The Role Of Duffy And PF4 In The Platelet Killing Of Malaria Parasites.
Funder
National Health and Medical Research Council
Funding Amount
$350,045.00
Summary
Platelets in the blood can kill the Plasmodium parasite, which lives inside red blood cells and causes malaria. Platelets bind parasite-infected red cells and release a molecule that is toxic to the parasite. This project will study why a red cell molecule called Duffy is also needed for this function of platelets. Most Africans carry a gene for Duffy that stops its expression in red cells, and may therefore be more susceptible to malaria because their platelets cannot kill the malaria parasite.
ARC Research Network in Spatially Integrated Social Science. The ARC Research Network in Spatially Integrated Social Science (SISS) builds Australia's capacity and capability for innovative, collaborative, cross-disciplinary effort to investigate the impacts of change on the behaviour and well-being of people and the fortunes of places. SISS theories and research tools permit the integration of diverse and complex databases, the generation of new synthetic datasets, the incorporation of spatial ....ARC Research Network in Spatially Integrated Social Science. The ARC Research Network in Spatially Integrated Social Science (SISS) builds Australia's capacity and capability for innovative, collaborative, cross-disciplinary effort to investigate the impacts of change on the behaviour and well-being of people and the fortunes of places. SISS theories and research tools permit the integration of diverse and complex databases, the generation of new synthetic datasets, the incorporation of spatial concepts into statistical analysis and modelling, powerful visualisation of information, and the building spatial decision support systems, to provide an improved evidence base and better informed decision-making to address the significant challenges facing Australia's people and its places.Read moreRead less
Arbovirus Activation And Modulation Of NLRP3 Inflammasome
Funder
National Health and Medical Research Council
Funding Amount
$779,720.00
Summary
This project aims to establish how mosquito borne viruses such as Ross River and dengue viruses interacts with the human host to cause disease, including how the virus evades the host’s immune response to persist and cause disease for prolonged periods. Knowing how differences in the virus and the host’s immune system interplay to cause asymptomatic to severely disabling disease will assist in devising new treatments and prevention programs to lessen the impact of these diseases in Australia.
Mosquito-borne alphaviruses such as Ross River and chikungunya viruses cause widespread epidemics and exert extreme pressure on the public health systems of affected regions. Alphaviruses spreads to joints and triggers a severe disease in those affected. There are no effective treatments or vaccines. The project will investigate virus-host interaction at the bite site. The outcome will be new knowledge to treat infection at the mosquito bite site to prevent joint disease.
Novel Insights Into The Pathobiology Of Alphavirus Infections
Funder
National Health and Medical Research Council
Funding Amount
$827,660.00
Summary
Infections with mosquito-borne viruses are increasing at an alarming rate worldwide. Ross River virus is endemic in parts of Australia, PNG and Pacific islands, while chikungunya virus is distributed globally and causes recurrent pandemics that involve millions of people. These viruses cause severe musculoskeletal disease for several months after infection. This project aims to establish how these viruses interact with the human host to cause disease and may provide a basis for new treatments.
Pedalling for change: cultural geography for traffic congestion innovation. This project aims to offer new knowledge about why commuter cycling has failed to increase at a time when leisure cycling grows exponentially. The project seeks to provide evidence about what cycling enables people to achieve through analysis of a database of media discourses, policies and most importantly the experiences of cyclists. Expected outcomes include an enhanced understanding of cycling as response to congestio ....Pedalling for change: cultural geography for traffic congestion innovation. This project aims to offer new knowledge about why commuter cycling has failed to increase at a time when leisure cycling grows exponentially. The project seeks to provide evidence about what cycling enables people to achieve through analysis of a database of media discourses, policies and most importantly the experiences of cyclists. Expected outcomes include an enhanced understanding of cycling as response to congestion and improved policy strategies for increasing purposeful cycling in cities including moving the focus from cycling participation rates to cultures of cycling. Australia will benefit from cycling growing as a mode of transport to attenuate traffic congestion in metropolitan centres.Read moreRead less
Navigating New Waters: Supporting Fisheries And Aquaculture Businesses To Pursue Seafood Tourism As A Diversification Pathway
Funder
Fisheries Research and Development Corporation
Funding Amount
$135,000.00
Summary
This project is a strategic initiative to support seafood businesses in diversifying into new economic markets. Amidst evolving global challenges and the impact of Covid-19 on the seafood industry, the need for diversification is more pressing than ever. The proposed project addresses this need by providing seafood business with the necessary support and resources to diversify into a sector which boasts much potential: seafood tourism. Seafood tourism presents a practical and feasible appro .... This project is a strategic initiative to support seafood businesses in diversifying into new economic markets. Amidst evolving global challenges and the impact of Covid-19 on the seafood industry, the need for diversification is more pressing than ever. The proposed project addresses this need by providing seafood business with the necessary support and resources to diversify into a sector which boasts much potential: seafood tourism. Seafood tourism presents a practical and feasible approach to diversification, which leverages the intrigue of marine environments and the seafood production process. Whilst feasible, there are inherent challenges and risks involved in pursuing this diversification pathway. This project directly responds to the request of F&A for support in navigating the diversification process. Central to its approach, is the delivery of decision-support tools which can facilitate informed decision-making and mitigate potential risks involved in diversifying. These tools will be vital in ensuring F&A businesses make sound and strategic decisions regarding their suitability to different seafood tourism models.
Objectives: 1. Identify the range of seafood tourism business models and determine success factors for different models. 2. Document and compare the operating environment and the regulations in each jurisdiction (across production, food safety, tourism) for establishing and maintaining seafood tourism enterprises. 3. Identify the business capacity and capability needed for successful seafood businesses, inclusive of skills, assets, and networks. 4. Develop decision support tools for seafood operators to undertake a first pass assessment of the potential suitability of different tourism models. Read moreRead less
This program of research is firmly focussed on the basic mechanisms involved in normal functioning of cells and tissues, followed by a step by step process to understand the abnormal or the diseased. The disease states we are investigating involve the blood and blood vessels, and when there is malfunction it may contribute to conditions as diverse as atherosclerosis, thrombosis, inflammation and cancer. The program thus addresses the fundamentals of diseases which are responsible for most deaths ....This program of research is firmly focussed on the basic mechanisms involved in normal functioning of cells and tissues, followed by a step by step process to understand the abnormal or the diseased. The disease states we are investigating involve the blood and blood vessels, and when there is malfunction it may contribute to conditions as diverse as atherosclerosis, thrombosis, inflammation and cancer. The program thus addresses the fundamentals of diseases which are responsible for most deaths in our society. We will use technology which is proven to provide precise information, the molecular and biochemical processes responsible for cell function (or malfunction). However in each individual project there will be a clear path to a clinical use, diagnostic or therapeutic. Indeed in a number of the components of the program there are already potential treatments and diagnostics in development and trial.Read moreRead less
Early Career Industry Fellowships - Grant ID: IE230100672
Funder
Australian Research Council
Funding Amount
$470,337.00
Summary
Measuring real-time mental workload to improve our Defence capability. This project aims to develop a novel platform for measuring real-time variation in the cognitive workload of humans working with advanced Defence technologies. The project expects to combine innovative statistical techniques with cutting-edge psychological and neuroscience developments to measure and process workload-related brain activity in real-time. Expected outcomes of the project include an enhanced capacity to measure ....Measuring real-time mental workload to improve our Defence capability. This project aims to develop a novel platform for measuring real-time variation in the cognitive workload of humans working with advanced Defence technologies. The project expects to combine innovative statistical techniques with cutting-edge psychological and neuroscience developments to measure and process workload-related brain activity in real-time. Expected outcomes of the project include an enhanced capacity to measure and respond to cognitive workload in the field. This should provide significant benefits such as enhanced performance and safety outcomes, which will provide a strategic advantage to the Australian Defence Force by facilitating the development of advanced technologies that respond to the capabilities of the human user.Read moreRead less
Changing approaches to gender and development in rural China. Harmonious and cooperative relations with China are crucial to Australia's economic and cultural development and to security in the region. By contributing to Australian understanding of Chinese society, this project will enhance such relations. Knowledge gained through this project will also enhance Australian development projects in China, and more generally, contribute to development projects focusing on gender and development in A ....Changing approaches to gender and development in rural China. Harmonious and cooperative relations with China are crucial to Australia's economic and cultural development and to security in the region. By contributing to Australian understanding of Chinese society, this project will enhance such relations. Knowledge gained through this project will also enhance Australian development projects in China, and more generally, contribute to development projects focusing on gender and development in Asia and elsewhere. In addition, the contributions of the project to research and postgraduate training in Chinese studies, gender studies and development studies will benefit Australia by raising the international profile of Australian institutions within these disciplines.Read moreRead less