Multistage Vaccines For The Prevention Of Tuberculosis
Funder
National Health and Medical Research Council
Funding Amount
$884,290.00
Summary
Almost two million people die from tuberculosis (TB) each year. The current vaccine, BCG, is ineffective at controlling TB and the type of immune response needed to protect against the disease is poorly understood. We have discovered new antigens of the TB bacterium, and we will combine them with novel delivery strategies to develop new TB vaccines. We will also determine the type of immune response needed to protect against TB, which will aid progression of vaccines into clinical trials.
Functional analysis of Bacillus thuringiensis crystal toxins. Pore-forming toxins, such as anthrax, hemolysin, cholera and diphtheria toxins, are among the most virulent microbial toxins, posing a threat to humans and lifestock. We are using a novel functional approach to test possible lectin and antimicrobial peptide functions of a typical and economically important pore-forming toxin, the crystal endotoxin from Bacillus thuringiensis, to examine why toxicity of the lectin-containing toxin is ....Functional analysis of Bacillus thuringiensis crystal toxins. Pore-forming toxins, such as anthrax, hemolysin, cholera and diphtheria toxins, are among the most virulent microbial toxins, posing a threat to humans and lifestock. We are using a novel functional approach to test possible lectin and antimicrobial peptide functions of a typical and economically important pore-forming toxin, the crystal endotoxin from Bacillus thuringiensis, to examine why toxicity of the lectin-containing toxin is restricted to invertebrates only, while the amphipathic peptide alone is also toxic to many vertebrate cells. The outcome of these experiments has important implications for the sustainable use of biopesticides and for the prevention and containment of infectious diseases.Read moreRead less
Innovation in agricultural sector Green House Gas abatement in NSW. This project aims to develop a land sector greenhouse gas abatement, food production and environmental economics model for NSW. We expect to identify innovation in carbon payment policy and brokerage business models to achieve agricultural GHG abatement, while simultaneously improving sustainability. Expected outcomes include evaluation of the innovations of expert landholders, related businesses and governments to find ways to ....Innovation in agricultural sector Green House Gas abatement in NSW. This project aims to develop a land sector greenhouse gas abatement, food production and environmental economics model for NSW. We expect to identify innovation in carbon payment policy and brokerage business models to achieve agricultural GHG abatement, while simultaneously improving sustainability. Expected outcomes include evaluation of the innovations of expert landholders, related businesses and governments to find ways to influence land use decisions. This should provide significant benefits to landholders, governments involved in land management and the public through increased productivity, profitability, biodiversity and ecosystem health in the context of future climate, agricultural commodity and carbon market uncertainties.Read moreRead less
Extraction of flavour enhancers, antimicrobials and nutraceuticals from olive mill effluent. The project aims to recover valuable materials from olive mill waste. Natural flavours will be recovered from the wastewater and from the dry pomice after oil extraction. The research and development will see these flavour compounds added back to olive oil to enhance the flavours of bland oils and to increase the shelf life of olive oil. The same compounds also have uses as enhancing the flavours of food ....Extraction of flavour enhancers, antimicrobials and nutraceuticals from olive mill effluent. The project aims to recover valuable materials from olive mill waste. Natural flavours will be recovered from the wastewater and from the dry pomice after oil extraction. The research and development will see these flavour compounds added back to olive oil to enhance the flavours of bland oils and to increase the shelf life of olive oil. The same compounds also have uses as enhancing the flavours of foods in general and provide a source of naturally occurring antioxidants. The compounds will be tested as natural antibiotics as a means of controlling fungal infections in vineyards and in vegetable production. Read moreRead less
The development of vaccines and better treatments for HIV-AIDS and Hepatitis C are urgent global health priorities. This Program will undertake studies to better understand effective immunity against HIV and hepatitis C, allowing the rational design and testing of novel vaccines and treatments. The Program brings together a team of researchers with skills in basic virology and immunology with those providing expertise in translating findings in the laboratory into human clinical trials.
The Male Partner Contribution To Pregnancy Immune Tolerance Deficit In Women
Funder
National Health and Medical Research Council
Funding Amount
$1,462,925.00
Summary
A complication-free pregnancy and birth of a healthy infant depends on adequate preparation of the mother's immune system to tolerate the 'foreign' fetus, Both the mother and the father contribute to establishing optimal immune tolerance. This project will determine the links between specific agents in male seminal fluid and the female immune response, and will make progress towards new diagnostic tests and treatment options for unexplained subfertility and gestational disorders.
Immunomodulatory Vaccines In The Treatment Of Peanut Allergy
Funder
National Health and Medical Research Council
Funding Amount
$678,899.00
Summary
Peanut allergy is the most common cause of food-induced anaphylactic reactions in Australia and is a major burden to our healthcare system. Current clinical practice advice dietary avoidance to prevent fatal anaphylactic responses. We propose the use of an immunomodulatory vaccine to re-write the immune response to peanut antigens, from an allergic to a tolerant phenotype. This study will provide novel insights into rational approaches for manipulating immune memory to food allergens.
Mechanisms and management of inducible tolerance to synthetic insecticides and Bacillus thuringiensis (Bt)-formulations in Australian populations of diamondback moth. Insects have a cunning ability to respond to damaging environments by evolving genetic resistance or mobilising metabolic tolerance mechanisms. Recent observations of inducible tolerance to synthetic and biopesticides, which can be transmitted to offspring by a maternal effect has the potential to cause ecological and economic prob ....Mechanisms and management of inducible tolerance to synthetic insecticides and Bacillus thuringiensis (Bt)-formulations in Australian populations of diamondback moth. Insects have a cunning ability to respond to damaging environments by evolving genetic resistance or mobilising metabolic tolerance mechanisms. Recent observations of inducible tolerance to synthetic and biopesticides, which can be transmitted to offspring by a maternal effect has the potential to cause ecological and economic problems in agricultural production. We will use field-collected Diamondback moth (DBM), a major insect pest in canola and brassica vegetable crops, to investigate the genetic implications of inducible tolerance for the integrated management of DBM and for the design of new resistance management strategies.Read moreRead less
Control of foliar diseases in horticulture using milk components: widening applicability through understanding mechanisms. Fungal diseases, such as powdery mildew and botrytis grey mould, have the potential to cause considerable losses in horticultural crops. Chemical fungicides, some of which are broad-spectrum biocides potentially harmful to human health, are applied routinely in disease management. Milk and whey, which can damage powdery mildew fungi, offer alternatives to conventional fungic ....Control of foliar diseases in horticulture using milk components: widening applicability through understanding mechanisms. Fungal diseases, such as powdery mildew and botrytis grey mould, have the potential to cause considerable losses in horticultural crops. Chemical fungicides, some of which are broad-spectrum biocides potentially harmful to human health, are applied routinely in disease management. Milk and whey, which can damage powdery mildew fungi, offer alternatives to conventional fungicides. Identification of the components of milk which damage fungi, and their mechanisms of activity, will facilitate the development of environmentally sustainable strategies for management of fungal diseases in Australian horticulture. This will have particular benefits for personnel who regularly apply fungicides in glasshouses.Read moreRead less
Beneficial arthropods in Coonawarra vineyards and sustainable grape production. Many species of pest and beneficial arthropods live in vines and groundcover of vineyards. Vignerons often devote considerable effort to sustain populations of what they believe to be beneficial arthropods. However, the types of natural enemies and techniques to enhance their effectiveness are poorly known. This project aims to identify and quantify the role of natural enemies in controlling the main pest in Coonawar ....Beneficial arthropods in Coonawarra vineyards and sustainable grape production. Many species of pest and beneficial arthropods live in vines and groundcover of vineyards. Vignerons often devote considerable effort to sustain populations of what they believe to be beneficial arthropods. However, the types of natural enemies and techniques to enhance their effectiveness are poorly known. This project aims to identify and quantify the role of natural enemies in controlling the main pest in Coonawarra vineyards, identify their food and shelter requirements, and improve management practices and other techniques to optimise populations of beneficial species. The significance of this project is that it will enable the promotion of insecticide-free production of winegrapes in the Coonawarra.Read moreRead less