Group A Streptococcal Human Challenge Study: Accelerating Vaccine Development
Funder
National Health and Medical Research Council
Funding Amount
$2,018,741.00
Summary
Infection with group A streptococcus (GAS) is a major cause of morbidity and mortality worldwide, including in the Aboriginal population of Australia. Concerted efforts for vaccine development have been hampered by the absence of a suitable animal model. To address this critical knowledge gap we propose to develop a controlled human infection model of GAS infection. This model will provide a direct pathway for the future appraisal of novel GAS vaccines.
Transnational seafood commodity chains and the coastal poor in the maritime frontiers of the Asia-Pacific. This research aims to understand the social mechanisms by which access to the benefits of transnational seafood commodity chains in the Asia-Pacific are gained, maintained and controlled. This project will use a conceptual framework that focuses on key social relations of gender, class and ethnicity, and the key societal changes of land-use change, migration and conservation. This project o ....Transnational seafood commodity chains and the coastal poor in the maritime frontiers of the Asia-Pacific. This research aims to understand the social mechanisms by which access to the benefits of transnational seafood commodity chains in the Asia-Pacific are gained, maintained and controlled. This project will use a conceptual framework that focuses on key social relations of gender, class and ethnicity, and the key societal changes of land-use change, migration and conservation. This project offers a novel research framework for a pressing cluster of economic, environmental and social challenges in the Asia-Pacific, and will inform research and policy for poverty reduction, economic development, environmental management and food security. Read moreRead less
Role Of IGF Binding Protein-3 (IGFBP-3) And IGFBP-5 As Modulators Of Nuclear Hormone Signalling
Funder
National Health and Medical Research Council
Funding Amount
$465,750.00
Summary
The insulin-like growth factors are small proteins involved in the growth of most tissues. Their actions are regulated by binding to larger proteins (known as IGFBPs) in the bloodstream and outside the cell. However, some IGFBPs are also found inside cells, where they seem to carry out other functions. We believe that two of these binding proteins, IGFBP-3 and IGFBP-5, change the way cells respond to vitamin A and vitamin D. These two vitamins are important in cell growth and in the way certain ....The insulin-like growth factors are small proteins involved in the growth of most tissues. Their actions are regulated by binding to larger proteins (known as IGFBPs) in the bloodstream and outside the cell. However, some IGFBPs are also found inside cells, where they seem to carry out other functions. We believe that two of these binding proteins, IGFBP-3 and IGFBP-5, change the way cells respond to vitamin A and vitamin D. These two vitamins are important in cell growth and in the way certain cells perform specialised functions. In test-tube experiments, IGFBP-3 and IGFBP-5 interact directly with the receptors that regulate the effects of these hormones. If the same thing happens inside the cell, IGFBP-3 and IGFBP-5 could change the way these receptors respond to signals from outside the cell. We will investigate what effect these IGFBPs have in living cells and in whole animals and how this may relate to human disease. If we are able to understand how IGFBP-3 and IGFBP-5 affect the way cells respond to vitamin A and D, then we may be able to develop new ways to treat certain human diseases.Read moreRead less
Learning catalysts: improving educational outcomes for disadvantaged children. This project will identify what works to improve educational outcomes for disadvantaged young people. In so doing, this project will contribute to Australia's prosperity and social well-being, and help address problems such as unemployment and homelessness, that arise when a large proportion of young Australians is denied an effective education.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0347122
Funder
Australian Research Council
Funding Amount
$200,000.00
Summary
Australian Women's Archives Project (AWAP). Australian Women's Archives Project aims to enhance infrastructure for researchers in the field of women's and gender history by constructing appropriate data bases and a range of other electronic sources of information, and by improving the preservation and accessibility of records and archives relevant to this prominent and growing field. Project outcomes will include support for the production of cutting edge academic historical works and simultaneo ....Australian Women's Archives Project (AWAP). Australian Women's Archives Project aims to enhance infrastructure for researchers in the field of women's and gender history by constructing appropriate data bases and a range of other electronic sources of information, and by improving the preservation and accessibility of records and archives relevant to this prominent and growing field. Project outcomes will include support for the production of cutting edge academic historical works and simultaneously, the significant contribution of an essential information resource base for Australian women.
The Australian Women's Archives Project employs innovative technologies and adheres to state-of-the-art international standards for electronic management of historical information. The roles of AWAP's Chief Investigators reflect the use of these new forms of information management: CIs both create and utilise the products of each others' collaborative historical research.
Read moreRead less
Identifying effective strategies to grow and sustain a professional early years workforce. The National Early Years Workforce Strategy (2012) identifies the imperative for a larger, more qualified, professional, responsive and collaborative childcare workforce. This need is urgent. By 2014, Commonwealth legislation specifies that all long day-care centres must have a qualified teacher and minimum staff qualification of Certificate III. Yet high turnover, skill loss and failure to meet existing q ....Identifying effective strategies to grow and sustain a professional early years workforce. The National Early Years Workforce Strategy (2012) identifies the imperative for a larger, more qualified, professional, responsive and collaborative childcare workforce. This need is urgent. By 2014, Commonwealth legislation specifies that all long day-care centres must have a qualified teacher and minimum staff qualification of Certificate III. Yet high turnover, skill loss and failure to meet existing qualification standards persist. Nationally, multiple strategies are being implemented to achieve the new qualification standards but there is scant evidence about their effectiveness. This project aims to identify the most effective strategies to reduce loss and increase professional engagement in the early years workforce.Read moreRead less
Sustainable farming in Australia: Market instruments for improved land management. Sustainable farming has become a national priority. As climate change and global economic pressures increase the problems facing rural areas, Australian governments have attempted to combine more sustainable land management with a competitive agricultural sector. Several policy instruments using market incentives have been proposed to manage the competing demands of farm viability and environmental sustainability. ....Sustainable farming in Australia: Market instruments for improved land management. Sustainable farming has become a national priority. As climate change and global economic pressures increase the problems facing rural areas, Australian governments have attempted to combine more sustainable land management with a competitive agricultural sector. Several policy instruments using market incentives have been proposed to manage the competing demands of farm viability and environmental sustainability. This project will examine the responses of beef, dairy and grain farmers to these initiatives and their potential for addressing pressing environmental issues. The research will make a vital contribution to the design of policies for the future of farming, resilient rural communities and an environmentally sustainable Australia.Read moreRead less
Contingent development in regional India: ethnographies of neoliberal globalisation in Gujarat and West Bengal. This project aims to understand the regional impacts of globalisation in India by comparing and contrasting two regional towns and their hinterlands (Anand, Gujarat and Darjeeling, West Bengal). Develop a more comprehensive, localised and regionalised account of the neoliberal globalisation process in India.
Investigating the effectiveness of teacher education for early career teachers in diverse settings: a longitudinal study. This project investigates the effectiveness of teacher education programs in Victoria and Queensland in preparing teachers for the variety of school settings in which they begin their careers. The findings will inform state and national policy, as well as the work of professional regulation authorities and teacher education providers.