Immune-imprinting nanoparticles (iNPs). This research promises new classes of immune-imprinting, biodegradable nanoparticles (iNPs) with anti-inflammatory properties. The engineering of such particles requires fundamental understanding of their properties that enable specific cellular interactions to regulate immunity with new anti-inflammatory pathways. For pulmonary delivery, spray-dried amino acid microspheres with tailored surfaces as carriers can be generated using the innovative microfluid ....Immune-imprinting nanoparticles (iNPs). This research promises new classes of immune-imprinting, biodegradable nanoparticles (iNPs) with anti-inflammatory properties. The engineering of such particles requires fundamental understanding of their properties that enable specific cellular interactions to regulate immunity with new anti-inflammatory pathways. For pulmonary delivery, spray-dried amino acid microspheres with tailored surfaces as carriers can be generated using the innovative microfluidic drying approach. The potential applications of iNPs are wide-ranging and are not restricted to pulmonary targeting. The potential commercial implications for Australia's emerging biopharmaceutical industry are substantial.Read moreRead less
Recognition of lipid antigens by the immune system. T cells are a critical component of the immune system, protecting against a range of pathogens by detecting and responding to foreign molecules. Despite their importance, there is still much to learn about how T cells function. New types of T cells that respond to bacteria-derived lipid molecules, have recently been identified. This project aims to undertake a molecular and functional investigation into lipid-reactive T cells. This will provide ....Recognition of lipid antigens by the immune system. T cells are a critical component of the immune system, protecting against a range of pathogens by detecting and responding to foreign molecules. Despite their importance, there is still much to learn about how T cells function. New types of T cells that respond to bacteria-derived lipid molecules, have recently been identified. This project aims to undertake a molecular and functional investigation into lipid-reactive T cells. This will provide basic fundamental insight into a poorly understood, but crucial, component of the immune system as well as an opportunity to ultimately develop novel lipid-based vaccines.Read moreRead less
Transport and innate immune properties of DNA in bacterial nano-sized vesicles. All types of living organisms release nano-sized membrane vesicles or “blebs” which they use for intercellular communication and transport of molecules. This project will determine how bacteria package DNA within these vesicles, how this DNA is transported into host cells and how it triggers immune responses in these cells.
Discovery Early Career Researcher Award - Grant ID: DE160100501
Funder
Australian Research Council
Funding Amount
$342,119.00
Summary
Where is the justice? Theorising the legacy of the Khmer Rouge Tribunal. This project seeks to advance theories that explain the social and political effects of international criminal tribunals. It is widely claimed that international tribunals, in addition to providing legal justice, work to enhance the rule of law, respect for human rights and national reconciliation in post-conflict contexts. Taking the Khmer Rouge Tribunal as its case, this project aims to critically analyse such claims by i ....Where is the justice? Theorising the legacy of the Khmer Rouge Tribunal. This project seeks to advance theories that explain the social and political effects of international criminal tribunals. It is widely claimed that international tribunals, in addition to providing legal justice, work to enhance the rule of law, respect for human rights and national reconciliation in post-conflict contexts. Taking the Khmer Rouge Tribunal as its case, this project aims to critically analyse such claims by interrogating the non-judicial legacies of documentation, memorialisation and the provision of collective reparations. Knowing more about these key non-judicial legacies and how tribunals enhance the rule of law, human rights and national reconciliation, may help inform the design of tribunals worldwide.Read moreRead less
Special Research Initiatives - Grant ID: SR0354576
Funder
Australian Research Council
Funding Amount
$30,000.00
Summary
Spatially Integrated Social Science Research in Australia. Rapid change across society has resulted in shifts to the scope of social science research including the emergence of space and place as an important concept. Across research fields the result has been that a range of innovative and unique techniques, methodologies and theories that are space based are now being developed. While research is progressing rapidly, it is undertaken in parallel by researchers who can not always collaborate. ....Spatially Integrated Social Science Research in Australia. Rapid change across society has resulted in shifts to the scope of social science research including the emergence of space and place as an important concept. Across research fields the result has been that a range of innovative and unique techniques, methodologies and theories that are space based are now being developed. While research is progressing rapidly, it is undertaken in parallel by researchers who can not always collaborate. Recognising these advances, this initiative focuses on harnessing Australia's capacity and potential in the use of spatially based methods and theories and brings researchers together in collaboration across a number of fields. Read moreRead less
ARC Research Network in Spatially Integrated Social Science. The ARC Research Network in Spatially Integrated Social Science (SISS) builds Australia's capacity and capability for innovative, collaborative, cross-disciplinary effort to investigate the impacts of change on the behaviour and well-being of people and the fortunes of places. SISS theories and research tools permit the integration of diverse and complex databases, the generation of new synthetic datasets, the incorporation of spatial ....ARC Research Network in Spatially Integrated Social Science. The ARC Research Network in Spatially Integrated Social Science (SISS) builds Australia's capacity and capability for innovative, collaborative, cross-disciplinary effort to investigate the impacts of change on the behaviour and well-being of people and the fortunes of places. SISS theories and research tools permit the integration of diverse and complex databases, the generation of new synthetic datasets, the incorporation of spatial concepts into statistical analysis and modelling, powerful visualisation of information, and the building spatial decision support systems, to provide an improved evidence base and better informed decision-making to address the significant challenges facing Australia's people and its places.Read moreRead less
Barriers and Facilitators of Neighbourhood Networks and Cohesion. Neighbourhoods are critical contexts for health, safety and well-being. In the face of significant urban growth, understanding and enhancing neighbourhood networks and cohesion are high priorities in Australia and internationally. Drawing on longitudinal survey data from 148 Brisbane suburbs combined with census and spatial data, this project will be the first to examine how a neighbourhood's physical and socio-structural context ....Barriers and Facilitators of Neighbourhood Networks and Cohesion. Neighbourhoods are critical contexts for health, safety and well-being. In the face of significant urban growth, understanding and enhancing neighbourhood networks and cohesion are high priorities in Australia and internationally. Drawing on longitudinal survey data from 148 Brisbane suburbs combined with census and spatial data, this project will be the first to examine how a neighbourhood's physical and socio-structural context influences neighbourhood networks and cohesion over time and across the landscape of an entire city. The project aims to advance scientific understanding of neighbourhood networks and cohesion, provide unique insights into its underpinning drivers, and inform urban policy.Read moreRead less
The role of immuno-exosomes in innate immunity. This project aims to determine the role of exosomes (EV) in innate immunity. Exosomes are extracellular vesicles secreted by mammalian cells that have an important biological function in intercellular communication by transferring biologically active proteins, lipids, and RNAs to neighbouring or distant cells. Following exposure to a foreign organism, cells dynamically change the protein composition of the EV they secrete. While this data supports ....The role of immuno-exosomes in innate immunity. This project aims to determine the role of exosomes (EV) in innate immunity. Exosomes are extracellular vesicles secreted by mammalian cells that have an important biological function in intercellular communication by transferring biologically active proteins, lipids, and RNAs to neighbouring or distant cells. Following exposure to a foreign organism, cells dynamically change the protein composition of the EV they secrete. While this data supports a role for EV as key players in innate immunity, a full understanding of the biological relevance of these vesicles and how they serve as a cellular defence mechanism is lacking. This project will provide significant benefits such as addressing key questions in EV biology and providing new fundamental insights into a novel and poorly understood component of the innate immune response.Read moreRead less
Co-designing Innovations in Digital Storytelling with Older Adults. This project aims to investigate how emerging technologies can be leveraged to provide innovative ways for older adults to create and share their life stories to foster social wellbeing. Later life can be a time of considerable change, leaving people feeling disconnected from the people, places, and life events that are important to them. Autobiographical storytelling can help create links with one's past, but little is known ab ....Co-designing Innovations in Digital Storytelling with Older Adults. This project aims to investigate how emerging technologies can be leveraged to provide innovative ways for older adults to create and share their life stories to foster social wellbeing. Later life can be a time of considerable change, leaving people feeling disconnected from the people, places, and life events that are important to them. Autobiographical storytelling can help create links with one's past, but little is known about how technologies such as digital games and virtual reality can be used to enable older adults to share stories about their lives in a way that supports ongoing social interactions. This project is expected to co-design new forms of digital storytelling to improve social wellbeing of older adults. Read moreRead less
Unaffordable housing: impacts on socio-economic conditions and wellbeing . The project plans to explore how the current housing affordability crisis is shaping population wellbeing and socioeconomic outcomes. Housing affordability is a key driver of health-related inequalities – the dramatic rise in the cost of housing in the past decade is forcing people to make hard decisions about location and quality of housing. This project aims to provide a new framework for analysing housing affordability ....Unaffordable housing: impacts on socio-economic conditions and wellbeing . The project plans to explore how the current housing affordability crisis is shaping population wellbeing and socioeconomic outcomes. Housing affordability is a key driver of health-related inequalities – the dramatic rise in the cost of housing in the past decade is forcing people to make hard decisions about location and quality of housing. This project aims to provide a new framework for analysing housing affordability's long-term impact on wellbeing and socioeconomic outcomes by merging concepts from life course epidemiology on the importance of the timing, sequence and accumulation of exposure, to transition points at critical life stages from the social sciences. It plans to develop information to contribute to public discourse and improve policy in the area.Read moreRead less