Modified Peanut Allergen Combined With A Novel Dietary Adjuvant As A Cure For Peanut Allergy: A Randomised Controlled Trial
Funder
National Health and Medical Research Council
Funding Amount
$1,130,021.00
Summary
Peanut allergy is common and there is no cure. Current studies of peanut immunotherapy have shown the effects are not generally long lasting with many side effects. We plan to study a novel form of oral peanut immunotherapy using modified peanut and a dietary fibre (modified starch) supplement. We have evidence that modified peanut may work to desensitise patients with less side effects and that the diet supplement protects animals from developing food allergy.
Maternal Carriage Of Prevotella During Pregnancy Influences Offspring Innate Immune Responses And Asthma At Age 7
Funder
National Health and Medical Research Council
Funding Amount
$916,798.00
Summary
This project will investigate the relationship between the bacteria a mother carries in her gut during pregnancy and her baby’s risk of developing allergic disease and asthma. We will investigate underlying immune pathways and conduct experiments in mice to determine whether inoculating mothers with a specific type of bacteria known as Prevotella could be used to prevent food allergies and asthma in the offspring.
Comparing Pneumococcal Vaccines In A High Risk Population: A Randomised Controlled Trial Of Immunogenicity, Safety And Impact On Carriage Of Pneumococcal Conjugate And Polysaccharide Vaccines In Infants In Papua New Guinea
Funder
National Health and Medical Research Council
Funding Amount
$1,042,670.00
Summary
Pneumococcal disease is a major cause of pneumonia and meningitis in infants in developing countries in particular resulting in an estimated 800,000 deaths each year. This project will study how well pneumococcal vaccines perform in 260 high-risk infants in Papua New Guinea. We will examine how well the vaccines stimulate protective immunity and reduce babies carrying the pneumococcal bacteria in their nose and how long this immunity lasts for. The study will inform global immunisation policy.
Epithelial Drivers Of Neutrophil Plasticity In Early Cystic Fibrosis Lung Disease
Funder
National Health and Medical Research Council
Funding Amount
$849,462.00
Summary
Why airway inflammation becomes chronic so early in life for people with cystic fibrosis (CF) is unclear. This project will use the latest techniques to characterise immune cells found in airways of infants with CF and model in the laboratory how immune cells react to the CF airway. We will challenge CF airway cells with different bugs that can infect the lung, then see if the responses by CF airway cells can change the normal response of immune cells, triggering chronic disease.