Group A Streptococcal Human Challenge Study: Accelerating Vaccine Development
Funder
National Health and Medical Research Council
Funding Amount
$2,018,741.00
Summary
Infection with group A streptococcus (GAS) is a major cause of morbidity and mortality worldwide, including in the Aboriginal population of Australia. Concerted efforts for vaccine development have been hampered by the absence of a suitable animal model. To address this critical knowledge gap we propose to develop a controlled human infection model of GAS infection. This model will provide a direct pathway for the future appraisal of novel GAS vaccines.
Transnational seafood commodity chains and the coastal poor in the maritime frontiers of the Asia-Pacific. This research aims to understand the social mechanisms by which access to the benefits of transnational seafood commodity chains in the Asia-Pacific are gained, maintained and controlled. This project will use a conceptual framework that focuses on key social relations of gender, class and ethnicity, and the key societal changes of land-use change, migration and conservation. This project o ....Transnational seafood commodity chains and the coastal poor in the maritime frontiers of the Asia-Pacific. This research aims to understand the social mechanisms by which access to the benefits of transnational seafood commodity chains in the Asia-Pacific are gained, maintained and controlled. This project will use a conceptual framework that focuses on key social relations of gender, class and ethnicity, and the key societal changes of land-use change, migration and conservation. This project offers a novel research framework for a pressing cluster of economic, environmental and social challenges in the Asia-Pacific, and will inform research and policy for poverty reduction, economic development, environmental management and food security. Read moreRead less
Where migrants go: A study of immigrants' post-arrival moves in Australia . The project aims to establish the geographical and occupational trajectories of different migrant groups after arrival in Australia. Migration within Australia is a key driver of economic, demographic and social change. Recognising the growing diversity of immigrants, including the rapid rise in temporary migration, the project examines post-arrival moves of immigrants by visa type, country of birth and year of arrival. ....Where migrants go: A study of immigrants' post-arrival moves in Australia . The project aims to establish the geographical and occupational trajectories of different migrant groups after arrival in Australia. Migration within Australia is a key driver of economic, demographic and social change. Recognising the growing diversity of immigrants, including the rapid rise in temporary migration, the project examines post-arrival moves of immigrants by visa type, country of birth and year of arrival. It seeks to improve understanding of the incidence, spatial patterns and drivers of migrants’ movement within Australia and the socio-demographic impact on regions and individuals. Such understanding is an essential first step to the formulation of effective immigration and settlement policies and programs.Read moreRead less
Settling well in regional Australia: Experiences of people from refugee backgrounds. Regional humanitarian settlement is a key priority across all levels of government in Australia. This study aims to provide the first longitudinal assessment of the impacts of regional settlement for humanitarian migrants and destination communities. Its innovative, mixed-method and multi-sited approach will generate new knowledge of the opportunities and challenges for sustainable regional settlement. Expected ....Settling well in regional Australia: Experiences of people from refugee backgrounds. Regional humanitarian settlement is a key priority across all levels of government in Australia. This study aims to provide the first longitudinal assessment of the impacts of regional settlement for humanitarian migrants and destination communities. Its innovative, mixed-method and multi-sited approach will generate new knowledge of the opportunities and challenges for sustainable regional settlement. Expected outcomes include enhanced community, organisational and government decision-making capacity. By guiding end-users’ current and future actions, the study has strong potential to support the wellbeing of humanitarian migrants and to contribute to healthy and resilient regional communities.Read moreRead less
Social implications of market-based policy instruments for carbon and water. This project aims to analyse socio-cultural benefits and risks in the two significant environmental markets of carbon and water across three sites in Australia and Timor-Leste. Research into market-based policies to manage significant environmental issues is yet to fully consider socio-cultural dimensions. This project intends to document local community producers, distant investor and consumer perspectives, and incorpo ....Social implications of market-based policy instruments for carbon and water. This project aims to analyse socio-cultural benefits and risks in the two significant environmental markets of carbon and water across three sites in Australia and Timor-Leste. Research into market-based policies to manage significant environmental issues is yet to fully consider socio-cultural dimensions. This project intends to document local community producers, distant investor and consumer perspectives, and incorporate these perspectives into methods for improving the operation and impact of these expanding markets. By undertaking the first systematic comparison across resources and sites, the project expects to fill a key gap in environmental scholarship and contribute to international strategies to improve social and environmental outcomes in market-based environmental policy.Read moreRead less
Prerequisite conditions for Indigenous nation self-government. This project aims to produce new knowledge about Indigenous nation building (INB) processes. Based on research that self-governance increases Indigenous socioeconomic and community capacity, this project will collaborate with two Aboriginal communities to investigate factors that impact the transition from 'identifying' to 'organising' as political collectives to enable self-governance. Such knowledge has the potential to directly co ....Prerequisite conditions for Indigenous nation self-government. This project aims to produce new knowledge about Indigenous nation building (INB) processes. Based on research that self-governance increases Indigenous socioeconomic and community capacity, this project will collaborate with two Aboriginal communities to investigate factors that impact the transition from 'identifying' to 'organising' as political collectives to enable self-governance. Such knowledge has the potential to directly contribute to increased wellbeing for Indigenous communities as they define it. It aims to contribute to Australian and international Indigenous governance, political science and Indigenous methodologies literatures. The project could significantly benefit Indigenous peoples, the broader Australian community, Australian governments, and Australian and international INB researchers.Read moreRead less
Role Of IGF Binding Protein-3 (IGFBP-3) And IGFBP-5 As Modulators Of Nuclear Hormone Signalling
Funder
National Health and Medical Research Council
Funding Amount
$465,750.00
Summary
The insulin-like growth factors are small proteins involved in the growth of most tissues. Their actions are regulated by binding to larger proteins (known as IGFBPs) in the bloodstream and outside the cell. However, some IGFBPs are also found inside cells, where they seem to carry out other functions. We believe that two of these binding proteins, IGFBP-3 and IGFBP-5, change the way cells respond to vitamin A and vitamin D. These two vitamins are important in cell growth and in the way certain ....The insulin-like growth factors are small proteins involved in the growth of most tissues. Their actions are regulated by binding to larger proteins (known as IGFBPs) in the bloodstream and outside the cell. However, some IGFBPs are also found inside cells, where they seem to carry out other functions. We believe that two of these binding proteins, IGFBP-3 and IGFBP-5, change the way cells respond to vitamin A and vitamin D. These two vitamins are important in cell growth and in the way certain cells perform specialised functions. In test-tube experiments, IGFBP-3 and IGFBP-5 interact directly with the receptors that regulate the effects of these hormones. If the same thing happens inside the cell, IGFBP-3 and IGFBP-5 could change the way these receptors respond to signals from outside the cell. We will investigate what effect these IGFBPs have in living cells and in whole animals and how this may relate to human disease. If we are able to understand how IGFBP-3 and IGFBP-5 affect the way cells respond to vitamin A and D, then we may be able to develop new ways to treat certain human diseases.Read moreRead less
Learning catalysts: improving educational outcomes for disadvantaged children. This project will identify what works to improve educational outcomes for disadvantaged young people. In so doing, this project will contribute to Australia's prosperity and social well-being, and help address problems such as unemployment and homelessness, that arise when a large proportion of young Australians is denied an effective education.
Digital technologies and the private rental sector in Australia. This project aims to show how digital technologies are transforming the private rental sector in Australia. This project expects to generate new knowledge about the growing global reach of digital technologies aimed at private renters, landlords and property managers. The expected outcomes of this project include the production of social scientific knowledge about the potential of digital technologies to be both socially pernicious ....Digital technologies and the private rental sector in Australia. This project aims to show how digital technologies are transforming the private rental sector in Australia. This project expects to generate new knowledge about the growing global reach of digital technologies aimed at private renters, landlords and property managers. The expected outcomes of this project include the production of social scientific knowledge about the potential of digital technologies to be both socially pernicious and socially progressive. This project should provide significant benefits for Australian renters and our tenant advocacy partners who represent them, and to show how digital technologies can be used to create a better housing system.Read moreRead less