cell transplantation is a vital therapy for patients with leukaemia following chemotherapy or for patients with bone marrow failure. Because many patients lack a donor, there is a need for an alternate source of stem cells, such as human pluripotent stem cells. During development, blood cells are formed from the blood vessel wall, or endothelium. In this project, we will study the regulation of this process in order to more efficiently make human blood cells in the laboratory.
Selective Isolation And In Vivo Properties Of Dopamine Neurons Generated From Embryonic Stem Cells.
Funder
National Health and Medical Research Council
Funding Amount
$505,389.00
Summary
This research aims to develop a procedure that allows for the safe and effective use of stem cells as a therapy for Parkinson’s disease. It is based on the concept that new dopamine neurons, generated from stem cells, can be implanted into the brain of the patients in order to replace those lost to the disease, thereby improving motor function.
Discovery Early Career Researcher Award - Grant ID: DE180100901
Funder
Australian Research Council
Funding Amount
$348,273.00
Summary
Agricultural skill development in India: Assessing acquisition and impact. This project aims to investigate the impact of new agricultural vocational training programs in rural India on processes of skill acquisition and youth livelihood trajectories. As India rapidly expands its capacity for formal skill development in agriculture, this study will be among the first to employ an innovative qualitative longitudinal research design to assess these programs’ ground-level impacts. Expected outcomes ....Agricultural skill development in India: Assessing acquisition and impact. This project aims to investigate the impact of new agricultural vocational training programs in rural India on processes of skill acquisition and youth livelihood trajectories. As India rapidly expands its capacity for formal skill development in agriculture, this study will be among the first to employ an innovative qualitative longitudinal research design to assess these programs’ ground-level impacts. Expected outcomes include deeper understandings of how agricultural skill development occurs in social contexts over an extended period. Research will inform policy in India and other developing countries on how to maximise the social impact of these initiatives. It will also provide insights on how Australia can deepen engagement with India in areas of vocational training.Read moreRead less
Indigenous solutions to global challenges in the Pacific Islands. The global COVID 19 pandemic represents a unique opportunity to understand the nature and potential of Indigenous sustainable development in Pacific Island communities, where Indigenous practices have been central in responses to closed borders and industry downturns. This project proposes to analyse the efficacy and cultural value of new, pandemic-era Indigenous sustainable development initiatives in sustaining island communities ....Indigenous solutions to global challenges in the Pacific Islands. The global COVID 19 pandemic represents a unique opportunity to understand the nature and potential of Indigenous sustainable development in Pacific Island communities, where Indigenous practices have been central in responses to closed borders and industry downturns. This project proposes to analyse the efficacy and cultural value of new, pandemic-era Indigenous sustainable development initiatives in sustaining island communities. It aims to culminate in a novel geographic theory of Indigenous sustainable development, and to identify new opportunities to support the expansion of Indigenous sustainable development. This should better enable the Pacific Islands region to respond to climate change, pandemics and other global challenges.Read moreRead less