Identification of causal variants for complex traits. The aim of this project is to identify causal variants for complex traits in cattle and humans. Although most important traits in agriculture, medicine and evolution are complex traits, very few of the genetic variants affecting these traits are known and this undermines our understanding of how genetic variants affect a trait and practical uses of this knowledge. Huge datasets of individuals with genome sequence and phenotypes and new statis ....Identification of causal variants for complex traits. The aim of this project is to identify causal variants for complex traits in cattle and humans. Although most important traits in agriculture, medicine and evolution are complex traits, very few of the genetic variants affecting these traits are known and this undermines our understanding of how genetic variants affect a trait and practical uses of this knowledge. Huge datasets of individuals with genome sequence and phenotypes and new statistical methods provide the opportunity to close this gap. The outcome will be identification of many genomic variants causing variation in complex traits. This will benefit scientific understanding of complex traits and the ability to predict traits for individuals from their genome sequence.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE210100705
Funder
Australian Research Council
Funding Amount
$462,948.00
Summary
Decoding the enigmatic biology of human gamma-delta T cells. The immune system surveys our body examining molecules that signal whether or not everything is ok. T cells are a central to this and use their receptors to monitor these molecular signals. A specialised subset of T cells known as gamma-delta T cells are critical to detecting infection and cancer, yet their fundamental biology is poorly understood. This project aims to unravel this elusive biology. The aims are to understand 1. The div ....Decoding the enigmatic biology of human gamma-delta T cells. The immune system surveys our body examining molecules that signal whether or not everything is ok. T cells are a central to this and use their receptors to monitor these molecular signals. A specialised subset of T cells known as gamma-delta T cells are critical to detecting infection and cancer, yet their fundamental biology is poorly understood. This project aims to unravel this elusive biology. The aims are to understand 1. The diversity in function between gamma-delta T cell subsets, and 2. The diversity in gamma-delta T cell receptors and the molecules that these receptors detect. This work is essential for understanding gamma-delta T cell immunology which is critical if we ultimately wish to harness this to improve human health.Read moreRead less
Co-designing Innovations in Digital Storytelling with Older Adults. This project aims to investigate how emerging technologies can be leveraged to provide innovative ways for older adults to create and share their life stories to foster social wellbeing. Later life can be a time of considerable change, leaving people feeling disconnected from the people, places, and life events that are important to them. Autobiographical storytelling can help create links with one's past, but little is known ab ....Co-designing Innovations in Digital Storytelling with Older Adults. This project aims to investigate how emerging technologies can be leveraged to provide innovative ways for older adults to create and share their life stories to foster social wellbeing. Later life can be a time of considerable change, leaving people feeling disconnected from the people, places, and life events that are important to them. Autobiographical storytelling can help create links with one's past, but little is known about how technologies such as digital games and virtual reality can be used to enable older adults to share stories about their lives in a way that supports ongoing social interactions. This project is expected to co-design new forms of digital storytelling to improve social wellbeing of older adults. Read moreRead less
A study of China’s south to north water transfer project. This project aims to investigate the motives, processes, and socio-political and hydrological consequences of the South-North Water Transfer (SNWT) in China, the world’s largest inter-basin water network. It connects four major river basins, six provinces, three megacities and over 700 million people. This project will analyse the SNWT's governance regime; its effects on local and regional flows of water, money, people, pollutants, produc ....A study of China’s south to north water transfer project. This project aims to investigate the motives, processes, and socio-political and hydrological consequences of the South-North Water Transfer (SNWT) in China, the world’s largest inter-basin water network. It connects four major river basins, six provinces, three megacities and over 700 million people. This project will analyse the SNWT's governance regime; its effects on local and regional flows of water, money, people, pollutants, production and political authority; and the interactions between these systemic and local changes. This project expects to produce knowledge about the politics of vast technologies, and the management of inter-basin water schemes in Australia and globally.Read moreRead less
(Re)Designing Digital Justice. This project aims to address the challenge of (re)designing novel online court systems by introducing a human-centred design process to the legal process. This project will generate fundamental new knowledge in respect of how to effectively design an inclusive justice system, bridging the gap between the legal system and human-computer interaction. Expected outcomes include how to use technology to implement a more just, efficient, and fair legal system, which is a ....(Re)Designing Digital Justice. This project aims to address the challenge of (re)designing novel online court systems by introducing a human-centred design process to the legal process. This project will generate fundamental new knowledge in respect of how to effectively design an inclusive justice system, bridging the gap between the legal system and human-computer interaction. Expected outcomes include how to use technology to implement a more just, efficient, and fair legal system, which is accessible to all Australians. This should provide significant benefits for both Australian society and the legal system.Read moreRead less
Beyond the resource curse: redistribution and resource-led development. The project aims to improve the sustainability of resource-led development in Australia and worldwide via a novel, multi-scalar framework, co-produced with mining/Indigenous communities that connects local development outcomes with mining global production networks (GPN). It will generate new, community co-authored and policy-engaged knowledge to better attune fiscal, industry and regional policies to tackling the local reso ....Beyond the resource curse: redistribution and resource-led development. The project aims to improve the sustainability of resource-led development in Australia and worldwide via a novel, multi-scalar framework, co-produced with mining/Indigenous communities that connects local development outcomes with mining global production networks (GPN). It will generate new, community co-authored and policy-engaged knowledge to better attune fiscal, industry and regional policies to tackling the local resource curse. Expected outcomes include co-developed GPN theory advances; new policies for sustainable mining locality development; and more engaged mining/Indigenous communities. Significant welfare savings, social coherence, environment amelioration and cultural transformation benefits are expected.Read moreRead less
The drowned: cultural and political geographies. This project aims to reveal and critically analyse the geographies of drowning and the drowned. Drowning is the third most common cause of death worldwide, and a subject of universal interest that is relatively limited in specifically cultural and political geographical research, policy, and debate. The project will be significant by rectifying that gap and investigating shared concerns about drowning’s abiding, widespread, profound effects. The e ....The drowned: cultural and political geographies. This project aims to reveal and critically analyse the geographies of drowning and the drowned. Drowning is the third most common cause of death worldwide, and a subject of universal interest that is relatively limited in specifically cultural and political geographical research, policy, and debate. The project will be significant by rectifying that gap and investigating shared concerns about drowning’s abiding, widespread, profound effects. The expected outcomes will include public debate about drowning and its cultural and political reach and management generated from a book, articles, and blog. Benefits will include new fundamental knowledge and practical insights about how to rethink risks and disasters in rapidly changing environments.Read moreRead less
Pedalling for change: cultural geography for traffic congestion innovation. This project aims to offer new knowledge about why commuter cycling has failed to increase at a time when leisure cycling grows exponentially. The project seeks to provide evidence about what cycling enables people to achieve through analysis of a database of media discourses, policies and most importantly the experiences of cyclists. Expected outcomes include an enhanced understanding of cycling as response to congestio ....Pedalling for change: cultural geography for traffic congestion innovation. This project aims to offer new knowledge about why commuter cycling has failed to increase at a time when leisure cycling grows exponentially. The project seeks to provide evidence about what cycling enables people to achieve through analysis of a database of media discourses, policies and most importantly the experiences of cyclists. Expected outcomes include an enhanced understanding of cycling as response to congestion and improved policy strategies for increasing purposeful cycling in cities including moving the focus from cycling participation rates to cultures of cycling. Australia will benefit from cycling growing as a mode of transport to attenuate traffic congestion in metropolitan centres.Read moreRead less
Integrated Futures for the use of Motorised Mobility Devices. People using Motorised Mobility Devices (MMDs) face increased regulation. A pessimism exists about the future of MMDs because of the lack of evidence and explanation of MMD use in transport decision making. This project aims to fundamentally change knowledge about the everyday meanings and experiences of MMDs. The project seeks to provide comparative, trustworthy and in-depth baseline empirical data about how people who are reliant u ....Integrated Futures for the use of Motorised Mobility Devices. People using Motorised Mobility Devices (MMDs) face increased regulation. A pessimism exists about the future of MMDs because of the lack of evidence and explanation of MMD use in transport decision making. This project aims to fundamentally change knowledge about the everyday meanings and experiences of MMDs. The project seeks to provide comparative, trustworthy and in-depth baseline empirical data about how people who are reliant upon MMDs negotiate the current transport infrastructure. Expected outcomes with our Partner Organisation, Assistive Technology Services Australia, include a database of deliberative strategies. This project will benefit Australia’s urban and regional communities through a better understanding of transport. Read moreRead less
Understanding contested human-plant geographies for urban greening success. Urban greening is vital for sustainable, liveable and climate-adapted cities. However, conflicts over urban greening continue to cause delays and even failure of initiatives. Such disputes, and the diverse socio-cultural relations that drive them, remain poorly understood. In ground-breaking research employing innovative concepts and methods developed by the team, this project aims to generate new knowledge about how peo ....Understanding contested human-plant geographies for urban greening success. Urban greening is vital for sustainable, liveable and climate-adapted cities. However, conflicts over urban greening continue to cause delays and even failure of initiatives. Such disputes, and the diverse socio-cultural relations that drive them, remain poorly understood. In ground-breaking research employing innovative concepts and methods developed by the team, this project aims to generate new knowledge about how people experience urban greening in their everyday lives and how urban greening is contested in three Australian cities. Expected outcomes include new, crucial understandings of key human-plant relationships, facilitated international collaborations, and significant findings for improving urban greening policies and governance.Read moreRead less