Inhibition Of IFN-?/? By Human Metapneumovirus And The Induction Of Inflammation
Funder
National Health and Medical Research Council
Funding Amount
$605,251.00
Summary
The newly isolated human metapneumovirus (hMPV) causes significant respiratory illness in infants, young children and the elderly. The virus can persist long-term and may predispose individuals to chronic lung disease. This proposal aims to determine the mechanisms by which hMPV infection causes respiratory disease, with a view to improving treatments and preventing disease.
Mechanism/s Of Disease Caused By Respiratory Viral Infections
Funder
National Health and Medical Research Council
Funding Amount
$479,517.00
Summary
A newly discovered respiratory virus, human metapneumovirus (HMPV), causes clinical disease that is very similar to human respiratory syncytial virus (RSV) and co-circulates with RSV. Human RSV is a major cause of morbidity and life-threatening respiratory tract disease in infants and young children worldwide, and is recognised as an important respiratory pathogen in elderly adults and immune compromised patients. The recent isolation of HMPV from children hospitalised with respiratory tract ill ....A newly discovered respiratory virus, human metapneumovirus (HMPV), causes clinical disease that is very similar to human respiratory syncytial virus (RSV) and co-circulates with RSV. Human RSV is a major cause of morbidity and life-threatening respiratory tract disease in infants and young children worldwide, and is recognised as an important respiratory pathogen in elderly adults and immune compromised patients. The recent isolation of HMPV from children hospitalised with respiratory tract illness similar to RSV, but with an unknown etiology, suggests that HMPV may mediate similar clinical pathology. Nothing is currently known about the immune response to HMPV, or the association of these responses with lung disease. The objectives of this proposal are to elucidate the mechanisms of immunity and disease pathogenesis associated with human metapneumovirus (HMPV) and to investigate the use of a novel vaccine to protect against HMPV infection. Once this data is obtained, the study will provide the foundation for further research in the development of vaccines or therapeutic protocols to treat HMPV. It will also provide valuable information for understanding the disease in humans. Also,it is likely that HMPV, like hRSV, may prove to be an agent associated with long-term decreased pulmonary function and airflow limitation perhaps developing to asthma.Read moreRead less
RNAi Therapeutic Intervention Of Human Viral Respiratory Disease
Funder
National Health and Medical Research Council
Funding Amount
$584,117.00
Summary
Human metapneumovirus (HMPV), causes clinical disease that is very similar to human respiratory syncytial virus (RSV) and co-circulates with RSV. HMPV is emerging as a major cause of morbidity and life-threatening respiratory tract disease in infants, young children and the elderly worldwide. No treatment is currently available. The objectives of this proposal are to develop novel antiviral drugs that silence the expression of viral genes and to examine protection against the disease.
Mechanisms Of Induction And Progression Of Childhood Asthma: Investigations In A Mouse Model
Funder
National Health and Medical Research Council
Funding Amount
$517,586.00
Summary
This project investigates how certain respiratory viral infections in very young children might predispose to developing asthma, and how inflammation in the airways in asthma might then worsen. The experimental work, which will use unique mouse models developed in the laboratories of the chief investigators, will focus on changes in genes that control the pattern of immune response to allergens and that regulate the progression of inflammation.
Gender and Employment Equity: Strategies for Advancement in Australian Universities. Gender inequity in pay and employment remain a feature of Australian society and can impair labour productivity. Lower female labour force participation rates continue to be a major issue, resulting in less than optimum use of women's skills. This project undertakes detailed analysis of these issues in Australian Universities, the major training site for the national skilled workforce. It will develop practical ....Gender and Employment Equity: Strategies for Advancement in Australian Universities. Gender inequity in pay and employment remain a feature of Australian society and can impair labour productivity. Lower female labour force participation rates continue to be a major issue, resulting in less than optimum use of women's skills. This project undertakes detailed analysis of these issues in Australian Universities, the major training site for the national skilled workforce. It will develop practical strategies to promote gender equity in universities. As women's participation is a major driver of labour force growth, this research will provide vital information for many industries.Read moreRead less
Trends in Time: Work, Family and Social Policy in Australia 1992-2006. This project will contribute to the national priority goal of 'strengthening Australia's social and economic fabric to help families and individuals live healthy, productive, and fulfilling lives', within the National Research Priority of 'promoting good health and well being for all Australians'. It will provide sound new evidence for effective strategies fostering the policy goals of reducing stress on families, maintaining ....Trends in Time: Work, Family and Social Policy in Australia 1992-2006. This project will contribute to the national priority goal of 'strengthening Australia's social and economic fabric to help families and individuals live healthy, productive, and fulfilling lives', within the National Research Priority of 'promoting good health and well being for all Australians'. It will provide sound new evidence for effective strategies fostering the policy goals of reducing stress on families, maintaining fertility and encouraging women into paid work. Identifying measures that most support men and women to balance work-family commitments, to spend adequate time with their children and social networks, and most facilitate female workforce participation, will promote national wellbeing. Read moreRead less
Negotiating the Life Course: Education, Work, Family and Lifestyle Behaviour in Australia. The Negotiating the Life Course Project is a leading Australian social science resource accessible to and widely used by university researchers and students, especially PhD students. Beyond its major academic contributions, its results have been extensively reported in the media and have greatly increased community understanding of Australian society. It has an important and on-going role in several areas ....Negotiating the Life Course: Education, Work, Family and Lifestyle Behaviour in Australia. The Negotiating the Life Course Project is a leading Australian social science resource accessible to and widely used by university researchers and students, especially PhD students. Beyond its major academic contributions, its results have been extensively reported in the media and have greatly increased community understanding of Australian society. It has an important and on-going role in several areas of policy formulation especially in the development of policies related to the balance of work and family. Its principals are leading social commentators in these policy areas because, in large part, they are able to draw upon this significant national resource. Read moreRead less
Negotiating the Lifecourse: Longitudinal research into work and family transitions and trajectories. The Negotiating the Life Course Project is a leading Australian social science resource widely used by university researchers and students, especially PhD students. The research on life course pathways will see Australian researchers contribute to major advances that are being made in this field, particularly in Europe. Beyond its major academic contributions, results have been extensively report ....Negotiating the Lifecourse: Longitudinal research into work and family transitions and trajectories. The Negotiating the Life Course Project is a leading Australian social science resource widely used by university researchers and students, especially PhD students. The research on life course pathways will see Australian researchers contribute to major advances that are being made in this field, particularly in Europe. Beyond its major academic contributions, results have been extensively reported in the media and have increased community understanding of Australian society. It has an important role in several areas of policy formulation especially in work/family, housing and education. Its principals are leading social commentators in these policy areas partly because they are able to draw upon this significant national resource. Read moreRead less
Understanding gender inequality in the post-pandemic future of work. This project examines the impact of the COVID-19 pandemic and economic crisis on the working futures of young women and men in three advanced market economies where the pandemic hit with varying degrees of severity. Young people have experienced the greatest upheaval of all workers, and the impact has been gendered. Recovery strategies will have lasting consequences for women’s and men’s working futures. The project will produc ....Understanding gender inequality in the post-pandemic future of work. This project examines the impact of the COVID-19 pandemic and economic crisis on the working futures of young women and men in three advanced market economies where the pandemic hit with varying degrees of severity. Young people have experienced the greatest upheaval of all workers, and the impact has been gendered. Recovery strategies will have lasting consequences for women’s and men’s working futures. The project will produce macro-level mapping of post-pandemic national work/care regimes, and micro-level survey data on young people’s experience of and attitudes to the future of work in Australia, the UK and Japan, to deliver insights on the gendered economic and social impact of the pandemic and inform a more inclusive global recovery.Read moreRead less