Discovery Early Career Researcher Award - Grant ID: DE120101503
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Design of a biologically inspired running and climbing robotic lizard. Watch any movie and it will tell you that robots are the future. The trouble is that recent attempts to build running and climbing robots have had limited success. This project explores locomotion of lizards to improve upon shortfalls in current robotic design, to build biologically inspired robots capable of running and climbing up and down walls.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE170100206
Funder
Australian Research Council
Funding Amount
$550,000.00
Summary
Lattice light sheet microscopy for imaging biology in real space and time. This project aims to establish a Lattice Light-Sheet Microscope (LLSM) Facility, to provide the dedicated computing infrastructure needed for terabyte-scale image acquisition and handling. Lattice light sheet microscopy allows four-dimensional imaging of live biological specimens from individual molecules to small organisms. The microscope images live specimens without phototoxicity or photobleaching, enabling prolonged i ....Lattice light sheet microscopy for imaging biology in real space and time. This project aims to establish a Lattice Light-Sheet Microscope (LLSM) Facility, to provide the dedicated computing infrastructure needed for terabyte-scale image acquisition and handling. Lattice light sheet microscopy allows four-dimensional imaging of live biological specimens from individual molecules to small organisms. The microscope images live specimens without phototoxicity or photobleaching, enabling prolonged imaging of significant physiological or biophysical events. Expected outcomes include high impact discoveries and publications in fundamental research, rapid solutions for industry-focussed projects and opportunities for collaboration, research and development. The imaging is expected to reveal key scientific insights and showcase biology to the public.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE200100259
Funder
Australian Research Council
Funding Amount
$417,755.00
Summary
Hacking Housing: Technologies, processes and practices of housing futures. Australian’s experiences of housing are changing due to rising housing unaffordability, uncertain employment prospects & digital disruptions to housing markets. A diverse housing system is resulting, as housing providers & consumers innovate with novel housing models & practices to find solutions to housing problems. Contemporary housing thinking cannot grasp this reshaping of housing. The project aims to advance a new co ....Hacking Housing: Technologies, processes and practices of housing futures. Australian’s experiences of housing are changing due to rising housing unaffordability, uncertain employment prospects & digital disruptions to housing markets. A diverse housing system is resulting, as housing providers & consumers innovate with novel housing models & practices to find solutions to housing problems. Contemporary housing thinking cannot grasp this reshaping of housing. The project aims to advance a new conceptual framework & innovative methodologies to understand the new housing landscape as digital, rented & shared. It expects to generate new empirical knowledge using digital methodologies & grow international research networks. This should provide benefits such as evidence to inform policy & a digital methods toolkit.Read moreRead less
Industrial Transformation Research Hubs - Grant ID: IH190100021
Funder
Australian Research Council
Funding Amount
$4,999,540.00
Summary
ARC Research Hub to Combat Antimicrobial Resistance. The ARC ITRP Research Hub to Combat Antimicrobial Resistance takes on the global challenge of antimicrobial resistance (AMR) for Australia through a world-first partnership between industry, researchers, and end users. The AMR Hub fosters a pre-commercialisation environment to address both social and laboratory-based preclinical challenges to provide a highly integrated diagnostic, pharmaceutical and end user solution to the problem of AMR. A ....ARC Research Hub to Combat Antimicrobial Resistance. The ARC ITRP Research Hub to Combat Antimicrobial Resistance takes on the global challenge of antimicrobial resistance (AMR) for Australia through a world-first partnership between industry, researchers, and end users. The AMR Hub fosters a pre-commercialisation environment to address both social and laboratory-based preclinical challenges to provide a highly integrated diagnostic, pharmaceutical and end user solution to the problem of AMR. A goal of the Hub is to support the development of new molecular diagnostic technology, improve the processes for identifying potential antibiotic compounds and assess and advise on antimicrobial stewardship with a vision to transform social and health outcomes globally.Read moreRead less
Understanding How the Hungry Brain Regulates Metabolism. Energy homeostasis is essential for life as it ensures an adequate supply of fuel to cells of the body. This process is orchestrated by neurons in the hypothalamus of the brain. This project aims to determine the role of the extracellular matrix that surrounds hypothalamic neurons and how this regulates energy homeostasis, an area of science that is completely unexplored. This project expects to identify the composition the extracellular m ....Understanding How the Hungry Brain Regulates Metabolism. Energy homeostasis is essential for life as it ensures an adequate supply of fuel to cells of the body. This process is orchestrated by neurons in the hypothalamus of the brain. This project aims to determine the role of the extracellular matrix that surrounds hypothalamic neurons and how this regulates energy homeostasis, an area of science that is completely unexplored. This project expects to identify the composition the extracellular matrix within the hypothalamus and discover how it regulates energy homeostasis. The outcomes of this project are to provide new knowledge in understanding how the brain regulates metabolism, to promote population health & wellbeing, develop new technologies and training the next generation of researchers.Read moreRead less
Detecting, preventing and responding to image-based abuse. This project aims to investigate the efficacy of digital tools and interventions to detect, prevent and respond to image-based abuse (the non-consensual creation or distribution of intimate images). Through a digital ethnography, victim and stakeholder interviews, online surveys, and an AI chatbot, the project expects to generate evidence and theory on both image-based abuse and internet governance. The expected outcomes include: increas ....Detecting, preventing and responding to image-based abuse. This project aims to investigate the efficacy of digital tools and interventions to detect, prevent and respond to image-based abuse (the non-consensual creation or distribution of intimate images). Through a digital ethnography, victim and stakeholder interviews, online surveys, and an AI chatbot, the project expects to generate evidence and theory on both image-based abuse and internet governance. The expected outcomes include: increased understanding of the responsibility of digital platforms and the drivers of image-based abuse; improved platform and service responses; enhanced industry and scholarly collaborations; and harm reduction. Expected benefits include improved laws, polices and practices to tackle image-based abuse.Read moreRead less
Radio-magnetic nanoparticles as bimodal positron emission tomography/magnetic resonance imaging contrast agents for dendritic cell tracking. Biomedical imaging is limited by a lack of commercial dual-mode contrast agents, which may be simultaneously used for magnetic resonance (MR) and positron emission tomography (PET) imaging. This project will develop a nanotechnology-based biocompatible dual-mode contrast agent for simultaneous PET and MR imaging, reducing associated side effects.
Discovery Early Career Researcher Award - Grant ID: DE140101553
Funder
Australian Research Council
Funding Amount
$395,220.00
Summary
A flexible virus-like particle delivery platform for next-generation vaccines. Murine polyomavirus (MPyV) capsid proteins self-assemble into spherical protein shells approximately 45 nm in diameter. Such virus-like particles (VLPs) are of considerable interest as bionanotechnological tools. The unique flexibility provided by MPyV VLPs will be exploited by exploring the ability of the interior cavity to retain bioactive cargos while engineering novel functionality on the exterior surface by 'mix- ....A flexible virus-like particle delivery platform for next-generation vaccines. Murine polyomavirus (MPyV) capsid proteins self-assemble into spherical protein shells approximately 45 nm in diameter. Such virus-like particles (VLPs) are of considerable interest as bionanotechnological tools. The unique flexibility provided by MPyV VLPs will be exploited by exploring the ability of the interior cavity to retain bioactive cargos while engineering novel functionality on the exterior surface by 'mix-and-match' assembly of VLPs from modified components. As a proof of concept for next-generation vaccines that stimulate much needed, broadly protective responses against infectious diseases, model antigens will be delivered to specific immune cells using this nano-container.Read moreRead less
The control of chromosome division during female meiosis. Mammalian eggs are stored life-long and finally mature in the hours before ovulation. This project examines how the chromosomes in the egg are separated properly so as to produce a mature egg capable of being fertilized by a sperm. Often in eggs chromosome division is imprecisely executed, and this project will help us understand why this occurs.
Imaging the foundation of the nervous system. This Project aims to understand the formation of the neural tube; a fundamental tissue structure that generates the brain and the spinal cord. Using interdisciplinary approaches and exploiting recent advances in transgenic and imaging technologies, the Project expects to reveal the complex interplay of molecular, cellular and mechanical processes that direct neural tissue formation and cell fate specification. Outcomes from the Project include knowle ....Imaging the foundation of the nervous system. This Project aims to understand the formation of the neural tube; a fundamental tissue structure that generates the brain and the spinal cord. Using interdisciplinary approaches and exploiting recent advances in transgenic and imaging technologies, the Project expects to reveal the complex interplay of molecular, cellular and mechanical processes that direct neural tissue formation and cell fate specification. Outcomes from the Project include knowledge of previously intractable developmental processes, training of future scientists and development of international collaborations. This should provide enhanced imaging capacity, a higher quality scientific workforce and position Australia at the forefront of developmental biology.
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