T cell recognition and control of virus: the balance between T cell receptor diversity and degeneracy. T cells provide an important line of defence in the immune system's resistance against infectious diseases. However, changes to the T cell population during prolonged infection, and with age, can compromise the immune system's ability to fight effectively viral infections. The proposed research will greatly improve our understanding of the recognition and control of viral infections by T cells. ....T cell recognition and control of virus: the balance between T cell receptor diversity and degeneracy. T cells provide an important line of defence in the immune system's resistance against infectious diseases. However, changes to the T cell population during prolonged infection, and with age, can compromise the immune system's ability to fight effectively viral infections. The proposed research will greatly improve our understanding of the recognition and control of viral infections by T cells. The insights gained from this research will enable us to exploit key features of T cell responses to improve the outcome of viral infections in elderly individuals and to develop better vaccines for protection against a range of infectious diseases that affect the Australian population, including HIV and Hepatitis C.Read moreRead less
Gene therapy for islet transplantation. Improved understanding of aetiology of type I diabetes. Development of islet transplantation as a clinical therapeutic for type I diabetes. Improved efficacy of islet transplantation. Improved health for subjects with type I diabetes. Decreased diabetic complications. Improved quality of life for subjects with type I diabetes. Reduced burden on health system for management of diabetic complications for subjects with type I diabetes
Molecular and immunological approaches to managing Australia's seafood allergy epidemic. Seafood is an increasingly important cause of food allergy. Novel insight into the functions of why and how proteins from seafood develop to potent allergens will lead to the development of better diagnostics and therapeutics. This will assist patients to better manage their serious food allergy.
The nature and consequences of environmentally-generated phenotypic variation in natural populations. The ambient environment can generate both heritable and non-heritable variation in individual traits, but the role of such variation in evolution is poorly understood. This project will use a powerful model organism, the Australian neriid flies, to elucidate the evolutionary implications of environmentally-generated variation.
New platform technologies for the chemical synthesis of post-translationally modified proteins. The last decade has seen an explosion in the number of protein drugs approved for use in the clinic, a large proportion of which possess post-translational modifications (PTMs). These modified protein drugs are produced and sold as mixtures which has led to difficulties in understanding the role of specific PTMs on activity and in gaining clinical approval for candidate drugs. This project will provid ....New platform technologies for the chemical synthesis of post-translationally modified proteins. The last decade has seen an explosion in the number of protein drugs approved for use in the clinic, a large proportion of which possess post-translational modifications (PTMs). These modified protein drugs are produced and sold as mixtures which has led to difficulties in understanding the role of specific PTMs on activity and in gaining clinical approval for candidate drugs. This project will provide a fundamental solution to this problem through the development of novel synthetic methods and a powerful new platform technology for accessing PTM proteins in pure form. The utility of this technology will be demonstrated through its use in the total chemical synthesis of a range of PTM proteins for applications in biology and medicine.Read moreRead less
Drought effects on soil carbon and nitrogen cycling mediated by rhizosphere processes. There is much uncertainty about how drought caused by global warming will affect agricultural sustainability in Australia. This project will provide new knowledge about plant-soil interactions affecting carbon and nutrient cycling and will make predictions about long-term soil carbon storage and agricultural productivity in response to drought.
Bridging the gap between crop pollination services and pollinator health. Insect pollinators play an integral role in the quantity and quality of production for many food crops, yet there is growing concern that in agricultural landscapes, the limited availability of floral and non-floral resources might be contributing to global pollinator health declines. This project will synthesize global datasets, develop new methodological tools and conduct new, targeted empirical work to develop an integ ....Bridging the gap between crop pollination services and pollinator health. Insect pollinators play an integral role in the quantity and quality of production for many food crops, yet there is growing concern that in agricultural landscapes, the limited availability of floral and non-floral resources might be contributing to global pollinator health declines. This project will synthesize global datasets, develop new methodological tools and conduct new, targeted empirical work to develop an integrated approach to pollinator resource management with the explicit objectives of maintaining both wild pollinator health and to support crop pollination service delivery in modified systems.Read moreRead less