Integrating Immunity And Genetics In Follicular Lymphoma To Establish A Prognostic Score Fit For The Modern Era
Funder
National Health and Medical Research Council
Funding Amount
$1,377,174.00
Summary
Follicular lymphoma (FL) is divided into early and advanced stages. Early stage FL is frequently cured, but there is no way to identify who will be cured and who won't. By contrast advanced stage FL is incurable. Our unique access to well-annotated clinical trial and population based cohorts allows us to perform a detailed biological comparison of early and advanced FL, to gain a deeper understanding of the impediments to eradicating the disease, and to predict outcome to conventional therapy.
Tuberculosis is one of the most threatening infectious diseases worldwide due to the low efficiency of the only licensed anti-tuberculosis vaccine, BCG. This project aims to interrogate two previously neglected immune mechanisms and their potential to enhance vaccine-induced immunity by incorporating these mechanisms into new genetically modified BCG strains. We will also investigate alternative BCG vaccination routes to generate long-lived immune cells that can rapidly control the infection.
Transport and innate immune properties of DNA in bacterial nano-sized vesicles. All types of living organisms release nano-sized membrane vesicles or “blebs” which they use for intercellular communication and transport of molecules. This project will determine how bacteria package DNA within these vesicles, how this DNA is transported into host cells and how it triggers immune responses in these cells.
Functional Dyspepsia: Characterisation Of The Immunopathology And Testing A Novel Therapeutic Strategy.
Funder
National Health and Medical Research Council
Funding Amount
$739,604.00
Summary
Dyspepsia, unexplained stomach discomfort and pain, is a common and costly problem; few effective treatments exist and the causes are unknown. We have found that the numbers of a type of immune cell, the eosinophil, are increased in the top of the small bowel in patients with dyspepsia. This study will explore the mechanisms that lead to increased eosinophils and then test the effectiveness of a treatment to suppress this overactive immune response which could rapidly change clinical practice.
Reconceptualising industry sector development within the contemporary Australian city: The case of the information technology sector. This project will aim to uncover the reasons why Australia's Information Technology industry is ranked low among OECD countries by evaluating the impact of global and urban geography of the sector on the sector's performance. It will show how policies to achieve more advanced IT sector development need to consider Australia's distinctive position in the global eco ....Reconceptualising industry sector development within the contemporary Australian city: The case of the information technology sector. This project will aim to uncover the reasons why Australia's Information Technology industry is ranked low among OECD countries by evaluating the impact of global and urban geography of the sector on the sector's performance. It will show how policies to achieve more advanced IT sector development need to consider Australia's distinctive position in the global economy and particular factors in the Sydney and Melbourne IT clusters that both help, and hinder, development in ways not considered in present policy models.Read moreRead less
During injury or infection, our body’s immune system protects us by launching inflammation. But uncontrolled inflammation drives common diseases such as cancer, diabetes and Alzheimer’s. This project will reveal how the body produces interleukin-1? – a protein at the heart of inflammation and disease – so we can design better strategies for treating patients with inflammation-driven disease.
Special Research Initiatives - Grant ID: SR0354576
Funder
Australian Research Council
Funding Amount
$30,000.00
Summary
Spatially Integrated Social Science Research in Australia. Rapid change across society has resulted in shifts to the scope of social science research including the emergence of space and place as an important concept. Across research fields the result has been that a range of innovative and unique techniques, methodologies and theories that are space based are now being developed. While research is progressing rapidly, it is undertaken in parallel by researchers who can not always collaborate. ....Spatially Integrated Social Science Research in Australia. Rapid change across society has resulted in shifts to the scope of social science research including the emergence of space and place as an important concept. Across research fields the result has been that a range of innovative and unique techniques, methodologies and theories that are space based are now being developed. While research is progressing rapidly, it is undertaken in parallel by researchers who can not always collaborate. Recognising these advances, this initiative focuses on harnessing Australia's capacity and potential in the use of spatially based methods and theories and brings researchers together in collaboration across a number of fields. Read moreRead less
ARC Research Network in Spatially Integrated Social Science. The ARC Research Network in Spatially Integrated Social Science (SISS) builds Australia's capacity and capability for innovative, collaborative, cross-disciplinary effort to investigate the impacts of change on the behaviour and well-being of people and the fortunes of places. SISS theories and research tools permit the integration of diverse and complex databases, the generation of new synthetic datasets, the incorporation of spatial ....ARC Research Network in Spatially Integrated Social Science. The ARC Research Network in Spatially Integrated Social Science (SISS) builds Australia's capacity and capability for innovative, collaborative, cross-disciplinary effort to investigate the impacts of change on the behaviour and well-being of people and the fortunes of places. SISS theories and research tools permit the integration of diverse and complex databases, the generation of new synthetic datasets, the incorporation of spatial concepts into statistical analysis and modelling, powerful visualisation of information, and the building spatial decision support systems, to provide an improved evidence base and better informed decision-making to address the significant challenges facing Australia's people and its places.Read moreRead less